NADH 

NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.

NADH (200 μM) reverses mitochondrial dysfunction and cell apoptosis in AIFM1 mutant稳转细胞系^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

665.44

C₂₁H₂₉N₇O₁₄P₂

58-68-4

O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H](N3C=C(CC=C3)C(N)=O)[C@@H]([C@@H]2O)O)(O)=O)(O)=O)N4C5=NC=NC(N)=C5N=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ying W. NAD+ and NADH in cellular functions and cell death. Front Biosci. 2006 Sep 1;11:3129-48.
   [Content Brief]

  [2]. Chen Z, et al. Therapeutic potential of NADH: in neurodegenerative diseases characterizde by mitochondrial dysfunction. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Jan;38(1):57-62.
   [Content Brief]

  [3]. Yan LJ, et al. NADH/NAD⁺ Redox Imbalance and Diabetic Kidney Disease. Biomolecules. 2021;11(5):730. Published 2021 May 14.  [Content Brief]