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  4. L-Lactic acid

L-Lactic acid  (Synonyms: (S)-2-Hydroxypropanoic acid)

Cat. No.: HY-Y0479 Purity: 99.57%
COA
SDS
Handling Instructions Technical Support

L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity.

For research use only. We do not sell to patients.

CAS No. : 79-33-4

Size Price Stock Quantity
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid or liquid
500 mg In-stock
1 g In-stock
5 g In-stock
10 g In-stock
50 g   Get quote  

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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of L-Lactic acid:

L-Lactic acid Related Antibodies

Top Publications Citing Use of Products

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098.  [Abstract]

    Lactate (L-Lactic acid; 24 h) TU668 cells, the expression levels of hub genes were quantified by PCR.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098.  [Abstract]

    Lactate (L-Lactic acid; 15 mM; 24, 48, 72 h) cell viability was assessed using the CCK-8 assay in TU686 cells.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098.  [Abstract]

    Lactate (L-Lactic acid; 15 mM; 0, 48 h), cell migration capacity was evaluated via a scratch wound healing assay in TU686 cells.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    HT1376 and RT112 cells were treated with lactate (10 mM)/oxamate (10 mM) for 24 h. Then, the cells were harvested for lactic acid content detection analysis.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    HT1376 and RT112 cells were treated with lactate (10 mM)/oxamate (10 mM) for 24 h. Then, the cells were harvested for lactic acid content detection analysis.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    HT1376 and RT112 cells were treated with the lactate (10 mM) for 48 h then treated with continuous doses of EV for 24 h and harvested for CCK-8 assays to measure the IC50 values of EV.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Mar;11(10):e2304761.  [Abstract]

    Evaluation of the viability of BMSCs cultured on microspheres with or without lactate (L-Lactic acid; 6 mM) for 24 h. Fluorescence images of the live/dead assays of BMSCs cultured on microspheres with or without lactate for 24 h.

    L-Lactic acid purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2022 Dec 1;222(Pt B):2225-2243.  [Abstract]

    Assessed by WB, extracellular lactate (L-Lactic acid) treatment (10 mM, 72 h) significantly increased VE-cadherin and p-EphA2 (Ser897) expressions, which could be reversed by MCT1 silencing PC-3 cells.

    View All Antibiotic Isoform Specific Products:

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity[1][2][3].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    L-Lactic Acid (24-48 h) secreted from gastric mucosal cells enhances growth of Helicobacter pylori[1].
    L-Lactic Acid (48 h) shows antiproliferative activity against human A549 and MRC5 cells, with IC50 of 26.6 μM and 23.93 μM[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Lactic acid Related Antibodies
    In Vivo

    L-Lactic acid (25-50 mg/kg, i.p., twice, 4 days apart) dose-dependently enhances swimming endurance in mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    90.08

    Formula

    C3H6O3
    CAS No.
    Appearance

    <53°C Solid,>53°C Liquid

    Color

    Colorless to off-white

    SMILES

    C[C@H](O)C(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (1110.12 mM; Need ultrasonic)

    DMSO : 100 mg/mL (1110.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 11.1012 mL 55.5062 mL 111.0124 mL
    5 mM 2.2202 mL 11.1012 mL 22.2025 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (23.09 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (23.09 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.57%

    SDS (476 KB)

    COA (250 KB) HNMR (212 KB) RP-HPLC (273 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 11.1012 mL 55.5062 mL 111.0124 mL 277.5311 mL
    5 mM 2.2202 mL 11.1012 mL 22.2025 mL 55.5062 mL
    10 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
    15 mM 0.7401 mL 3.7004 mL 7.4008 mL 18.5021 mL
    20 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
    25 mM 0.4440 mL 2.2202 mL 4.4405 mL 11.1012 mL
    30 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
    40 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
    50 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
    60 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
    80 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
    100 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Lactic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Lactic acid79-33-4(S)-2-Hydroxypropanoic acidEnvironmental PollutantsBacterialAntibioticEndogenous MetaboliteEnvironmental ContaminantsPoly-lactic acidAntiproliferative.Inhibitorinhibitorinhibit

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