2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Heme Oxygenase (HO) Interleukin Related
  4. Perfluorohexane

Perfluorohexane  (Synonyms: AF-0150)

製品番号: HY-109540 純度: 98.2%
COA 取扱説明書 Technical Support

Perfluorohexane (AF-0150) is a perfluorocarbon. Perfluorohexane is also an enhancer of high-intensity focused ultrasound (HIFU) therapy. Perfluorohexane increases HO-1 and IL-10. Perfluorohexane exerts an antioxidant effect. Perfluorohexane alleviates lung injury induced by LPS (HY-D1056A1). Perfluorohexane improves the efficiency and precision of HIFU and reduces damage to surrounding normal tissues. Perfluorohexane can be used in the study of acute lung injury.

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Perfluorohexane

Perfluorohexane 構造式

CAS 番号 : 355-42-0

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Liquid
5 g $25 在庫あり
10 g $40 在庫あり
50 g   お問い合わせ  

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Perfluorohexane 関連抗体

Top Publications Citing Use of Products

Heme Oxygenase (HO) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HO-1 HO-2

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Perfluorohexane (AF-0150) is a perfluorocarbon. Perfluorohexane is also an enhancer of high-intensity focused ultrasound (HIFU) therapy. Perfluorohexane increases HO-1 and IL-10. Perfluorohexane exerts an antioxidant effect. Perfluorohexane alleviates lung injury induced by LPS (HY-D1056A1). Perfluorohexane improves the efficiency and precision of HIFU and reduces damage to surrounding normal tissues. Perfluorohexane can be used in the study of acute lung injury[1][2][3].

体外実験

Perfluorohexane (12-36 h) shows no cytotoxicity to human mesothelial cells, does not induce cell activation, and does not significantly affect the expression of cell adhesion molecules ICAM-1, VCAM-1 and surfactant protein A[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Perfluorohexane 関連抗体
体内実験

Perfluorohexane (10 mL/kg; i.p.; every 2 h) attenuates Lipopolysaccharide (HY-D1056A1)-induced lung injury in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (4-6 months old, weighing 250-300 g); lipopolysaccharide-induced acute lung injury model[3]
Dosage: 10 mL/kg
Administration: Intraperitoneal injection; every 2 h.
Result: Decreased lung wet/dry weight ratio, malondialdehyde content, and myeloperoxidase activity.
Reduced tumor necrosis factor-α level and increased interleukin-10 level in bronchoalveolar lavage fluid.
Induced the expression of heme oxygenase-1.
分子量

338.04

分子式

C6F14
CAS 番号
Appearance

Liquid (Density: 1.665 g/cm3)

Color

Colorless to light yellow

SMILES

FC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (295.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9582 mL 14.7911 mL 29.5823 mL
5 mM 0.5916 mL 2.9582 mL 5.9165 mL
10 mM 0.2958 mL 1.4791 mL 2.9582 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 98.62%

COA (247 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9582 mL 14.7911 mL 29.5823 mL 73.9557 mL
5 mM 0.5916 mL 2.9582 mL 5.9165 mL 14.7911 mL
10 mM 0.2958 mL 1.4791 mL 2.9582 mL 7.3956 mL
15 mM 0.1972 mL 0.9861 mL 1.9722 mL 4.9304 mL
20 mM 0.1479 mL 0.7396 mL 1.4791 mL 3.6978 mL
25 mM 0.1183 mL 0.5916 mL 1.1833 mL 2.9582 mL
30 mM 0.0986 mL 0.4930 mL 0.9861 mL 2.4652 mL
40 mM 0.0740 mL 0.3698 mL 0.7396 mL 1.8489 mL
50 mM 0.0592 mL 0.2958 mL 0.5916 mL 1.4791 mL
60 mM 0.0493 mL 0.2465 mL 0.4930 mL 1.2326 mL
80 mM 0.0370 mL 0.1849 mL 0.3698 mL 0.9244 mL
100 mM 0.0296 mL 0.1479 mL 0.2958 mL 0.7396 mL
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Perfluorohexane Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perfluorohexane355-42-0AF-0150AF0150AF 0150Heme Oxygenase (HO)Interleukin RelatedHeme OxygenaseILHigh energy focused ultrasoundtissue necrosisenhancerultrasound imagingInhibitorinhibitorinhibit

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Perfluorohexane
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