504-15-4
Chemical Structure
Orcinol
Synonym(s): 3,5-Dihydroxytoluene
- CAS No.: 504-15-4
- Formula:C7H8O2
- Molecular Weight:124.14
IUPAC Name: 5-methylbenzene-1,3-diol
InChIKey: OIPPWFOQEKKFEE-UHFFFAOYSA-N
SMILES: OC1=CC(C)=CC(O)=C1
Biological Activity: Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases[1][2][3].
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Orcinol | 99.97% | Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases. | ||||||||||||||||||||
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- [1]. Murakami Y, et al. The Radical Scavenging Activity and Cytotoxicity of Resveratrol, Orcinol and 4-Allylphenol and their Inhibitory Effects on Cox-2 Gene Expression and Nf-κb Activation in RAW264.7 Cells Stimulated with Porphyromonas gingivalis-fimbriae. In Vivo. 2015 May-Jun;29(3):341-9. [Content Brief]
- [2]. Yu C L, et al. Orcinol inhibits melanogenesis in B16F10 cells via the upregulation of the MAPK/ERK signaling pathway[J]. Natural Product Communications, 2023, 18(3): 1934578X231156704.
- [3]. Edwards MJ, et al. Acid loads induced by the detoxification of plant secondary metabolites do not limit feeding by common brushtail possums (Trichosurus vulpecula). J Comp Physiol B. 2010 Feb;180(2):247-57. [Content Brief]
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