1. GPCR/G Protein
  2. CRFR
  3. Cortagine

Cortagine 

Cat. No.: HY-P2287
Handling Instructions

Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cortagine Chemical Structure

Cortagine Chemical Structure

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Description

Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model[1].

IC50 & Target

IC50: 2.6 nM (rCRF1)[1]

In Vitro

Cortagine inhibits rCRF1 (EC50=0.18 nM) and mCRF (EC50=16 nM) in transfected HEK-293 cells[1].

In Vivo

Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice[1].

Molecular Weight

4442.06

Formula

C₁₉₂H₃₂₃N₅₅O₆₃S

Sequence

{Glp}-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Glu-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ala-NH2

Sequence Shortening

{Glp}GPPISIDLSLELLREVLEMERAEQLAQQAANNRLLLDTA-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CortagineCRFRCorticotropin-releasing Factor Receptorcorticotropin-releasingfactorreceptorsubtype1CRF1anxiogenicantidepressiveInhibitorinhibitorinhibit

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Cortagine
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HY-P2287
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