1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-06761281

PF-06761281 

Cat. No.: HY-120669
Handling Instructions

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively.

For research use only. We do not sell to patients.

PF-06761281 Chemical Structure

PF-06761281 Chemical Structure

CAS No. : 1854061-19-0

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Description

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].

IC50 & Target

IC50: 0.51 µM (HEKNaCT), 13.2 µM (HEKNaDC1), 14.1 µM (HEKNaDC3)[1]

In Vitro

PF-06761281 (Compound 4a) inhibits citrate uptake with IC50 values of 0.12, 0.21 and 0.74 µM in rat, mouse and human Heps[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

283.28

Formula

C13H17NO6

CAS No.
SMILES

O=C(O)[[email protected]](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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PF-06761281
Cat. No.:
HY-120669
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