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α-Linolenic acid

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By Targets:	Akt (6) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (1) Caspase (1) Dopamine Receptor (1) Drug Derivative (2) Endogenous Metabolite (3) Environmental Pollutants (2) ERK (1) Ferroptosis (1) GLUT (1) Herbicide (1) Isotope-Labeled Compounds (5) JAK (1) JNK (1) Lipoxygenase (1) Nucleoside Antimetabolite/Analog (2) p38 MAPK (1) PI3K (6) PKC (1) PPAR (1) Proteasome (1) Reference Standards (2) STAT (1) Tau Protein (1) TNF Receptor (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (7) Infection (1) Inflammation/Immunology (2) Metabolic Disease (10) Neurological Disease (2)

By Targets:

Akt (6)

Apoptosis (1)

Bacterial (1)

Biochemical Assay Reagents (1)

Caspase (1)

Dopamine Receptor (1)

Drug Derivative (2)

Endogenous Metabolite (3)

Environmental Pollutants (2)

ERK (1)

Ferroptosis (1)

GLUT (1)

Herbicide (1)

Isotope-Labeled Compounds (5)

JAK (1)

JNK (1)

Lipoxygenase (1)

Nucleoside Antimetabolite/Analog (2)

p38 MAPK (1)

PI3K (6)

PKC (1)

PPAR (1)

Proteasome (1)

Reference Standards (2)

STAT (1)

Tau Protein (1)

TNF Receptor (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (7)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (10)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0728

α-Linolenic acid Maximum Cited Publications 11 Publications Verification ALA free base; C18:3 (9Z,12Z,15Z) free base; C18:3 n-3 free base	Environmental Pollutants Akt PI3K	Cardiovascular Disease Cancer
α-Linolenic acid (ALA (free base); C18:3 (9Z,12Z,15Z) (free base); C18:3 n-3 (free base)) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-N0728S3

α-Linolenic acid-13C18	Isotope-Labeled Compounds PI3K Akt	Cardiovascular Disease Cancer
α-Linolenic acid- ¹³C₁₈ is the ¹³C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-W698249

Ferrous gluconate	Ferroptosis Bacterial	Cardiovascular Disease Infection
Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe ²⁺ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to E. coli infection and iron deficiency anemia .

HY-N0728S

α-Linolenic acid-d5	Isotope-Labeled Compounds PI3K Akt	Cardiovascular Disease Cancer
α-Linolenic acid-d₅ is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	TNF Receptor GLUT Proteasome Tau Protein PKC	Neurological Disease Metabolic Disease Inflammation/Immunology
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-122464S2

(±)-Jasmonic acid-d5	Isotope-Labeled Compounds	Others
(±)-Jasmonic acid-d₅ is the deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.

HY-N0728R

α-Linolenic acid (Standard) Maximum Cited Publications 11 Publications Verification	Reference Standards PI3K Akt	Cardiovascular Disease Cancer
α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-145512

N-(α-Linolenoyl) tyrosine NLT	Dopamine Receptor	Neurological Disease
N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Lipoxygenase	Metabolic Disease
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-N0728A

α-Linolenic acid sodium Maximum Cited Publications 11 Publications Verification ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3	Environmental Pollutants Akt PI3K	Cardiovascular Disease Cancer
α-Linolenic acid sodium (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid sodium can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid sodium possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-W004283R

Pentadecanoic acid (Standard)	Reference Standards Endogenous Metabolite JAK STAT PPAR p38 MAPK JNK ERK Caspase Apoptosis	Metabolic Disease Cancer
α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-122464S1

Jasmonic acid-d5	Isotope-Labeled Compounds	Others
Jasmonic acid-d₅ is deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.

HY-N0728S2

α-Linolenic acid-d14	Isotope-Labeled Compounds PI3K Akt	Cardiovascular Disease Cancer
α-Linolenic acid-d₁₄ is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-115707

1-Palmitoyl-3-Linolenoyl-rac-glycerol 16:0/0:0/18:3-DG; DG(16:0/0:0/18:3); 1-Palmitin-3-Linolenin	Others	Others
1-Palmitoyl-3-Linolenoyl-rac-glycerol (16:0/0:0/18:3-DG) is a diacylglycerol containing palmitic acid (HY-N0830) and α-linolenic acid (HY-N0728) at the sn-1 and sn-3 positions, respectively. It has been found in the peel and pulp of unripe Dwarf Cavendish bananas.

HY-172579

(±)15,16-DiHODE	Drug Derivative	Metabolic Disease
(±)15,16-DiHODE is a derived oxylipin of α-Linolenic acid (HY-N0728) .

HY-122464B

7-epi Jasmonic acid 2-iso Jasmonic acid; 7-iso Jasmonic acid	Herbicide	Others
7-epi Jasmonic acid is the isomer of (±)-Jasmonic acid (HY-122464). (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.

HY-W778471

rac-1-Linoleoyl-3-linolenoyl-propanetriol DG(18:2/0:0/18:3); 1-Linolein-3-α-Linolenin; 1-Linolein-3-Linolenin	Endogenous Metabolite	Metabolic Disease
1-Linoleoyl-3-α-linolenoyl-rac-glycerol is a diacylglycerol that contains linoleic acid (HY-N0729) at the sn-1 position and α-linolenic acid (HY-N0728) at the sn-3 position. It has been found in olive oil subjected to lipase-catalyzed glycerolysis with immobilized lipase B from C. antarctica.

HY-131310

9(S)-HpOTrE	Endogenous Metabolite	Metabolic Disease
9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions. 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid.The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to occur via formation of an unstable epoxide.

