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Isoforms Recommended:	α adrenergic receptor

Results for "

α1A-Adrenergic receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (9) Adenosine Receptor (2) Adrenergic Receptor (38) Akt (2) Apoptosis (9) Autophagy (5) Bacterial (2) Bcl-2 Family (2) Beta-secretase (2) Calcium Channel (1) Dopamine Receptor (5) Drug Isomer (1) Drug Metabolite (1) GABA Receptor (2) Histamine Receptor (5) Isotope-Labeled Compounds (2) mTOR (2) PI3K (2) PROTACs (1) Reference Standards (7)
By Research Areas:	Cancer (10) Cardiovascular Disease (14) Endocrinology (16) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (13)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-10122

Silodosin 5 Publications Verification KAD 3213; KMD 3213	Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-A0077

Perphenazine 3 Publications Verification	Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to **Alpha-1A adrenergic receptor**. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Bcl-2 Family Apoptosis mTOR GABA Receptor PI3K Adrenergic Receptor Beta-secretase Akt	Cancer
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and *α1D-*adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine is applicable to research related to leukemia, ovarian cancer, and colorectal cancer .

HY-B1435

Moxisylyte hydrochloride Thymoxamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) hydrochloride is a selective **α₁A-adrenergic receptor** antagonist. Moxisylyte hydrochloride competitively antagonizes the activation mediated by norepinephrine. Moxisylyte hydrochloride relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte hydrochloride is applicable to research related to erectile dysfunction and multiple system atrophy .

HY-101300

Cirazoline hydrochloride LD 3098 hydrochloride	Adenosine Receptor	Neurological Disease
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (K_i=120 nM) and only a partial agonist at α1B-AR (K_i= 960 nM) and α1D-AR (K_i=660 nM) .

HY-101385

L-765314 2 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology
L-765314 is a potent and selective **α1b adrenergic receptor antagonist with K_i*s of 5.4 nM and 2.0 nM for rat and human α1b adrenergic* receptor, respectively.

HY-117071

Dabuzalgron Ro 115-1240	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Dabuzalgron (Ro 115-1240) is an orally active and selective **α-1A adrenergic receptor** agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function .

HY-101366

A-61603	Adrenergic Receptor	Endocrinology
A-61603 is a selective **α₁A/α₁a-adrenergic receptor agonist with K_i of 8.89 nM for rat submaxillary gland α1A, K_i of 30.5 nM for cloned bovine α1a. A-61603 potentiates Ca ²⁺ transients with EC₅₀** of 6.9 nM. A-61603 stimulates phosphoinositide hydrolysis, induces contractile responses in vas deferens, prostate strips, and spleen strips, and exhibits low activity in aortic rings. A-61603 can be used for research on adrenergic function .

HY-147100

α1A-AR Degrader 9c	PROTACs Adrenergic Receptor	Cancer
α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC₅₀ of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC₅₀ of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research .

HY-106954

Upidosin Rec 15/2739; Recordati 15/2739; SB 216469	Adrenergic Receptor	Inflammation/Immunology
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a K_b value of 2-3 nM higher than in ear artery and aorta with a K_b value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

HY-101755

Tedatioxetine hydrobromide Lu AA24530 hydrobromide	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT_2A, 5-HT_2C, 5-HT₃ and **α_1A-adrenergic receptor** antagonist . ,

HY-A0077S1

Perphenazine-d4	5-HT Receptor Adrenergic Receptor Apoptosis Autophagy Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Perphenazine-d₄ is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human **α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor** and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel **α₁-Adrenergic Receptor** subtype-selective drugs .

HY-W103372

Vasorelaxant agent-2	Adrenergic Receptor	Cardiovascular Disease
Vasorelaxant agent-2 (Compound 8h) targets **α1A-adrenergic receptor with an affinity of pD2=5.4. Vasorelaxant agent-2 exhibits vasodilator activity in rats aortic rings with an EC₅₀** of 0.79 μM .

HY-123044

Tedatioxetine Lu AA24530	5-HT Receptor Adrenergic Receptor	Neurological Disease
Tedatioxetine (Lu AA24530) acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT_2A, 5-HT_2C, 5-HT₃ and **α_1A-adrenergic receptor** antagonist .

