1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-06761281

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively.

For research use only. We do not sell to patients.

PF-06761281 Chemical Structure

PF-06761281 Chemical Structure

CAS No. : 1854061-19-0

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10 mg USD 180 In-stock
25 mg USD 400 In-stock
50 mg USD 700 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].

IC50 & Target

IC50: 0.51 µM (HEKNaCT), 13.2 µM (HEKNaDC1), 14.1 µM (HEKNaDC3)[1]

In Vitro

PF-06761281 (Compound 4a) inhibits citrate uptake with IC50 values of 0.12, 0.21 and 0.74 µM in rat, mouse and human Heps[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

283.28

Formula

C13H17NO6

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (176.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5301 mL 17.6504 mL 35.3008 mL
5 mM 0.7060 mL 3.5301 mL 7.0602 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5301 mL 17.6504 mL 35.3008 mL 88.2519 mL
5 mM 0.7060 mL 3.5301 mL 7.0602 mL 17.6504 mL
10 mM 0.3530 mL 1.7650 mL 3.5301 mL 8.8252 mL
15 mM 0.2353 mL 1.1767 mL 2.3534 mL 5.8835 mL
20 mM 0.1765 mL 0.8825 mL 1.7650 mL 4.4126 mL
25 mM 0.1412 mL 0.7060 mL 1.4120 mL 3.5301 mL
30 mM 0.1177 mL 0.5883 mL 1.1767 mL 2.9417 mL
40 mM 0.0883 mL 0.4413 mL 0.8825 mL 2.2063 mL
50 mM 0.0706 mL 0.3530 mL 0.7060 mL 1.7650 mL
60 mM 0.0588 mL 0.2942 mL 0.5883 mL 1.4709 mL
80 mM 0.0441 mL 0.2206 mL 0.4413 mL 1.1031 mL
100 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8825 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PF-06761281 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PF-06761281
Cat. No.:
HY-120669
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