Peptides

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Peptides, which are short chains of amino acids linked by peptide bonds, have a variety of biological functions, such as, anti-thrombosis, anti-hypertension, anti-microbial, anti-tumor and anti-oxidation, immune-regulation, and cholesterol-lowering effects. Peptides have been widely used in functional analysis, antibody research, vaccine research, and especially the field of drug research and development.

MedChemExpress (MCE) offers a comprehensive collection of high quality peptides including peptide inhibitors, β-amyloids, therapeutic peptides and amino acid derivatives to clients in pharmaceutical and academic institutions all over the world. Unlimited Custom Peptide Service is also available to help researchers propel their projects.

Peptides

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Peptides (9394):

By Type:	Peptide-Macromolecule Conjugates (1) Fluorescent Peptides (26) Antimicrobial Peptides (291) Tag Peptides (21) Therapeutic Peptides (264) Cosmetic Peptides (102) Cell-penetrating Peptides (169) Cyclic Peptides (361) Peptide Toxins (151) Amino acids and Derivatives (1681)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-75564

Cyclo(Ala-Gly)	4526-77-6
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM.

HY-P0060

Tetracosactide	16960-16-0	99.46%
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.

HY-P0132

YIGSR	110590-64-2	99.38%
YIGSR (Laminin Fragment 929-933) is a polypeptide that inhibits tumor growth and metastasis of leukemia cells. YIGSR specifically binds to the 67kDa laminin receptor and regulates the expression of eNOS in endothelial cells. YIGSR can be used in leukemia-related research.

HY-P1022

Kisspeptin-54(human)	374683-24-6	99.39%
Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with K_i values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone.

HY-P1029

MLCK inhibitor peptide 18	224579-74-2	98.04%
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC₅₀ of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.

HY-P1192

GR-73632	133156-06-6	99.89%
GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus.

HY-P1280

Margatoxin	145808-47-5	99.17%
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

HY-P1845

PACAP-38 (31-38), human, mouse, rat	138764-85-9	98.80%
PACAP-38 (31-38), human, mouse, rat is a fragment containing the C-terminal 31-38 fragment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (31-38), human, mouse, rat does not bind to the PACAP receptor.

HY-P1997

Ferrichrome Iron-free	34787-28-5	≥98.0%
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

HY-P2210

BigLEN(mouse)	501036-69-7	99.98%
BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a K_d of ∼0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism.

HY-P2237

Boc-Leu-Gly-Arg-AMC	65147-09-3	98.66%
Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays.

HY-P2287

Cortagine		98.68%
Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an EC₅₀ of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive agent in the mouse model.

HY-P2544

[Lys8, Lys9]-Neurotensin (8-13)	139026-64-5	99.95%
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with K_i values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively.

HY-P3579

Gastric Inhibitory Peptide, porcine	11063-17-5	99.12%
Gastric Inhibitory Peptide (GIP (1-42)), porcine is a porcine glucose-dependent insulinotropic polypeptide and inhibitor of pentagastrin-stimulated gastric acid secretion. Gastric Inhibitory Peptide, porcine stimulates endogenous somatostatin release. Gastric Inhibitory Peptide, porcine acts in a dose- and time-dependent manner in conscious, chronic gastric fistula-equipped rats.

HY-P3732

RGD-4C	332179-76-7	99.91%
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models.

HY-P4073

ANG1005	1075214-55-9	98.83%
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system.

HY-P5411

OVA-T4 Peptide	148274-88-8	99.59%
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a low-affinity variant of OVA (257-264) (SIINFEKL). OVA-T4 Peptide has similar binding to H-2Kb MHC class I molecules as OVA (257-264), but has a much lower affinity for the OT-I TCR25.

HY-P5506

C5a Receptor agonist, W5Cha	144555-23-7	99.13%
C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement C5a receptor (C5aR) agonist (EC₅₀=0.2 μM), a hexapeptide derived from the C-terminus of C5a with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the C5a receptor through its C-terminal arginine, thereby activating the receptor.

HY-P5762

Phoenixin-14	1415039-79-0	99.28%
Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia.

HY-136727

Ac-LEVD-CHO	402832-01-3	98.41%
Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al.

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