Salvinorin B 

Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC₅₀ of 248 nM and K_i of 2.95 μM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for the researches of inflammation, immunology and neurological disease, such as neuropathic pain, multiple sclerosis and anxiety^{[1][2][3][4][5]}.

Salvinorin B is inert in vivo^[1].
Salvinorin B (β-tetrahydropyran Salvinorin B) (1-2 mg/kg, i.p.) reduces inflammation in formalin-induced inflammatory pain model models^[2].
Salvinorin B (β-tetrahydropyran Salvinorin B) (2 mg/kg, s.c.) supresses both mechanical and cold allodynia in Paclitaxel (HY-B0015)-induced neuropathic pain mice model^[2].
Salvinorin B (ethoxymethyl ether Salvinorin B) (0.1-0.3 mg/kg, i.p., daily) decreased disease severity in multiple sclerosis mice models^[3].
Salvinorin B (2-O-salvinorin B benzofuran-2-carboxylate) (1-30 mg/kg, p.o.) shows antinociceptive and anxiolytic-like effects in mice nociception and anxiety models^[4].
Salvinorin B (methyl ester Sal B) (0.3 mg/kg, i.p.) attenuates cocaine-induced hyperactivity and behavioral sensitization to cocaine^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

390.43

C₂₁H₂₆O₇

92545-30-7

Solid

White to off-white

C[C@@]12[C@@]3([C@](CC[C@]1(C(O[C@@H](C2)C4=COC=C4)=O)[H])(C)[C@H](C(OC)=O)C[C@@H](C3=O)O)[H]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Vardy E, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.  [Content Brief]

  [2]. Paton KF, et al. The analgesic and anti-inflammatory effects of Salvinorin A analogue β-tetrahydropyran Salvinorin B in mice. Eur J Pain. 2017 Jul;21(6):1039-1050.  [Content Brief]

  [3]. Paton KF, et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis. Front Neurol. 2021 Dec 20;12:782190.  [Content Brief]

  [4]. Moreira CVL, et al. Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects. Fitoterapia. 2023 Jun;167:105488.  [Content Brief]

  [5]. Kivell BM, et al. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules. 2018 Oct 11;23(10):2602.  [Content Brief]