(±)-Coniine (Synonyms: 2-Propylpiperidine)

Cat. No.: HY-121229A: Data Sheet Handling Instructions
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(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg.

For research use only. We do not sell to patients.

(±)-Coniine Chemical Structure

CAS No. : 3238-60-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of (±)-Coniine:

(±)-Coniine hydrochloride In-stock

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Description

(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg^[1]^[2].

Molecular Weight

127.23

Formula

C₈H₁₇N

CAS No.

3238-60-6

Appearance

Liquid

SMILES

CCCC1NCCCC1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (785.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8598 mL	39.2989 mL	78.5978 mL
5 mM	1.5720 mL	7.8598 mL	15.7196 mL
10 mM	0.7860 mL	3.9299 mL	7.8598 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (19.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (19.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (19.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee ST, et al. Stereoselective potencies and relative toxicities of coniine enantiomers. Chem Res Toxicol. 2008 Oct;21(10):2061-4. [Content Brief]

[2]. B T Green, et al. Complete Inhibition of Fetal Movement in the Day 40 Pregnant Goat Model by the Piperidine Alkaloid Anabasine but Not Related Alkaloids. Toxicon. 2018 Mar 15;144:61-67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.8598 mL	39.2989 mL	78.5978 mL	196.4945 mL
	5 mM	1.5720 mL	7.8598 mL	15.7196 mL	39.2989 mL
	10 mM	0.7860 mL	3.9299 mL	7.8598 mL	19.6495 mL
	15 mM	0.5240 mL	2.6199 mL	5.2399 mL	13.0996 mL
	20 mM	0.3930 mL	1.9649 mL	3.9299 mL	9.8247 mL
	25 mM	0.3144 mL	1.5720 mL	3.1439 mL	7.8598 mL
	30 mM	0.2620 mL	1.3100 mL	2.6199 mL	6.5498 mL
	40 mM	0.1965 mL	0.9825 mL	1.9649 mL	4.9124 mL
	50 mM	0.1572 mL	0.7860 mL	1.5720 mL	3.9299 mL
	60 mM	0.1310 mL	0.6550 mL	1.3100 mL	3.2749 mL
	80 mM	0.0982 mL	0.4912 mL	0.9825 mL	2.4562 mL
	100 mM	0.0786 mL	0.3930 mL	0.7860 mL	1.9649 mL

(±)-Coniine Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Coniine3238-60-62-PropylpiperidinenAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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(±)-Coniine (Synonyms: 2-Propylpiperidine)

Other Forms of (±)-Coniine:

(±)-Coniine Related Antibodies

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Biological Activity

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