2. Anti-infection
  3. Parasite
  4. PFK-IN-1

PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively.

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PFK-IN-1

PFK-IN-1 Estructura química

No. CAS : 735303-62-5

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  

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PFK-IN-1 Related Antibodies

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Descripciòn

PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively[1].

Cellular Effect
Cell Line Type Value Description References
MRC5 ED50
46 3
Compound: 1, MLS002158384-01
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
[PMID: 24900769]
MRC5 ED50
46 3
Compound: 1, MLS002158384-01
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
[PMID: 24900769]
Peso molecular

440.30

Fòrmula

C18H15Cl2N3O4S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(S(=O)(NC2=NOC(C)=C2)=O)C=C1)CC3=CC=C(Cl)C(Cl)=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : ≥ 125 mg/mL (283.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2712 mL 11.3559 mL 22.7118 mL
5 mM 0.4542 mL 2.2712 mL 4.5424 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2712 mL 11.3559 mL 22.7118 mL 56.7795 mL
5 mM 0.4542 mL 2.2712 mL 4.5424 mL 11.3559 mL
10 mM 0.2271 mL 1.1356 mL 2.2712 mL 5.6779 mL
15 mM 0.1514 mL 0.7571 mL 1.5141 mL 3.7853 mL
20 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.8390 mL
25 mM 0.0908 mL 0.4542 mL 0.9085 mL 2.2712 mL
30 mM 0.0757 mL 0.3785 mL 0.7571 mL 1.8926 mL
40 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4195 mL
50 mM 0.0454 mL 0.2271 mL 0.4542 mL 1.1356 mL
60 mM 0.0379 mL 0.1893 mL 0.3785 mL 0.9463 mL
80 mM 0.0284 mL 0.1419 mL 0.2839 mL 0.7097 mL
100 mM 0.0227 mL 0.1136 mL 0.2271 mL 0.5678 mL
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PFK-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PFK-IN-1735303-62-5Parasiterat and mouse liver microsomesInhibitorinhibitorinhibit

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Nombre del producto:
PFK-IN-1
Cat. No.:
HY-128268
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