2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation GPCR/G Protein
  3. Radionuclide-Drug Conjugates (RDCs) CXCR
  4. Pentixafor

Pentixafor is a peptide that targets CXCR4. Pentixafor is capable of being labelled with 68Gallium (68Ga) for positron emission tomography (PET) imaging. Pentixafor can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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Pentixafor

Pentixafor Estructura química

No. CAS : 1341207-62-2

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Revisión del cliente

Based on 2 publication(s) in Google Scholar

Pentixafor Related Antibodies

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Descripciòn

Pentixafor is a peptide that targets CXCR4. Pentixafor is capable of being labelled with 68Gallium (68Ga) for positron emission tomography (PET) imaging[1][2][3][4]. Pentixafor can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

In Vitro

[18F]AlF-NOTA-Pentixather (195 pmol, 60 minutes) exhibits significant internalization and high cellular uptake in CXCR4-transfected Chem-1 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentixafor Related Antibodies
In Vivo

[68Ga]Pentixafor (15 MBq, intravenous injection, single dose) is suitable for PET imaging in the PC-3 prostate cancer xenograft model[2].
[18F]AlF-NOTA-Pentixather (0.30 MBq, intravenous injection, single dose) can target the CXCR4 receptor for specific PET imaging in the Daudi lymphoma xenograft SCID mouse model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 prostate cancer xenograft (nude mouse) model[2]
Dosage: 15 MBq (Pentixafor labeled with 68Gallium (68Ga), [68Ga]Pentixafor)
Administration: Intravenous injection (i.v., injection via tail vein), single dose
Result: Resulted in moderate contrast in PET imaging performed in the PC-3 tumor model.
Animal Model: Daudi lymphoma xenograft (SCID mouse) model[4]
Dosage: 0.30 MBq ([18F]AlF-NOTA-Pentixather, approx. 195 pmol/0.251 µg)
Administration: Intravenous injection (i.v.), single dose, imaging performed at 60 minutes post-injection
Result: Exhibited CXCR4-specific tumor accumulation, with low uptake in background organs.
Ensayo clínico
Peso molecular

1221.36

Fòrmula

C60H80N14O14
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

Cyclo{Arg-{2-Naph-Ala}-Gly-dTyr-dOrn(NMe)}-PAMBA-DOTA
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad
In Vitro: 

Methanol : ≥ 125 mg/mL (102.34 mM)

DMSO : 100 mg/mL (81.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8188 mL 4.0938 mL 8.1876 mL
5 mM 0.1638 mL 0.8188 mL 1.6375 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.79%

SDS (254 KB)

COA (254 KB) HNMR (386 KB) RP-HPLC (255 KB) MS (72 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 0.8188 mL 4.0938 mL 8.1876 mL 20.4690 mL
5 mM 0.1638 mL 0.8188 mL 1.6375 mL 4.0938 mL
10 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0469 mL
15 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3646 mL
20 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0234 mL
25 mM 0.0328 mL 0.1638 mL 0.3275 mL 0.8188 mL
30 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.6823 mL
40 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
50 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.4094 mL
60 mM 0.0136 mL 0.0682 mL 0.1365 mL 0.3411 mL
80 mM 0.0102 mL 0.0512 mL 0.1023 mL 0.2559 mL
Methanol 100 mM 0.0082 mL 0.0409 mL 0.0819 mL 0.2047 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentixafor1341207-62-2Radionuclide-Drug Conjugates (RDCs)CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsPETGalliumpeptideCXCR4-transfected Chem-1 cellsInhibitorinhibitorinhibit

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