2. GPCR/G Protein Immunology/Inflammation
  3. Leukotriene Receptor FLAP
  4. (S)-Veliflapon

(S)-Veliflapon  (Synonyms: (S)-BAY X 1005; (S)-DG-031)

製品番号: HY-14165A 純度: 99.25%
COA 取扱説明書 Technical Support

(S)-Veliflapon ((S)-BAY X 1005) is an orally active inhibitor of leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP). (S)-Veliflapon inhibits the formation of leukotriene B4 (LTB4) in rat, mouse and human leukocytes with IC50 values of 0.026 µM, 0.039 µM and 0.22 µM respectively. (S)-Veliflapon showes enantioselectivity in human whole blood.

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(S)-Veliflapon

(S)-Veliflapon 構造式

CAS 番号 : 128253-32-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 在庫あり
Solution
10 mM * 1 mL in DMSO USD 275 在庫あり
Solid
5 mg $250 在庫あり
10 mg $400 在庫あり
25 mg $800 在庫あり
50 mg $1280 在庫あり
100 mg $2050 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of (S)-Veliflapon:

(S)-Veliflapon 関連抗体

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Leukotriene Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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製品説明

(S)-Veliflapon ((S)-BAY X 1005) is an orally active inhibitor of leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP). (S)-Veliflapon inhibits the formation of leukotriene B4 (LTB4) in rat, mouse and human leukocytes with IC50 values of 0.026 µM, 0.039 µM and 0.22 µM respectively. (S)-Veliflapon showes enantioselectivity in human whole blood[1][2][3].

体外実験

(S)-Viliflapon decreases leukotriene B4 (LTB4) synthesis in human whole blood with dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Veliflapon 関連抗体
分子量

361.43

分子式

C23H23NO3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](C1CCCC1)C(C=C2)=CC=C2OCC3=NC4=CC=CC=C4C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (276.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7668 mL 13.8339 mL 27.6679 mL
5 mM 0.5534 mL 2.7668 mL 5.5336 mL
10 mM 0.2767 mL 1.3834 mL 2.7668 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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濃度 （終了）

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体積 （終了）

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7668 mL 13.8339 mL 27.6679 mL 69.1697 mL
5 mM 0.5534 mL 2.7668 mL 5.5336 mL 13.8339 mL
10 mM 0.2767 mL 1.3834 mL 2.7668 mL 6.9170 mL
15 mM 0.1845 mL 0.9223 mL 1.8445 mL 4.6113 mL
20 mM 0.1383 mL 0.6917 mL 1.3834 mL 3.4585 mL
25 mM 0.1107 mL 0.5534 mL 1.1067 mL 2.7668 mL
30 mM 0.0922 mL 0.4611 mL 0.9223 mL 2.3057 mL
40 mM 0.0692 mL 0.3458 mL 0.6917 mL 1.7292 mL
50 mM 0.0553 mL 0.2767 mL 0.5534 mL 1.3834 mL
60 mM 0.0461 mL 0.2306 mL 0.4611 mL 1.1528 mL
80 mM 0.0346 mL 0.1729 mL 0.3458 mL 0.8646 mL
100 mM 0.0277 mL 0.1383 mL 0.2767 mL 0.6917 mL
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(S)-Veliflapon Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Veliflapon128253-32-7(S)-BAY X 1005 (S)-DG-031Leukotriene ReceptorFLAP5-lipoxygenase-activating protein5-LO activating proteinLTB4VolunteersInhibitorinhibitorinhibit

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製品名:
(S)-Veliflapon
製品番号:
HY-14165A
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