2. Epigenetics Apoptosis
  3. Histone Acetyltransferase Apoptosis
  4. NU9056

NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells.

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No. CAS : 1450644-28-6

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10 mM * 1 mL in DMSO
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Revisión del cliente

Based on 6 publication(s) in Google Scholar

NU9056 Related Antibodies

Top Publications Citing Use of Products

    NU9056 purchased from MedChemExpress. Usage Cited in: Fish Shellfish Immunol. 2025 Oct 16:168:110946.  [Abstract]

    The healthy grass carp were separately intraperitoneally injected with 21 μl of NU9056 at a concentration of 20 mM or the same amount of DMSO. After 4 days, the tissues of intestines, liver, spleen, and kidney were separately extracted. The mRNA levels of bax, bcl2, and caspase3 were assessed by qRT-PCR.

    NU9056 purchased from MedChemExpress. Usage Cited in: Fish Shellfish Immunol. 2025 Oct 16:168:110946.  [Abstract]

    The healthy grass carp were separately intraperitoneally injected with 21 μl of NU9056 at a concentration of 20 mM or the same amount of DMSO. After 4 days, the tissues of intestines, liver, spleen, and kidney were separately extracted. Caspase3 protein levels were analyzed by Western-blot.

    NU9056 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 9:e2406333.  [Abstract]

    H1299 cells were treated with lactate, A‐485, KAT8‐IN‐1, NU9056 (2 µM), Butyrolactone 3 (MB‐3), or Gln‐AMS for 14 h. Quantitative analysis of extracellular FFAs was conducted post‐treatment.

    NU9056 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Jun 14:597:217005.  [Abstract]

    Treatment with the Tip60 inhibitor NU9056 (20 μM for 18 h) reduced USP26 acetylation. Input and anti-HA immunoprecipitates from HEK293T cells transfected with or without Flag-Tip60 were analyzed by WB.

    NU9056 purchased from MedChemExpress. Usage Cited in: Sens Actuators B Chem. 2024 Aug 1, 412, 135827.

    The effects of adding NU9056 (0-500 μM) to the Tip60 reaction system were analyzed for fluorescence readout and for UV–vis absorbance readout.

    NU9056 purchased from MedChemExpress. Usage Cited in: Sens Actuators B Chem. 2024 Aug 1, 412, 135827.

    Kinetic plots displaying the corresponding relative activity based on fluorescence readout and UV–vis absorbance readout are presented, plotted against the logarithm of NU9056 (0-50 μM) concentrations.

    NU9056 purchased from MedChemExpress. Usage Cited in: Nature. 2023 Oct;622(7981):173-179.  [Abstract]

    Representative western blots of two biological replicates of HEK293T histones treated with A-485 and NU9056 (10 μM for 24 hours).

    Ver todos los productos específicos de isoformas Histone Acetyltransferase:

    Ver todas las isoformas
    CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

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    Descripciòn

    NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1].

    In Vitro

    NU9056 (17-36 μM; 24-96 hours) results in both caspase 3 and caspase 9 activation in a time- and concentration-dependent manner[1].
    ? NU9056 (2.5-40 μM; 2 hours) treatment results in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation[1].
    ? NU9056 treatment also decreases androgen receptor, prostate specific antigen, p53 and p21 protein levels[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    NU9056 Related Antibodies

    Apoptosis Analysis[1]

    Cell Line: LNCaP cells
    Concentration: 17 µM, 24 µM, 36 µM
    Incubation Time: 24 hours, 48 hours, 72 hours, 96 hours
    Result: Induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner.

    Western Blot Analysis[1]

    Cell Line: LNCaP cells
    Concentration: 2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM
    Incubation Time: 2 hours
    Result: Resulted in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation.
    In Vivo

    The mice are injected with Nu9056 (2 μg/g) and the hippocampus is collected 1 h later. Tip60 inhibition reduces H2A.Z binding at the -1 nucleosome of Arc, and the +1 nucleosome of Arc and Syp. Additionally, Nu9056 increases acetylation at the -1 nucleosome of Fos, Tacstd2, and Gria4, and the +1 nucleosome of Gria4[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Peso molecular

    232.37

    Fòrmula

    C6H4N2S4
    No. CAS
    Appearance

    Liquid (Density: 1.60±0.1 g/cm3)

    Color

    Yellow to brown

    SMILES

    C1(SSC2=CC=NS2)=CC=NS1
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Pure form -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvente y solubilidad
    In Vitro: 

    DMSO : ≥ 125 mg/mL (537.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3035 mL 21.5174 mL 43.0348 mL
    5 mM 0.8607 mL 4.3035 mL 8.6070 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Pureza y Documentación

    Purity: 98.81%

    SDS (252 KB)

    COA (250 KB) HNMR (231 KB) LCMS (271 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.3035 mL 21.5174 mL 43.0348 mL 107.5870 mL
    5 mM 0.8607 mL 4.3035 mL 8.6070 mL 21.5174 mL
    10 mM 0.4303 mL 2.1517 mL 4.3035 mL 10.7587 mL
    15 mM 0.2869 mL 1.4345 mL 2.8690 mL 7.1725 mL
    20 mM 0.2152 mL 1.0759 mL 2.1517 mL 5.3794 mL
    25 mM 0.1721 mL 0.8607 mL 1.7214 mL 4.3035 mL
    30 mM 0.1434 mL 0.7172 mL 1.4345 mL 3.5862 mL
    40 mM 0.1076 mL 0.5379 mL 1.0759 mL 2.6897 mL
    50 mM 0.0861 mL 0.4303 mL 0.8607 mL 2.1517 mL
    60 mM 0.0717 mL 0.3586 mL 0.7172 mL 1.7931 mL
    80 mM 0.0538 mL 0.2690 mL 0.5379 mL 1.3448 mL
    100 mM 0.0430 mL 0.2152 mL 0.4303 mL 1.0759 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NU90561450644-28-6NU 9056NU-9056Histone AcetyltransferaseApoptosisHATsHATTip60KAT5apoptosisprostatecanceracetylationInhibitorinhibitorinhibit

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