2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (±)-Coniine hydrochloride

(±)-Coniine hydrochloride  (Synonyms: 2-Propylpiperidine hydrochloride)

Cat. No.: HY-W099757 Purity: ≥98.0%
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(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.

For research use only. We do not sell to patients.

(±)-Coniine hydrochloride Chemical Structure

(±)-Coniine hydrochloride Chemical Structure

CAS No. : 15991-59-0

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Based on 1 publication(s) in Google Scholar

Other Forms of (±)-Coniine hydrochloride:

(±)-Coniine hydrochloride Related Antibodies

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Description

(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg[1].

IC50 & Target

EC50: 0.3 mM (nAChR)[1]
In Vivo

(±)-Coniine hydrochloride (compound 1) (0.05 mg-0.2 mg; i.v.) shows acute toxicity with an LD50 value of 7.7 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 15-20 g, Swiss-Webster male mice[1]
Dosage: 0.05 mg-0.2 mg
Administration: I.v.
Result: Clinical signs was almost immediate after injection, beginning with piloerection, tail flicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
Molecular Weight

163.69

Formula

C8H18ClN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCC1CCCCN1.Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (152.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1091 mL 30.5455 mL 61.0911 mL
5 mM 1.2218 mL 6.1091 mL 12.2182 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.1091 mL 30.5455 mL 61.0911 mL 152.7277 mL
5 mM 1.2218 mL 6.1091 mL 12.2182 mL 30.5455 mL
10 mM 0.6109 mL 3.0546 mL 6.1091 mL 15.2728 mL
15 mM 0.4073 mL 2.0364 mL 4.0727 mL 10.1818 mL
20 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6364 mL
25 mM 0.2444 mL 1.2218 mL 2.4436 mL 6.1091 mL
30 mM 0.2036 mL 1.0182 mL 2.0364 mL 5.0909 mL
40 mM 0.1527 mL 0.7636 mL 1.5273 mL 3.8182 mL
50 mM 0.1222 mL 0.6109 mL 1.2218 mL 3.0546 mL
60 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5455 mL
80 mM 0.0764 mL 0.3818 mL 0.7636 mL 1.9091 mL
100 mM 0.0611 mL 0.3055 mL 0.6109 mL 1.5273 mL
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(±)-Coniine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Coniine15991-59-02-PropylpiperidinenAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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