2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  4. VEGF & VEGFR Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. VEGFR

VEGFR

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The vascular endothelial growth factor (VEGF) family of receptors (VEGFR) consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2). VEGFRs are typical tyrosine kinase receptors (TKRs) consist of an extracellular component with seven immunoglobulin-like domains, a single transmembrane domain, and a split tyrosine kinase domain. VEGF-A, -B, and PlGF bind to VEGFR-1; VEGFR-2 is stimulated by VEGF-A, -C, -D and -E; VEGFR-3 is specific for VEGF-C and -D. According to the consensus model for ligand-induced activation of RTKs, VEGF binds to a cognate VEGFR to induce receptor dimerization, leading to protein kinase activation and autophosphorylation of tyrosine residues in the receptor intracellular domains, and initiation of signaling pathways, such as PI3K/AKT and MAPK/ERK1/2. VEGFR signaling is tightly regulated at numerous different levels, including receptor expression levels, the availability and affinities for binding of its different ligands, the presence of VEGF-binding co-receptors, non-VEGF-binding auxiliary proteins and inactivating tyrosine phosphatases, the rate of receptor cellular uptake, extent of degradation and speed of recycling.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70552
    VEGFR-2 Protein, Human (HEK293, His)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR2; VEGF R2

    		Human HEK293
    VEGFR-2 is a tyrosine-protein kinase of the cell surface receptors of VEGFA, VEGFC, and VEGFD that mediates activation of the MAPK1/ERK2, MAPK3/ERK1, and MAP kinase signaling pathways, as well as the AKT1 signaling pathway. VEGFR-2 can promote the proliferation, survival, migration and differentiation of endothelial cells. Overexpression of VEGFR-2 is associated with the development of tumors. VEGFR-2 Protein, Human (HEK293, His) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-2 Protein, Human (HEK293, His) is 745 a.a., with molecular weight of 84-140 kDa.
  • HY-P70635
    VEGFR-2 Protein, Human (745a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR2; VEGF R2

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (745a.a, HEK293, Fc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-2 Protein, Human (745a.a, HEK293, Fc) is 745 a.a., with molecular weight of 150-160 kDa.
  • HY-P78230
    VEGFR-1 Protein, Human (Biotinylated, HEK293, His-Avi)

    FLT; FLT1; Flt-1; FRT; VEGF R1; VEGFR1

    		Human HEK293
    The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGFR-1 Protein, Human (Biotinylated, HEK293, His-Avi) is 730 a.a., with molecular weight of 100-120 kDa.
  • HY-P78231
    VEGFR-2 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD309; KDR; VEGFR; VEGFR2; VEGFR-21; FLK1; KRD1; Ly73

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGFR-2 Protein, Human (Biotinylated, HEK293, His-Avi) is 745 a.a., with molecular weight of 115-140 kDa.
  • HY-P74467
    VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc)

    Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4

    		Mouse HEK293
    VEGFR-3/FLT4 proteins are tyrosine protein kinase receptors for VEGFC and VEGFD and are critical in adult lymphangiogenesis and embryonic vascular development. It promotes endothelial cell function, angiogenesis, and forms a positive feedback loop that increases VEGFC production. VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc) is 751 a.a., with molecular weight of 115-160 kDa.
  • HY-P74468
    VEGFR-3/FLT4 Protein, Human (HEK293, His)

    Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4

    		Human HEK293
    VEGFR-2 protein is an important tyrosine protein kinase receptor that serves as a cell surface receptor for VEGFA, VEGFC and VEGFD to regulate angiogenesis, blood vessel development and embryonic hematopoiesis. It enhances endothelial cell proliferation, survival, migration and differentiation. VEGFR-3/FLT4 Protein, Human (HEK293, His) is the recombinant human-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-3/FLT4 Protein, Human (HEK293, His) is 752 a.a., with molecular weight of ~130 kDa.
  • HY-P72429
    VEGFR-2 Protein, Mouse (743a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 2; VEGFR-2; FLK-1; NYK; CD309

    		Mouse HEK293
    VEGFR-2 protein is an important tyrosine protein kinase receptor. As a cell surface receptor for VEGFA, VEGFC and VEGFD, it plays an important role in the regulation of angiogenesis, vascular development, permeability and embryonic hematopoiesis. It actively promotes endothelial cell proliferation, survival, migration, differentiation, and actin cytoskeletal reorganization. VEGFR-2 Protein, Mouse (743a.a, HEK293, Fc) is the recombinant mouse-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-2 Protein, Mouse (743a.a, HEK293, Fc) is 743 a.a., with molecular weight of ~138.21 kDa.
  • HY-P70636
    VEGFR-1 Protein, Human (730a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular permeability factor receptor

    		Human HEK293
    The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (730a.a, HEK293, Fc) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-1 Protein, Human (730a.a, HEK293, Fc) is 730 a.a., with molecular weight of 150-175 kDa.
  • HY-P73553
    VEGFR-1 Protein, Mouse (HEK293, His)

    Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1

    		Mouse HEK293
    The VEGFR-1 protein is a key tyrosine protein kinase receptor. VEGFR-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived VEGFR-1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of VEGFR-1 Protein, Mouse (HEK293, His) is 737 a.a., with molecular weight of ~130 kDa.
  • HY-P73552
    VEGFR-1 Protein, Rat (HEK293, His)

    Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1

    		Rat HEK293
    VEGFR-1 protein is a tyrosine protein kinase receptor for VEGFA, VEGFB, and PGF and is critical for embryonic vasculature development, angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer invasion. It actively regulates postnatal retinal vitreous vascular degeneration and may act as a negative regulator of embryonic angiogenesis. VEGFR-1 Protein, Rat (HEK293, His) is the recombinant rat-derived VEGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-1 Protein, Rat (HEK293, His) is 736 a.a., with molecular weight of ~110-130 kDa.
  • HY-P74470
    VEGFR-2 Protein, Rat (HEK293, His)

    Vascular endothelial growth factor receptor 2; VEGFR-2; FLK-1; CD309

    		Rat HEK293
    VEGFR-2 Protein is a type III receptor tyrosine kinase, also known as the receptor for vascular endothelial growth factor 2. VEGFR-2 Protein mediates vascular endothelial growth factor (VEGF)-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting, and plays a key role in angiogenesis and vasculogenesis. VEGFR-2 Protein, Rat (HEK293, His) is the recombinant rat-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-2 Protein, Rat (HEK293, His) is 741 a.a., with molecular weight of ~115-180 kDa.
  • HY-P74473
    VEGFR-2 Protein, Cynomolgus (HEK293, His)

    Vascular endothelial growth factor receptor 2; VEGFR-2; FLK-1; CD309

    		Cynomolgus HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-2 Protein, Cynomolgus (HEK293, His) is 745 a.a., with molecular weight of ~115-180 kDa.
  • HY-P73064
    VEGFR-1 Protein, Human (328a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1

    		Human HEK293
    The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (328a.a, HEK293, Fc) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-1 Protein, Human (328a.a, HEK293, Fc) is 328 a.a., with molecular weight of ~61.1 kDa.
  • HY-P73065
    VEGFR-1 Protein, Human (328a.a, HEK293, His)

    Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1

    		Human HEK293
    The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (328a.a, HEK293, His) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-1 Protein, Human (328a.a, HEK293, His) is 328 a.a., with molecular weight of ~35.6 kDa.
  • HY-P73476
    VEGFR-2 Protein, Human (327a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; FLK-1; CD309

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (327a.a, HEK293, Fc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-2 Protein, Human (327a.a, HEK293, Fc) is 327 a.a., with molecular weight of ~61.5 kDa.
  • HY-P73477
    VEGFR-2 Protein, Human (208a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; FLK-1; CD309

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (208a.a, HEK293, Fc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VEGFR-2 Protein, Human (208a.a, HEK293, Fc) is 208 a.a., with molecular weight of ~50.4 kDa.
  • HY-P73530
    VEGFR-2 Protein, Human (745a.a, HEK293, His)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; FLK-1; CD309

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (745a.a, HEK293, His) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGFR-2 Protein, Human (745a.a, HEK293, His) is 745 a.a., with molecular weight of ~84.6 kDa.
  • HY-P73554
    VEGFR-1 Protein, Human (756a.a, HEK293, His)

    Vascular endothelial growth factor receptor 1; FLT; FLT1; FRT; VEGFR-1

    		Human HEK293
    The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (756a.a, HEK293, His) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-1 Protein, Human (756a.a, HEK293, His) is 756 a.a., with molecular weight of 110-120 kDa.
  • HY-P74472
    VEGFR-2 Protein, Mouse (Biotinylated, HEK293, His)

    Vascular endothelial growth factor receptor 2; VEGFR-2; FLK-1; CD309

    		Mouse HEK293
    VEGFR-2 protein is an important tyrosine protein kinase receptor. As a cell surface receptor for VEGFA, VEGFC and VEGFD, it plays an important role in the regulation of angiogenesis, vascular development, permeability and embryonic hematopoiesis. It actively promotes endothelial cell proliferation, survival, migration, differentiation, and actin cytoskeletal reorganization. VEGFR-2 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-2 Protein, Mouse (Biotinylated, HEK293, His) is 762 a.a., with molecular weight of ~84.5 kDa.
  • HY-P78536
    VEGFR-2 Protein, Human (HEK293, mFc)

    CD309; KDR; VEGFR; VEGFR2; VEGFR-21; FLK1; KRD1; Ly73

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (HEK293, mFc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of VEGFR-2 Protein, Human (HEK293, mFc) is 745 a.a., with molecular weight of 150-200 kDa.
Cat. No. Product Name Effect Purity