(±)-Coniine hydrochloride
Based on 1 Customer Validation
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 15991-59-0
- Formula: C8H18ClN
- Molecular Weight:163.69
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 0.3 mM (nAChR)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:15-20 g, Swiss-Webster male mice[1]
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Dosage:0.05 mg-0.2 mg
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Administration:I.v.
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Result:Clinical signs was almost immediate after injection, beginning with piloerection, tail flicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
Chemical Information
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CAS No. 15991-59-0
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Appearance Solid
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Molecular Weight 163.69
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Formula C8H18ClN
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Color White to off-white
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SMILES
CCCC1CCCCN1.Cl
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Synonyms
2-Propylpiperidine hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 25 mg/mL (152.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.1091 mL | 30.5455 mL | 61.0911 mL | 152.7277 mL |
| 5 mM | 1.2218 mL | 6.1091 mL | 12.2182 mL | 30.5455 mL | |
| 10 mM | 0.6109 mL | 3.0546 mL | 6.1091 mL | 15.2728 mL | |
| 15 mM | 0.4073 mL | 2.0364 mL | 4.0727 mL | 10.1818 mL | |
| 20 mM | 0.3055 mL | 1.5273 mL | 3.0546 mL | 7.6364 mL | |
| 25 mM | 0.2444 mL | 1.2218 mL | 2.4436 mL | 6.1091 mL | |
| 30 mM | 0.2036 mL | 1.0182 mL | 2.0364 mL | 5.0909 mL | |
| 40 mM | 0.1527 mL | 0.7636 mL | 1.5273 mL | 3.8182 mL | |
| 50 mM | 0.1222 mL | 0.6109 mL | 1.2218 mL | 3.0546 mL | |
| 60 mM | 0.1018 mL | 0.5091 mL | 1.0182 mL | 2.5455 mL | |
| 80 mM | 0.0764 mL | 0.3818 mL | 0.7636 mL | 1.9091 mL | |
| 100 mM | 0.0611 mL | 0.3055 mL | 0.6109 mL | 1.5273 mL |
(±)-Coniine hydrochloride Related Classifications
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