Nebivolol
Based on 6 publication(s) in Google Scholar
Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 118457-14-0
- Formula: C22H25F2NO4
- Molecular Weight:405.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Nebivolol
More- Nat Commun. 2024 Sep 16;15(1):8130. [Abstract]
- Free Radic Biol Med. 2026 Aug 16:252:493-508. [Abstract]
- Br J Pharmacol. 2026 Jul;183(13):3780-3795. [Abstract]
- PLoS Genet. 2026 Apr 24;22(4):e1012120. [Abstract]
- J Pharm Biomed Anal. 2021 Feb 20:195:113870. [Abstract]
- Virology. 2023 Aug:585:205-214. [Abstract]
All Adrenergic Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.9 μM
Compound: 16
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Inhibition of mitochondrial respiration in human HCT-116 cells assessed as oxygen consumption rate incubated for 1 hr by Seahorse XF24 extracellular flux analyzer
Inhibition of mitochondrial respiration in human HCT-116 cells assessed as oxygen consumption rate incubated for 1 hr by Seahorse XF24 extracellular flux analyzer
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[PMID: 36893622] |
| MDA-MB-231 | IC50 |
2.1 μM
Compound: 16
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Inhibition of mitochondrial respiration in human MDA-MB-231 cells assessed as oxygen consumption rate incubated for 1 hr by Seahorse XF24 extracellular flux analyzer
Inhibition of mitochondrial respiration in human MDA-MB-231 cells assessed as oxygen consumption rate incubated for 1 hr by Seahorse XF24 extracellular flux analyzer
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[PMID: 36893622] |
Nebivolol improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties[1].
Nebivolol (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM[2].
Nebivolol (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis[2].
Nebivolol (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs[2]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:haCSMCs (human coronary smooth muscle cells) and haECs (endothelial cells)
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Concentration:0.1 μM-10 μM
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Incubation Time:1, 2, 4, 7 or 14 days
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Result:Reduced proliferation in HaECs and HaCSMCs in a concentration- and time-dependent.
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Cell Line:haCSMCs and haECs
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Concentration:0.1 μM-10 μM
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Incubation Time:24 h
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Result:Induced a moderate apoptosis in concentration-dependent and showed a decrease of haCSMCs in the S-phase by 66%.
Chemical Information
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CAS No. 118457-14-0
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Appearance Solid
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Molecular Weight 405.44
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Formula C22H25F2NO4
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Color White to off-white
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SMILES
FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1
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Synonyms
R 065824
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR. [Abstract]2024 Sep 16;15(1):8130. PMID: 39285201 -
Free Radic Biol Med
Targeted delivery of nebivolol via lactoferrin-modified liposomes inhibits NEK7-mediated pyroptosis to ameliorate inflammatory bowel disease. [Abstract]2026 Aug 16:252:493-508. PMID: 42061481 -
Br J Pharmacol
Therapeutic potential of small molecules that block receptor-induced Kv7/M-current suppression in neuroprotection, seizures, and pain. [Abstract]2026 Jul;183(13):3780-3795. PMID: 41956525 -
PLoS Genet
Nebivolol suppresses glioblastoma progression via dual modulation of mitochondrial metabolism and AKT/mTOR/4EBP1 signaling axis. [Abstract]2026 Apr 24;22(4):e1012120. PMID: 42030279 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569 -
Virology
Structure-based virtual screening of ROCK1 inhibitors for the discovery of Enterovirus-A71 antivirals. [Abstract]2023 Aug:585:205-214. PMID: 37384967
Solvent & Solubility
DMSO : 50 mg/mL (123.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13;54(16):1491-9. [Content Brief]
[2]. Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49(2):430-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4665 mL | 12.3323 mL | 24.6646 mL | 61.6614 mL |
| 5 mM | 0.4933 mL | 2.4665 mL | 4.9329 mL | 12.3323 mL | |
| 10 mM | 0.2466 mL | 1.2332 mL | 2.4665 mL | 6.1661 mL | |
| 15 mM | 0.1644 mL | 0.8222 mL | 1.6443 mL | 4.1108 mL | |
| 20 mM | 0.1233 mL | 0.6166 mL | 1.2332 mL | 3.0831 mL | |
| 25 mM | 0.0987 mL | 0.4933 mL | 0.9866 mL | 2.4665 mL | |
| 30 mM | 0.0822 mL | 0.4111 mL | 0.8222 mL | 2.0554 mL | |
| 40 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5415 mL | |
| 50 mM | 0.0493 mL | 0.2466 mL | 0.4933 mL | 1.2332 mL | |
| 60 mM | 0.0411 mL | 0.2055 mL | 0.4111 mL | 1.0277 mL | |
| 80 mM | 0.0308 mL | 0.1542 mL | 0.3083 mL | 0.7708 mL | |
| 100 mM | 0.0247 mL | 0.1233 mL | 0.2466 mL | 0.6166 mL |
Nebivolol Related Classifications
HY-B0203 Related Classifications
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