L-Lactic acid sodium
Based on 14 publication(s) in Google Scholar
L-lactate Sodium (Sodium (S)-2-hydroxypropanoate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity.
For research use only. We do not sell to patients.
- Purity: 98.54%
- CAS No.: 867-56-1
- Formula: C3H5NaO3
- Molecular Weight:112.06
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Lactic acid sodium
More- Adv Sci (Weinh). 2024 Dec 31:e2411943. [Abstract]
- Adv Sci (Weinh). 2024 Mar;11(10):e2304761. [Abstract]
- Small. 2022 Apr;18(13):e2107236. [Abstract]
- Diabetologia. 2024 Jul;67(7):1429-1443. [Abstract]
- Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
- Int J Biol Macromol. 2022 Dec 1;222(Pt B):2225-2243. [Abstract]
- Cell Chem Biol. 2026 Feb 19;33(2):213-226.e5. [Abstract]
- J Autoimmun. 2025 Apr 2:153:103411. [Abstract]
- Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
- Commun Chem. 2025 Dec 9. [Abstract]
- J Ethnopharmacol. 2025 Jan 31:340:119287. [Abstract]
- Int Immunopharmacol. 2024 Jan 5:126:111265. [Abstract]
- Exp Eye Res. 2025 Mar 27:110361. [Abstract]
- PLoS One. 2025 Sep 18;20(9):e0332825. [Abstract]
Customer Validation & Images
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RT-PCR
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Bio/Physico-chemical Assay
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WB
All Endogenous Metabolite Isoforms
MoreAll Antibiotic Isoforms
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Biological Activity
L-Lactic Acid (24-48 h) sodium secreted from gastric mucosal cells enhances growth of Helicobacter pylori[1].
L-Lactic Acid (48 h) sodium shows antiproliferative activity against human A549 and MRC5 cells, with IC50 of 26.6 μM and 23.93 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 867-56-1
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Appearance Solid
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Molecular Weight 112.06
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Formula C3H5NaO3
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Color White to off-white
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SMILES
[C@@H](C(O)=O)(C)O.[Na]
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Synonyms
(S)-2-Hydroxypropanoic acid sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (14)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury. [Abstract]2024 Dec 31:e2411943. PMID: 39737891 -
Adv Sci (Weinh)
Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration. [Abstract]2024 Mar;11(10):e2304761. PMID: 38145353
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Mar;11(10):e2304761. [Abstract]
Evaluation of the viability of BMSCs cultured on microspheres with or without lactate (L-Lactic acid; 6 mM) for 24 h. Fluorescence images of the live/dead assays of BMSCs cultured on microspheres with or without lactate for 24 h.
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Small
Stemness Maintenance and Massproduction of Neural Stem Cells on Poly L-Lactic Acid Nanofibrous Membrane Based on Piezoelectriceffect. [Abstract]2022 Apr;18(13):e2107236. PMID: 35166031 -
Diabetologia
2024 Jul;67(7):1429-1443. PMID: 38676722 -
Int J Biol Macromol
Lactate-related genes signature as a novel prognostic landscape in laryngeal squamous cell carcinoma: insights from 156 machine learning algorithms and in vitro validation. [Abstract]2025 Aug 24;323(Pt 1):147098. PMID: 40858160
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
Lactate (L-Lactic acid; 24 h) TU668 cells, the expression levels of hub genes were quantified by PCR.
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
Lactate (L-Lactic acid; 15 mM; 24, 48, 72 h) cell viability was assessed using the CCK-8 assay in TU686 cells.
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
Lactate (L-Lactic acid; 15 mM; 0, 48 h), cell migration capacity was evaluated via a scratch wound healing assay in TU686 cells.
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Int J Biol Macromol
HIF1α lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer. [Abstract]2022 Dec 1;222(Pt B):2225-2243. PMID: 36209908
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2022 Dec 1;222(Pt B):2225-2243. [Abstract]
Assessed by WB, extracellular lactate (L-Lactic acid) treatment (10 mM, 72 h) significantly increased VE-cadherin and p-EphA2 (Ser897) expressions, which could be reversed by MCT1 silencing PC-3 cells.
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Cell Chem Biol
2026 Feb 19;33(2):213-226.e5. PMID: 41643668 -
J Autoimmun
Neutrophil extracellular traps induce trophoblasts pyroptosis via enhancing NLRP3 lactylation in SLE pregnancies. [Abstract]2025 Apr 2:153:103411. PMID: 40179478 -
Cell Rep
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy. [Abstract]2025 Apr 9;44(4):115545. PMID: 40215164
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
HT1376 and RT112 cells were treated with lactate (10 mM)/oxamate (10 mM) for 24 h. Then, the cells were harvested for lactic acid content detection analysis.
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
HT1376 and RT112 cells were treated with lactate (10 mM)/oxamate (10 mM) for 24 h. Then, the cells were harvested for lactic acid content detection analysis.
L-Lactic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545. [Abstract]
HT1376 and RT112 cells were treated with the lactate (10 mM) for 48 h then treated with continuous doses of EV for 24 h and harvested for CCK-8 assays to measure the IC50 values of EV.
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Commun Chem
Stepped collisional energy improves protein acylation identification by eliminating positional bias of cyclic immonium ions. [Abstract]2025 Dec 9. PMID: 41366033 -
J Ethnopharmacol
Icariin maintaining TMEM119-positive microglial population improves hippocampus-associated memory in senescent mice in relation to R-3-hydroxybutyric acid metabolism. [Abstract]2025 Jan 31:340:119287. PMID: 39736348 -
Int Immunopharmacol
Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers. [Abstract]2024 Jan 5:126:111265. PMID: 38000233 -
Exp Eye Res
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate. [Abstract]2025 Mar 27:110361. PMID: 40157629 -
PLoS One
2025 Sep 18;20(9):e0332825. PMID: 40966256
Solvent & Solubility
H2O : ≥ 100 mg/mL (892.38 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Takahashi T, et al. L-lactic acid secreted from gastric mucosal cells enhances growth of Helicobacter pylori. Helicobacter. 2007 Oct;12(5):532-40. [Content Brief]
[2]. Recio R, et al. Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29;138:644-660. [Content Brief]
[3]. Zhang G, et al. L-lactic acid's improvement of swimming endurance in mice. Int J Sport Nutr Exerc Metab. 2009 Dec;19(6):673-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.9238 mL | 44.6190 mL | 89.2379 mL | 223.0948 mL |
| 5 mM | 1.7848 mL | 8.9238 mL | 17.8476 mL | 44.6190 mL | |
| 10 mM | 0.8924 mL | 4.4619 mL | 8.9238 mL | 22.3095 mL | |
| 15 mM | 0.5949 mL | 2.9746 mL | 5.9492 mL | 14.8730 mL | |
| 20 mM | 0.4462 mL | 2.2309 mL | 4.4619 mL | 11.1547 mL | |
| 25 mM | 0.3570 mL | 1.7848 mL | 3.5695 mL | 8.9238 mL | |
| 30 mM | 0.2975 mL | 1.4873 mL | 2.9746 mL | 7.4365 mL | |
| 40 mM | 0.2231 mL | 1.1155 mL | 2.2309 mL | 5.5774 mL | |
| 50 mM | 0.1785 mL | 0.8924 mL | 1.7848 mL | 4.4619 mL | |
| 60 mM | 0.1487 mL | 0.7436 mL | 1.4873 mL | 3.7182 mL | |
| 80 mM | 0.1115 mL | 0.5577 mL | 1.1155 mL | 2.7887 mL | |
| 100 mM | 0.0892 mL | 0.4462 mL | 0.8924 mL | 2.2309 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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