2. PROTAC Protein Tyrosine Kinase/RTK Apoptosis
  3. PROTACs VEGFR Ephrin Receptor Apoptosis
  4. SA-VA

SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase.

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SA-VA

SA-VA Chemische Struktur

CAS. Nr. : 3058085-77-8

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SA-VA Related Antibodies

Top Publications Citing Use of Products

Alle PROTACs Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Alle VEGFR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

Alle Ephrin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
EphB EphA

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Beschreibung

SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase[1].

IC50 & Target[1]

VHL

 

VEGFR-2

 

EphB4

 

Molekulargewicht

1044.54

Formel

C50H53ClF3N11O7S
CAS. Nr.
SMILES

O=C(NCC1=CN(CCCCC(N[C@@H](C(C)(C)C)C(N2[C@H](C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C2)=O)=O)N=N1)C5=NC=CC(OC6=CC=C(NC(NC7=CC=C(Cl)C(C(F)(F)F)=C7)=O)C=C6)=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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SA-VA Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SA-VA3058085-77-8PROTACsVEGFREphrin ReceptorApoptosisVascular endothelial growth factor receptorPROTACVEGFR-2EphB4 proteinsclick reactioncopperInhibitorinhibitorinhibit

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