2600559-12-2
2600559-12-2
Chemical Structure
KIF18A-IN-1
- CAS No.: 2600559-12-2
- Formula:C28H40N4O5S2
- Molecular Weight:576.77
IUPAC Name: 4-(N-(tert-butyl)sulfamoyl)-N-(3-(N-(tert-butyl)sulfamoyl)phenyl)-2-(6-azaspiro[2.5]octan-6-yl)benzamide
InChIKey: XQJSQKALBZNWEV-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(S(=O)(NC(C)(C)C)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(=O)(NC(C)(C)C)=O)=C4
Biological Activity: KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KIF18A-IN-1 | 98.06% | KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells. | ||||||||||||||||||||
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References
- [1]. Pharmaceutical compositions comprising kinesin-like protein KIF18A inhibitors for the treatment of cancer. World Intellectual Property Organization, WO2023212714 A1 2023-11-02.
- [2]. Payton M, et al. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2024 Jan;5(1):66-84. [Content Brief]
Keywords
