2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Naronapride

Naronapride (ATI-7505) is a potent prokinetic 5-HT4 receptor agonist. Naronapride can be used for gastrointestinal diseases research.

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Naronapride

Naronapride Estructura química

No. CAS : 860174-12-5

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 3 - 5 weeks
5 mg Obtener un presupuesto 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 3 - 5 weeks
10 mg Obtener un presupuesto 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 3 - 5 weeks
25 mg Obtener un presupuesto 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 3 - 5 weeks
50 mg Obtener un presupuesto 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 3 - 5 weeks
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  
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Naronapride Related Antibodies

Top Publications Citing Use of Products

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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Descripciòn

Naronapride (ATI-7505) is a potent prokinetic 5-HT4 receptor agonist. Naronapride can be used for gastrointestinal diseases research[1].

IC50 & Target[1]

5-HT4 Receptor

 

Ensayo clínico
Peso molecular

537.09

Fòrmula

C27H41ClN4O5
No. CAS
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CCCCCN1C[C@@H]([C@@H](CC1)NC(C2=CC(Cl)=C(C=C2OC)N)=O)OC)O[C@H]3CN4CCC3CC4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (186.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8619 mL 9.3094 mL 18.6189 mL
5 mM 0.3724 mL 1.8619 mL 3.7238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (4.65 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (4.65 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8619 mL 9.3094 mL 18.6189 mL 46.5471 mL
5 mM 0.3724 mL 1.8619 mL 3.7238 mL 9.3094 mL
10 mM 0.1862 mL 0.9309 mL 1.8619 mL 4.6547 mL
15 mM 0.1241 mL 0.6206 mL 1.2413 mL 3.1031 mL
20 mM 0.0931 mL 0.4655 mL 0.9309 mL 2.3274 mL
25 mM 0.0745 mL 0.3724 mL 0.7448 mL 1.8619 mL
30 mM 0.0621 mL 0.3103 mL 0.6206 mL 1.5516 mL
40 mM 0.0465 mL 0.2327 mL 0.4655 mL 1.1637 mL
50 mM 0.0372 mL 0.1862 mL 0.3724 mL 0.9309 mL
60 mM 0.0310 mL 0.1552 mL 0.3103 mL 0.7758 mL
80 mM 0.0233 mL 0.1164 mL 0.2327 mL 0.5818 mL
100 mM 0.0186 mL 0.0931 mL 0.1862 mL 0.4655 mL
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Naronapride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naronapride860174-12-5ATI-7505ATI7505ATI 75055-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorchronic constipationprokineticgastrointestinal diseaseInhibitorinhibitorinhibit

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Nombre del producto:
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Cat. No.:
HY-121826
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