6621-47-2
6621-47-2
Chemical Structure
Perhexiline
- CAS No.: 6621-47-2
- Formula:C19H35N
- Molecular Weight:277.49
IUPAC Name: 2-(2,2-dicyclohexylethyl)piperidine
InChIKey: CYXKNKQEMFBLER-UHFFFAOYSA-N
SMILES: C1(CC(C2CCCCC2)C3CCCCC3)NCCCC1
Biological Activity: Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina[1][2][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Perhexiline | 99.96% | Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina. | ||||||||||||||||||||
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References
- [1]. E. Marc Jolicoeur, et al. 27 - Refractory Angina. Chronic Coronary Artery Disease, 2018, 412-431.
- [2]. Zhen Ren, et al. Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline. Toxicol In Vitro. 2020 Dec;69:104987. [Content Brief]
- [5]. Shiva Kant, et al. Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. Mol Cancer Ther. 2020 Jul;19(7):1415-1422. [Content Brief]
Keywords
