2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (±)-Coniine hydrochloride

(±)-Coniine hydrochloride  (Synonyms: 2-Propylpiperidine hydrochloride)

Cat. No.: HY-W099757 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

(±)-Coniine hydrochloride

(±)-Coniine hydrochloride 화학구조

CAS No. : 15991-59-0

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of (±)-Coniine hydrochloride:

(±)-Coniine hydrochloride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg[1].

IC50 & Target

EC50: 0.3 mM (nAChR)[1]
In Vivo

(±)-Coniine hydrochloride (compound 1) (0.05 mg-0.2 mg; i.v.) shows acute toxicity with an LD50 value of 7.7 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 15-20 g, Swiss-Webster male mice[1]
Dosage: 0.05 mg-0.2 mg
Administration: I.v.
Result: Clinical signs was almost immediate after injection, beginning with piloerection, tail flicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
분자량

163.69

화학식

C8H18ClN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCC1CCCCN1.Cl
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

DMSO : 25 mg/mL (152.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1091 mL 30.5455 mL 61.0911 mL
5 mM 1.2218 mL 6.1091 mL 12.2182 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.1091 mL 30.5455 mL 61.0911 mL 152.7277 mL
5 mM 1.2218 mL 6.1091 mL 12.2182 mL 30.5455 mL
10 mM 0.6109 mL 3.0546 mL 6.1091 mL 15.2728 mL
15 mM 0.4073 mL 2.0364 mL 4.0727 mL 10.1818 mL
20 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6364 mL
25 mM 0.2444 mL 1.2218 mL 2.4436 mL 6.1091 mL
30 mM 0.2036 mL 1.0182 mL 2.0364 mL 5.0909 mL
40 mM 0.1527 mL 0.7636 mL 1.5273 mL 3.8182 mL
50 mM 0.1222 mL 0.6109 mL 1.2218 mL 3.0546 mL
60 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5455 mL
80 mM 0.0764 mL 0.3818 mL 0.7636 mL 1.9091 mL
100 mM 0.0611 mL 0.3055 mL 0.6109 mL 1.5273 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(±)-Coniine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Coniine15991-59-02-PropylpiperidinenAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
(±)-Coniine hydrochloride
Cat. No.:
HY-W099757
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (481 KB) Français - FR (481 KB) Deutsch - DE (481 KB) Norwegian - NO (481 KB) Español - ES (481 KB) Swedish - SV (481 KB) Italian - IT (481 KB) Korean - KR (481 KB) Portuguese - PT (481 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.