2. Others GPCR/G Protein Anti-infection Metabolic Enzyme/Protease
  3. Environmental Pollutants Hydroxycarboxylic Acid Receptor (HCAR) Bacterial Endogenous Metabolite
  4. Lactic acid sodium (60% w/w in water)

乳酸ナトリウム  (Synonyms: Lactate sodium; Lactic acid sodium)

製品番号: HY-B2227B 純度: 98.0%
COA 取扱説明書 Technical Support

Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative.
This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 72-17-3

容量 価格（税別） 在庫状況 数量
Solvent
200 μL USD 30 在庫あり
Solvent
1 mL USD 50 在庫あり
Solvent
2 mL USD 80 在庫あり
Solvent
5 mL USD 128 在庫あり
Solvent
10 mL USD 167 在庫あり
50 mL   お問い合わせ  
100 mL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 51 publication(s) in Google Scholar

Other Forms of Lactic acid sodium (60% w/w in water):

乳酸ナトリウム 関連抗体

Top Publications Citing Use of Products

顧客検証

WB
IP
IF
RT-PCR

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 29:e09477.  [Abstract]

    Following the direct addition of lactic acid (a final concentration of 100 mM) to the culture medium for 12 h, western blotting, and immunoprecipitation assays revealed a significant increase in the total lactylation and corresponding lysine-312 lactylation levels in ASH2L

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar 27:e2413709.  [Abstract]

    Western blot of UGDH lactylation in chondrocytes with Lactic acid sodium (lactate) (25 mM) treatment for 24 h.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Apr:81:103553.  [Abstract]

    Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Mar 20;16(1):193.  [Abstract]

    Lactate sodium (5-15 mM; 24 h) ​​results​​ in increased H4K12la (red) levels in CCSCs compared to the control group.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Co-IP detected the effect of lactate on YY1 protein lactylation modification.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Mar 5;43(1):68.  [Abstract]

    Lactate sodium increases IGF-1R levels in PI-resistant KAS-6/1 and U266 cells.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698.  [Abstract]

    Lactate (NALA) (300 mM; 24 h) significantly upregulates α-MHC K1897 lactylation in H9c2 cells.

    Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309.

    The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.

    Hydroxycarboxylic Acid Receptor (HCAR) アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    HCAR1 HCAR2

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

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    製品説明

    Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative[3].
    This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).

    IC50 & Target

    HCAR1

     

    体外実験

    Lactic acid (20 mM; 24, 48 h) sodium (60% w/w in water) results in a significant decrease in cell proliferation and migration, acting and switching cell metabolism toward oxidative phosphorylation[1].
    Lactic acid (20 mM; 24 h) sodium (60% w/w in water) shows an increase in the protein and mRNA expression levels of MCT1 and HCAR1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    乳酸ナトリウム 関連抗体

    Cell Proliferation Assay[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24, 48 h
    Result: Inhibited cell proliferation and migration.

    Western Blot Analysis[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Showed an increase in the protein expression levels of MCT1 and HCAR1

    RT-PCR[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
    体内実験

    Lactic acid (1.6 g/kg; pH 7.4; subcutaneous; daily from Day 8 to 30 days) sodium (60% w/w in water) shows CD8+ T cell-dependent tumor growth inhibition in MC38 colon cancer model[2].
    Note: The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female C57BL/6 mice with MC38 colon cancer cells[2]
    Dosage: 1.6 g/kg
    Administration: Subcutaneous; daily from Day 8 to 30 days
    Result: Significantly suppressed tumor growth.
    分子量

    112.06

    分子式

    C3H5NaO3
    CAS 番号
    Appearance

    Liquid (Density: 1.33 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    [Na].O=C(O)C(O)C
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Solution, -20°C, 2 years
    溶剤 & 溶解度
    体外: 

    H2O : 116.67 mg/mL (1041.14 mM; Need ultrasonic)

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    一般には略語で表示されます：C1V1 = C2V2

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    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.0%

    COA (249 KB) HNMR (231 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 8.9238 mL 44.6190 mL 89.2379 mL 223.0948 mL
    5 mM 1.7848 mL 8.9238 mL 17.8476 mL 44.6190 mL
    10 mM 0.8924 mL 4.4619 mL 8.9238 mL 22.3095 mL
    15 mM 0.5949 mL 2.9746 mL 5.9492 mL 14.8730 mL
    20 mM 0.4462 mL 2.2309 mL 4.4619 mL 11.1547 mL
    25 mM 0.3570 mL 1.7848 mL 3.5695 mL 8.9238 mL
    30 mM 0.2975 mL 1.4873 mL 2.9746 mL 7.4365 mL
    40 mM 0.2231 mL 1.1155 mL 2.2309 mL 5.5774 mL
    50 mM 0.1785 mL 0.8924 mL 1.7848 mL 4.4619 mL
    60 mM 0.1487 mL 0.7436 mL 1.4873 mL 3.7182 mL
    80 mM 0.1115 mL 0.5577 mL 1.1155 mL 2.7887 mL
    100 mM 0.0892 mL 0.4462 mL 0.8924 mL 2.2309 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Lactic acid sodium (60% w/w in water) Related Classifications

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lactic acid sodium (60% w/w in water)72-17-3DL-Lactic acidE-270E270E 270Environmental PollutantsHydroxycarboxylic Acid Receptor (HCAR)BacterialEndogenous MetaboliteEnvironmental Contaminantshydroxycarboxylic acid receptor 1HCAR1epigeneticlysine residues lactylationglycolysisoxidative phosphorylationoncometaboliteanti-tumorInhibitorinhibitorinhibit

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    製品番号:
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