KIF18A-IN-1
Based on 1 publication(s) in Google Scholar
KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.06%
- CAS 番号: 2600559-12-2
- 分子式: C28H40N4O5S2
- 分子量:576.77
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 KIF18A-IN-1
MoreKinesin アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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KIF18A |
体外実験
KIF18A-IN-1 (compound C9) has broad inhibitory activity against cancer cell lines, with IC50 values ??of 5.09 nM (MDA-MB-157), 12.4 nM (OVCAR-8), 6.11 nM (HCC-1806), 20.9 nM (HeLa), and 10.3 nM (OVCAR-3) after 5 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR-8
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Concentration:0 nM, 4 nM, 8 nM, 16 nM, 32 nM, 64 nM, 128 nM
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Incubation Time:5 days
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Result:Exhibited the IC50 and IC90 values against OVACR-8 of 11 nM and 33 nM, respectivley.
化学情報
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CAS 番号 2600559-12-2
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性状 Solid
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分子量 576.77
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分子式 C28H40N4O5S2
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C(S(=O)(NC(C)(C)C)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(=O)(NC(C)(C)C)=O)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Jan 2;16(1):307. PMID: 39747049
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (173.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7338 mL | 8.6690 mL | 17.3379 mL | 43.3448 mL |
| 5 mM | 0.3468 mL | 1.7338 mL | 3.4676 mL | 8.6690 mL | |
| 10 mM | 0.1734 mL | 0.8669 mL | 1.7338 mL | 4.3345 mL | |
| 15 mM | 0.1156 mL | 0.5779 mL | 1.1559 mL | 2.8897 mL | |
| 20 mM | 0.0867 mL | 0.4334 mL | 0.8669 mL | 2.1672 mL | |
| 25 mM | 0.0694 mL | 0.3468 mL | 0.6935 mL | 1.7338 mL | |
| 30 mM | 0.0578 mL | 0.2890 mL | 0.5779 mL | 1.4448 mL | |
| 40 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0836 mL | |
| 50 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8669 mL | |
| 60 mM | 0.0289 mL | 0.1445 mL | 0.2890 mL | 0.7224 mL | |
| 80 mM | 0.0217 mL | 0.1084 mL | 0.2167 mL | 0.5418 mL | |
| 100 mM | 0.0173 mL | 0.0867 mL | 0.1734 mL | 0.4334 mL |
KIF18A-IN-1 関連分類
HY-145034 関連分類
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