HY-180676

*(R)-2-Hydroperoxy-α-linolenic* acid**	Nucleoside Antimetabolite/Analog	Metabolic Disease
(R)-2-Hydroperoxy-α-linolenic acid is a nucleoside metabolite.

HY-180675

*(R)-2-Hydroxy-α-linolenic* acid**	Nucleoside Antimetabolite/Analog	Metabolic Disease
(R)-2-Hydroxy-α-linolenic acid is a nucleoside metabolite.

HY-N19627

3'-O-Methyl-(-)-epicatechin gallate 3′-M-ECG	Drug Derivative	Inflammation/Immunology
3'-O-Methyl-(-)-epicatechin gallate (3′-M-ECG) is a methylated Catechin (HY-N0898) derivative and is an antioxidant agent. 3'-O-Methyl-(-)-epicatechin gallate reduces oxygen consumption and prevents decreases in linoleic and α-linolenic acids to protect canola oil from lipid oxidation when heated .

HY-N17745

(-)-EGCG-3'-O-Me		Others
(-)-EGCG-3'-O-Me is a catechin derivative (HY-N0898). (-)-EGCG-3'-O-Me inhibits lipid oxidation in rapeseed oil by reducing oxygen consumption and protecting linoleic acid and α-linolenic acid from degradation during heating. The antioxidant activity of (-)-EGCG-3'-O-Me in heated rapeseed oil is lower than that of its non-methylated precursor, (-)-epigallocatechin (EGCG) (HY-N0225) .

HY-23201

A1-Phytoprostane-I Phytoprostane A1; PPA1	Others	Metabolic Disease
A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants.

HY-158964

1-Palmitoyl-2-oleoyl-3-linolenoyl-rac-glycerol 1-Palmitin-2-olein-3-linolenin; TG(16:0/18:1/18:3)	Biochemical Assay Reagents	Metabolic Disease
1-Palmitoyl-2-oleoyl-3-linolenoyl-rac-glycerol (1-Palmitin-2-olein-3-linolenin) is a triacylglycerol that contains Palmitic acid (HY-N0830), Oleic acid (HY-N1446), and α-Linolenic acid (HY-N0728).

Cat. No.	Product Name	Target	Research Area

HY-145512

N-(α-Linolenoyl) tyrosine NLT	Dopamine Receptor	Neurological Disease
N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0728

α-Linolenic acid Maximum Cited Publications 11 Publications Verification ALA free base; C18:3 (9Z,12Z,15Z) free base; C18:3 n-3 free base	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Labiatae Ulex europaeus L. Disease markers Plants Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Environmental Pollutants Akt PI3K
α-Linolenic acid (ALA (free base); C18:3 (9Z,12Z,15Z) (free base); C18:3 n-3 (free base)) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	Structural Classification Punica granatum L. Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Punicaceae Plants Disease Research Fields Source Classification	TNF Receptor GLUT Proteasome Tau Protein PKC
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-N0728R

α-Linolenic acid (Standard) Maximum Cited Publications 11 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Ulex europaeus L. Plants Endogenous metabolite Microorganisms Labiatae Disease markers Disease Research Fields Cardiovascular System Disorder Source Classification	Reference Standards PI3K Akt
α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Lipoxygenase
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-W004283R

Pentadecanoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite JAK STAT PPAR p38 MAPK JNK ERK Caspase Apoptosis
α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-180676

*(R)-2-Hydroperoxy-α-linolenic* acid**	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
(R)-2-Hydroperoxy-α-linolenic acid is a nucleoside metabolite.

HY-180675

*(R)-2-Hydroxy-α-linolenic* acid**	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
(R)-2-Hydroxy-α-linolenic acid is a nucleoside metabolite.

HY-N19627

3'-O-Methyl-(-)-epicatechin gallate 3′-M-ECG	Structural Classification Flavonoids Camellia sinensis (L.) O. Ktze. Plants Other Flavonoids Source Classification Theaceae	Drug Derivative
3'-O-Methyl-(-)-epicatechin gallate (3′-M-ECG) is a methylated Catechin (HY-N0898) derivative and is an antioxidant agent. 3'-O-Methyl-(-)-epicatechin gallate reduces oxygen consumption and prevents decreases in linoleic and α-linolenic acids to protect canola oil from lipid oxidation when heated .

HY-N17745

(-)-EGCG-3'-O-Me	Brassica rapa var. oleifera de Candolle Structural Classification Phenols Polyphenols Plants Brassicaceae Source Classification
(-)-EGCG-3'-O-Me is a catechin derivative (HY-N0898). (-)-EGCG-3'-O-Me inhibits lipid oxidation in rapeseed oil by reducing oxygen consumption and protecting linoleic acid and α-linolenic acid from degradation during heating. The antioxidant activity of (-)-EGCG-3'-O-Me in heated rapeseed oil is lower than that of its non-methylated precursor, (-)-epigallocatechin (EGCG) (HY-N0225) .

Cat. No.	Product Name	Chemical Structure

HY-N0728S3

α-Linolenic acid-13C18
α-Linolenic acid- ¹³C₁₈ is the ¹³C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

α-Linolenic acid-13C18

α-Linolenic acid- ¹³C₁₈ is the ¹³C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-N0728S

α-Linolenic acid-d5
α-Linolenic acid-d₅ is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-122464S2

(±)-Jasmonic acid-d5
(±)-Jasmonic acid-d₅ is the deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.

HY-N0728S2

α-Linolenic acid-d14
α-Linolenic acid-d₁₄ is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

α-Linolenic acid-d14

α-Linolenic acid-d₁₄ is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

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α-Linolenic acid

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