1450644-28-6
1450644-28-6
Chemical Structure
NU9056
- CAS No.: 1450644-28-6
- Formula:C6H4N2S4
- Molecular Weight:232.37
IUPAC Name: 1,2-di(isothiazol-5-yl)disulfane
InChIKey: MLRAMCAHIWHWRM-UHFFFAOYSA-N
SMILES: C1(SSC2=CC=NS2)=CC=NS1
Biological Activity: NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1].
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NU9056 | 96.62% | NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells. | ||||||||||||||||||||
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References
- [1]. Kelly Coffey, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012;7(10):e45539. [Content Brief]
- [2]. Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018. [Content Brief]
Keywords
