Perhexiline

Name: Perhexiline
Brand: MedChemExpress
SKU: HY-B1334
Rating: 5.0 (6 reviews)

Cat. No.: HY-B1334 Pureza: 99.96%: Ficha de datos
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Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina.

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No. CAS : 6621-47-2

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 6 publication(s) in Google Scholar

Other Forms of Perhexiline:

Perhexiline maleate In-stock

6 Publications Citing Use of MCE Perhexiline

Histological Imaging/Staining

Cell Imaging/Staining

Bio/Physico-chemical Assay

Cell Proliferation/Viability Assay

: Perhexiline purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693.; Inhibition of CPT1A activity using Perhexiline maleate (0-10 μM, 24 h) and PD-L1 detection by western blotting in A375 cell.

: Perhexiline purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693.; A375 cells treated with Perhexiline maleate (0-10 μM) for 24 h, then co-cultured with or without activated T cells for 24 h to assess the killing effect.

: Perhexiline purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jan;15(1):133-150.; Results of H&E and Ki67 staining in representative A549 cells tumor sections of vehicle, perhexiline (10 mg/kg, ip, 3 days), and Perhexiline maleate (10 mg/kg) treated naked mice. Scale bar = 200 μm (H&E up).

: Perhexiline purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jan;15(1):133-150.; Perhexiline maleate (0-20 μM, 8 days) exhibited inhibition of colony formation in A549 and NCI-H1975 cells.

: Perhexiline purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jan;15(1):133-150.; Reversal relationship between LUAD GSFM pattern and Perhexiline maleate GSFM pattern.

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Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

CPT-1

CPT-2

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	11.3 3 Compound: Perhexiline	Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay	[PMID: 36793433]
HepG2	IC₅₀	11.3 3 Compound: Perhexiline	Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay	[PMID: 36793433]
HepG2	IC₅₀	11.3 3 Compound: Perhexiline	Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay	[PMID: 36793433]
KB	IC₅₀	14.8 3 Compound: 44	Cytotoxicity in human KB cells Cytotoxicity in human KB cells	[PMID: 21504156]
Vero	IC₅₀	6.38 3 Compound: Perhexiline	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730
KB	IC₅₀	14.8 3 Compound: 44	Cytotoxicity in human KB cells Cytotoxicity in human KB cells	[PMID: 21504156]
Vero	CC₅₀	8.67 3 Compound: Perhexiline	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	CC₅₀	8.67 3 Compound: Perhexiline	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	CC₅₀	8.67 3 Compound: Perhexiline	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	IC₅₀	6.38 3 Compound: Perhexiline	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730
Vero	IC₅₀	6.38 3 Compound: Perhexiline	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730

In Vitro

Perhexiline (5-25 μM, 2-6 h) reduces cell viability in HepG2 cells^[2].
Perhexiline (5-25 μM, 2-6 h) reduces cellular ATP content and Lactate dehydrogenase (LDH) release in HepG2 cells^[2].
Perhexiline (20 μM, 2 h) activates caspase 3/7 in HepG2 cells^[2].
Perhexiline (5-25 μM, 4 h) causes mitochondrial dysfunction in HepG2 cells^[2].
Perhexiline (5 μM, 48 h) selectively induces massive apoptosis in CLL cells (high expression of CPT)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	HepG2 cells
Concentration:	5, 10, 15, 25 μM
Incubation Time:	2, 4, 6 h
Result:	Induced time- and concentration-dependent cytotoxicity in hepatic cells.

Western Blot Analysis^[2]

Cell Line:	HepG2 cells
Concentration:	5, 10, 15, 25 μM
Incubation Time:	2 h
Result:	Reduced Bcl-2 and Mcl-1 level, and increased Bad level.

In Vivo

Perhexiline (200 mg/kg, p.o., daily for 8 weeks) reduces peripheral neural function in female DA rats^[4].
Perhexiline (80 mg/kg, oral gavage, for 3 days) demonstrates anti-tumor activity in glioblastoma mouse model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Orthotopic glioblastoma mouse model^[5]
Dosage:	80 mg/kg
Administration:	Oral gavage, for 3 days.
Result:	Reduces tumor size (MR imaging) and improves in overall survival.

Ensayo clínico

Peso molecular

277.49

Fòrmula

C₁₉H₃₅N

No. CAS

6621-47-2

Appearance

Solid

Color

White to off-white

SMILES

C1(CC(C2CCCCC2)C3CCCCC3)NCCCC1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : ≥ 100 mg/mL (360.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6037 mL	18.0187 mL	36.0373 mL
5 mM	0.7207 mL	3.6037 mL	7.2075 mL
10 mM	0.3604 mL	1.8019 mL	3.6037 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.96%

Select Batch:

Ficha de datos (277 KB) SDS (393 KB)

COA (247 KB) HNMR (389 KB) RP-HPLC (242 KB) MS (68 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. E. Marc Jolicoeur, et al. 27 - Refractory Angina. Chronic Coronary Artery Disease, 2018, 412-431.

[2]. Zhen Ren, et al. Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline. Toxicol In Vitro. 2020 Dec;69:104987. [Content Brief]

[3]. P-P Liu, et al. Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline. Oncogene. 2016 Oct 27;35(43):5663-5673. [Content Brief]

[4]. Giovanni Licari, et al. Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats. Pharmacol Res Perspect. 2018 Jun;6(3):e00406. [Content Brief]

[5]. Shiva Kant, et al. Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. Mol Cancer Ther. 2020 Jul;19(7):1415-1422. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6037 mL	18.0187 mL	36.0373 mL	90.0933 mL
	5 mM	0.7207 mL	3.6037 mL	7.2075 mL	18.0187 mL
	10 mM	0.3604 mL	1.8019 mL	3.6037 mL	9.0093 mL
	15 mM	0.2402 mL	1.2012 mL	2.4025 mL	6.0062 mL
	20 mM	0.1802 mL	0.9009 mL	1.8019 mL	4.5047 mL
	25 mM	0.1441 mL	0.7207 mL	1.4415 mL	3.6037 mL
	30 mM	0.1201 mL	0.6006 mL	1.2012 mL	3.0031 mL
	40 mM	0.0901 mL	0.4505 mL	0.9009 mL	2.2523 mL
	50 mM	0.0721 mL	0.3604 mL	0.7207 mL	1.8019 mL
	60 mM	0.0601 mL	0.3003 mL	0.6006 mL	1.5016 mL
	80 mM	0.0450 mL	0.2252 mL	0.4505 mL	1.1262 mL
	100 mM	0.0360 mL	0.1802 mL	0.3604 mL	0.9009 mL

Perhexiline Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perhexiline6621-47-2Carnitine Palmitoyltransferase (CPT)Mitochondrial MetabolismApoptosisCarnitine O-palmitoyltransferaseAnti-anginalcancerglioblastomaBBBmitochondrial dysfunctionHepG2CLL cellInhibitorinhibitorinhibit

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Perhexiline

Revisión del cliente

Other Forms of Perhexiline:

Perhexiline Related Antibodies

6 Publications Citing Use of MCE Perhexiline

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Perhexiline Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Perhexiline Related Classifications

Keywords:

Productos vistos recientemente:

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