2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Phosphodiesterase (PDE) Aurora Kinase
  4. SAR156497

SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values ​​of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC50 value of 4 μM. SAR156497 can be used in anticancer research.

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SAR156497

SAR156497 構造式

CAS 番号 : 1256137-14-0

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SAR156497 関連抗体

Top Publications Citing Use of Products

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Aurora Kinase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aurora Kinase Aurora A Aurora B Aurora C

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製品説明

SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values ​​of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC50 value of 4 μM. SAR156497 can be used in anticancer research[1].

IC50 & Target

PDE3

4 μM (IC50)

Aurora A

0.6 nM (IC50)

Aurora B

1 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
3.714 μM
Compound: SAR156497
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
HEK293 IC50
5.864 μM
Compound: SAR156497
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
HeLa IC50
0.00611 μM
Compound: SAR156497
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
HeLa IC50
67 nM
Compound: 47
Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis
Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis
[PMID: 25369539]
PBMC IC50
>10 μM
Compound: 47
Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay
Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay
[PMID: 25369539]
PC-3 IC50
12.58 μM
Compound: SAR156497
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
分子量

468.50

分子式

C27H24N4O4
CAS 番号
SMILES

O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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SAR156497 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR1564971256137-14-0SAR 156497SAR-156497Phosphodiesterase (PDE)Aurora KinaseInhibitorinhibitorinhibit

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製品名:
SAR156497
製品番号:
HY-12476
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