2. Others Metabolic Enzyme/Protease MAPK/ERK Pathway Stem Cell/Wnt
  3. Fluorescent Dye Tyrosinase p38 MAPK ERK
  4. Orcinol

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases.

Para uso exclusivo en investigación. No vendemos a pacientes.

Orcinol

Orcinol Estructura química

No. CAS : 504-15-4

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
500 mg En stock
1 g En stock
5 g En stock
10 g En stock
25 g En stock
50 g En stock
100 g En stock
500 g En stock
> 100 g   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Orcinol Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas p38 MAPK:

Ver todas las isoformas
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

Ver todos los productos específicos de isoformas ERK:

Ver todas las isoformas
ERK ERK1 ERK2 ERK5 ERK8

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases[1][2][3].

IC50 & Target

COX-2

 

In Vitro

Orcinol (0.08-3 mM, 24 hours) exhibites low radical scavenging activity and cytotoxicity[1].
Orcinol (0.5-1 mM, 72 hours treatment) inhibites melanogenesis in B16F10 cells[2].
Orcinol (0.5-1 mM, 24 hours) inhibites the expression of melanogenesis-related genes by upregulating the MAPK/ERK signaling pathway and inhibiting the expression of melanogenesis-related genes such as MITF[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Orcinol Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW264.7 mouse macrophage-like cells
Concentration: 0.08-3 mM
Incubation Time: 24 hours
Result: Exhibited weak radical scavenging activity and relatively low cytotoxicity, with an LC50 of 3 mM and weak DPPH radical scavenging activity.

Cell Viability Assay[2]

Cell Line: B16F10 mouse melanoma cells
Concentration: 0.5-1 mM
Incubation Time: 72 hours
Result: Significantly reduced intracellular tyrosinase activity and melanin content.

RT-PCR[2]

Cell Line: B16F10 mouse melanoma cells
Concentration: 0.5-1 mM
Incubation Time: 24 hours
Result: Significantly downregulated the mRNA levels of MITF, TYR, TRP1, and DCT.
In Vivo

Orcinol (2% included in diet, dietary intake, 9 days) causes a reduction in food intake, urine acidification, and altered nitrogen metabolism in common brushtail possums[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Common brushtail possum (Trichosurus vulpecula)[3]
Dosage: 2%, included in diet
Administration: Dietary intake (2% Orcinol included in diet), 9 days
Result: Caused an immediate reduction in food intake, which returned to normal after 2 days. Urine pH dropped from 7.8 to 5.1, with increased excretion of ammonium nitrogen. No signs of protein catabolism were observed.
Peso molecular

124.14

Fòrmula

C7H8O2
No. CAS
Appearance

Solid

Color

White to yellow

Emission (Em)

695
Excitation (Ex)

670
SMILES

OC1=CC(C)=CC(O)=C1
Structure Classification
Initial Source

Aspergillus niger
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (805.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.0555 mL 40.2774 mL 80.5549 mL
5 mM 1.6111 mL 8.0555 mL 16.1110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.97%

SDS (394 KB)

COA (249 KB) HNMR (241 KB) RP-HPLC (247 KB) LCMS (88 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.0555 mL 40.2774 mL 80.5549 mL 201.3872 mL
5 mM 1.6111 mL 8.0555 mL 16.1110 mL 40.2774 mL
10 mM 0.8055 mL 4.0277 mL 8.0555 mL 20.1387 mL
15 mM 0.5370 mL 2.6852 mL 5.3703 mL 13.4258 mL
20 mM 0.4028 mL 2.0139 mL 4.0277 mL 10.0694 mL
25 mM 0.3222 mL 1.6111 mL 3.2222 mL 8.0555 mL
30 mM 0.2685 mL 1.3426 mL 2.6852 mL 6.7129 mL
40 mM 0.2014 mL 1.0069 mL 2.0139 mL 5.0347 mL
50 mM 0.1611 mL 0.8055 mL 1.6111 mL 4.0277 mL
60 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3565 mL
80 mM 0.1007 mL 0.5035 mL 1.0069 mL 2.5173 mL
100 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0139 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Orcinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orcinol504-15-43,5-DihydroxytolueneFluorescent DyeTyrosinasep38 MAPKERKExtracellular signal regulated kinasesindicatortoxicglueresorcinolInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Orcinol
Cat. No.:
HY-D0168
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (394 KB) Français - FR (394 KB) Deutsch - DE (394 KB) Norwegian - NO (394 KB) Español - ES (394 KB) Swedish - SV (394 KB) Italian - IT (394 KB) Korean - KR (394 KB) Portuguese - PT (394 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.