2. Others NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Reactive Oxygen Species (ROS) Environmental Pollutants Apoptosis
  4. Propyl gallate

没食子酸プロピル  (Synonyms: Propyl gallate)

製品番号: HY-N0524 純度: 99.74%
COA 取扱説明書 Technical Support

Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. Propyl gallate exhibits anti-inflammatory, antitumor and cardioprotective activities.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Propyl gallate

没食子酸プロピル 構造式

CAS 番号 : 121-79-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
1 g $30 在庫あり
5 g $60 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Propyl gallate:

没食子酸プロピル 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. Propyl gallate exhibits anti-inflammatory, antitumor and cardioprotective activities[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
800 3
Compound: G3
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
[PMID: 23291333]
HeLa IC50
800 3
Compound: G3
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
[PMID: 23291333]
L929 IC50
40 3
Compound: G3
Cytotoxicity against mouse L929 cells
Cytotoxicity against mouse L929 cells
[PMID: 23291333]
L929 IC50
40 3
Compound: G3
Cytotoxicity against mouse L929 cells
Cytotoxicity against mouse L929 cells
[PMID: 23291333]
体外実験

Propyl gallate (100-1600 μM, 24 h) increases the ROS level, and decreases the level of glutathione (GSH)[3].
Propyl gallate (0-1600 μM, 72 h) inhibits the cancer cell growth of Calu-6 and A549 (IC50 about 50 μM and 800 μM at 24 h), arrests the cell cycle at G1 phase, and induces apoptosis through the mitochondrial pathway and cell death receptor pathway[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

没食子酸プロピル 関連抗体

Cell Cycle Analysis[4]

Cell Line: Calu-6 and A549
Concentration: 0-200 μM
Incubation Time: 72 h
Result: Arrested the cell cycle at G1 phase.

Western Blot Analysis[4]

Cell Line: Calu-6 and A549
Concentration: 0-800 μM
Incubation Time: 24 h
Result: Downregulated Bcl-2 levels, upregulated cleaved PARP level.
体内実験

Propyl gallate (10-300 mg/kg, po, 28 days) inhibits cardiac enlargement in dilated cardiomyopathy (DCM) mice, prevents left ventricular dilatation and systolic dysfunction, increases myocardial contractility by increasing the sensitivity of myofilaments in myocardial fibers to Ca2+[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DCM mouse models[5]
Dosage: 10-300 mg/kg
Administration: po, 28 days
Result: Inhibited cardiac enlargement, decreased left ventricular end-diastolic diameter (LVEDD) and increased ejection fraction (EF).
分子量

212.20

分子式

C10H12O5
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCC)C1=CC(O)=C(O)C(O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (942.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7125 mL 23.5627 mL 47.1254 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (23.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (23.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.74%

COA (246 KB) HNMR (240 KB) LCMS (95 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7125 mL 23.5627 mL 47.1254 mL 117.8134 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL 23.5627 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL 11.7813 mL
15 mM 0.3142 mL 1.5708 mL 3.1417 mL 7.8542 mL
20 mM 0.2356 mL 1.1781 mL 2.3563 mL 5.8907 mL
25 mM 0.1885 mL 0.9425 mL 1.8850 mL 4.7125 mL
30 mM 0.1571 mL 0.7854 mL 1.5708 mL 3.9271 mL
40 mM 0.1178 mL 0.5891 mL 1.1781 mL 2.9453 mL
50 mM 0.0943 mL 0.4713 mL 0.9425 mL 2.3563 mL
60 mM 0.0785 mL 0.3927 mL 0.7854 mL 1.9636 mL
80 mM 0.0589 mL 0.2945 mL 0.5891 mL 1.4727 mL
100 mM 0.0471 mL 0.2356 mL 0.4713 mL 1.1781 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Propyl gallate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propyl gallate121-79-9Reactive Oxygen Species (ROS)Environmental PollutantsApoptosisEnvironmental ContaminantsantioxidantInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Propyl gallate
製品番号:
HY-N0524
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.