2. Anti-infection
  3. Parasite
  4. PFK-IN-1

PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively.

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PFK-IN-1

PFK-IN-1 화학구조

CAS No. : 735303-62-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg   견적 받기  
200 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

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PFK-IN-1 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively[1].

Cellular Effect
Cell Line Type Value Description References
MRC5 ED50
46 3
Compound: 1, MLS002158384-01
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
[PMID: 24900769]
MRC5 ED50
46 3
Compound: 1, MLS002158384-01
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
[PMID: 24900769]
분자량

440.30

화학식

C18H15Cl2N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(S(=O)(NC2=NOC(C)=C2)=O)C=C1)CC3=CC=C(Cl)C(Cl)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 125 mg/mL (283.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2712 mL 11.3559 mL 22.7118 mL
5 mM 0.4542 mL 2.2712 mL 4.5424 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2712 mL 11.3559 mL 22.7118 mL 56.7795 mL
5 mM 0.4542 mL 2.2712 mL 4.5424 mL 11.3559 mL
10 mM 0.2271 mL 1.1356 mL 2.2712 mL 5.6779 mL
15 mM 0.1514 mL 0.7571 mL 1.5141 mL 3.7853 mL
20 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.8390 mL
25 mM 0.0908 mL 0.4542 mL 0.9085 mL 2.2712 mL
30 mM 0.0757 mL 0.3785 mL 0.7571 mL 1.8926 mL
40 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4195 mL
50 mM 0.0454 mL 0.2271 mL 0.4542 mL 1.1356 mL
60 mM 0.0379 mL 0.1893 mL 0.3785 mL 0.9463 mL
80 mM 0.0284 mL 0.1419 mL 0.2839 mL 0.7097 mL
100 mM 0.0227 mL 0.1136 mL 0.2271 mL 0.5678 mL
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PFK-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PFK-IN-1735303-62-5Parasiterat and mouse liver microsomesInhibitorinhibitorinhibit

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상품명:
PFK-IN-1
Cat. No.:
HY-128268
수량:
MCE Japan Authorized Agent:

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