N-Butanoyl-L-homoserine lactone (Synonyms: C4-HSL; N-Butyryl-L-homoserine lactone)

Name: N-Butanoyl-L-homoserine lactone
Brand: MedChemExpress
SKU: HY-114816
Rating: 5.0 (3 reviews)

Cat. No.: HY-114816 Purity: 98.77%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.

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N-Butanoyl-L-homoserine lactone 화학구조

CAS No. : 67605-85-0

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	견적 받기
50 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of N-Butanoyl-L-homoserine lactone:

N-Butanoyl-DL-homoserine lactone In-stock
N-Butanoyl-L-homoserine lactone (Standard) In-stock
N-butyryl-L-Homoserine lactone-d₅ 견적 받기

3 Publications Citing Use of MCE N-Butanoyl-L-homoserine lactone

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View All Isoforms

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm^[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa^[2]^[3].

IC₅₀ & Target^[1]

Cleavable Linker

In Vitro

The dissociation constant (K_d value) of aptamer binding to N-Butanoyl-L-homoserine lactone (C4-HSL) is 28.47 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

171.20

화학식

C₈H₁₃NO₃

CAS No.

67605-85-0

Appearance

Solid

Color

White to off-white

SMILES

CCCC(N[C@H]1CCOC1=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (584.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 20 mg/mL (116.83 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8413 mL	29.2063 mL	58.4126 mL
5 mM	1.1683 mL	5.8413 mL	11.6825 mL
10 mM	0.5841 mL	2.9206 mL	5.8413 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.77%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (249 KB) HNMR (258 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1

[2]. Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041. [Content Brief]

[3]. Feng Sun, et al. Advance of the diversity of bacterial quorum sensing and quorum quenching. National Natural Science Foundation of China. Published online 9 October 2018.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.8413 mL	29.2063 mL	58.4126 mL	146.0315 mL
	5 mM	1.1683 mL	5.8413 mL	11.6825 mL	29.2063 mL
	10 mM	0.5841 mL	2.9206 mL	5.8413 mL	14.6031 mL
	15 mM	0.3894 mL	1.9471 mL	3.8942 mL	9.7354 mL
	20 mM	0.2921 mL	1.4603 mL	2.9206 mL	7.3016 mL
	25 mM	0.2337 mL	1.1683 mL	2.3365 mL	5.8413 mL
	30 mM	0.1947 mL	0.9735 mL	1.9471 mL	4.8677 mL
	40 mM	0.1460 mL	0.7302 mL	1.4603 mL	3.6508 mL
	50 mM	0.1168 mL	0.5841 mL	1.1683 mL	2.9206 mL
	60 mM	0.0974 mL	0.4868 mL	0.9735 mL	2.4339 mL
	80 mM	0.0730 mL	0.3651 mL	0.7302 mL	1.8254 mL
	100 mM	0.0584 mL	0.2921 mL	0.5841 mL	1.4603 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

N-Butanoyl-L-homoserine lactone Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Butanoyl-L-homoserine lactone67605-85-0C4-HSL N-Butyryl-L-homoserine lactoneADC LinkerBacterialAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesantibacterialbiofilmInhibitorinhibitorinhibit

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N-Butanoyl-L-homoserine lactone (Synonyms: C4-HSL; N-Butyryl-L-homoserine lactone)

고객리뷰

Other Forms of N-Butanoyl-L-homoserine lactone:

N-Butanoyl-L-homoserine lactone Related Antibodies

3 Publications Citing Use of MCE N-Butanoyl-L-homoserine lactone

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

N-Butanoyl-L-homoserine lactone Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

N-Butanoyl-L-homoserine lactone Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report