HY-120473

TAK-259	Adrenergic Receptor	Metabolic Disease
TAK-259 is an orally active α1D-adrenergic *receptor* antagonist with a K_i value of 1.1 nM for human α1D-adrenergic receptors. TAK-259 can inhibit the contraction of isolated bladder strips in rats with bladder outlet obstruction, reduce non-voiding bladder contractions, and improve urinary frequency symptoms. TAK-259 can be used in research related to overactive bladder .

HY-A0077A

Perphenazine dihydrochloride	Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to **Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer cell proliferation, and induces apoptosis**. Perphenazine dihydrochloride can be used in the research of mental disease, cancer, inflammation .

HY-125641

AL-34662	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease
AL-34662 is a selective 5-HT2A receptoragonist (IC₅₀: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak *α-1D adrenergic* agonist activity (EC₅₀:0.4 μM). AL-34662 is an ocular hypotensive agent .

HY-145480

Silodosin Glucuronide sodium Silodosin β-D-glucuronide sodium	Drug Metabolite	Others
Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for **α1A-adrenergic receptor (α1A-AR) with K_i** of 0.036 nM .

HY-B1435A

Moxisylyte Thymoxamine	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) is a selective **α₁A-adrenergic receptor** antagonist. Moxisylyte competitively antagonizes the activation mediated by norepinephrine. Moxisylyte relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte is applicable to research related to erectile dysfunction and multiple system atrophy .

HY-U00237B

L-771688 hydrochloride	Adrenergic Receptor	Others
L-771688 hydrochloride is a potent and highly selective α1A-adrenoceptor antagonist (Kd=43-90 pM). L-771688 hydrochloride is effective against cloned human, rat and dog α1A-adrenergic receptors. L-771688 exhibits high affinity (Ki ≤ 1 nM) and over 500-fold selectivity over the α1B and α1D isoforms. L-771688 potently antagonizes norepinephrine-induced responses at these receptors. Inhibits contractions induced by phenylephrine or A-61603 in rat, dog, human and monkey models .

HY-10122S

Silodosin-d4	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology Cancer
Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-10122R

Silodosin (Standard) KAD 3213 (Standard); KMD 3213 (Standard)	Reference Standards Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (Standard) is the analytical standard of Silodosin. This product is intended for research and analytical applications. Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-103202

SNAP5089 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
SNAP5089 (hydrochloride) is a selective **α1A adrenergic receptor** antagonist. SNAP5089 (hydrochloride) can be used in the research of hypertension and benign prostatic hyperplasia .

HY-101390

(+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride	Calcium Channel Adrenergic Receptor	Cardiovascular Disease
(+)-Niguldipine hydrochloride is a 1,4-DHP receptor ligand associated with L-type Ca ²⁺ channels (with K_i values of 85 pmol/L in guinea pig skeletal muscle, 140 pmol/L in brain, and 45 pmol/L in heart) as well as an **α₁-adrenergic receptor ligand (with a K_i value of 78 nmol/L). (+)-Niguldipine hydrochloride shows much higher binding selectivity for α_1α-**adrenergic receptors than for *α_1B-*adrenergic receptors. (+)-Niguldipine hydrochloride can be used in studies related to hypertension .

HY-118039

Abanoquil methylsulfate UK-52046 methylsulfate	Adrenergic Receptor	Cardiovascular Disease
Abanoquil methylsulfate (UK-52046 methylsulfate) is an alpha-1 family adrenergic *receptor* antagonist. Abanoquil methylsulfate can be used in research on cardiovascular diseases such as arrhythmias and erectile dysfunction .

HY-117071A

Dabuzalgron hydrochloride Ro 115-1240 hydrochloride	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology
Dabuzalgron (Ro 115-1240) hydrochloride is an orally active and selective **α-1A adrenergic receptor** agonist for the treatment of urinary incontinence. Dabuzalgron hydrochloride protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function .

HY-111188

A55453	Adrenergic Receptor	Others
A55453 is a prazosin analogue and a potent *α1-adrenergic* antagonist. ^125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe .

HY-133214

Cyclazosin hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Cyclazosin hydrochloride is an α_1B-adrenergic *receptor* antagonist. Cyclazosin hydrochloride has high specificity for α-adrenergic receptors, with pK_i values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la) and OflB (alb) adrenergic receptors, respectively. However, Cyclazosin hydrochloride cannot distinguish between cloned alb and alo adrenergic receptors, which have pK_i values of 9.23 and 9.28, respectively .

HY-B0661C

Tamsolusin hydrochloride YM12617 hydrochloride; LY253351 hydrochloride	Adrenergic Receptor	Endocrinology
Tamsolusin (YM12617) hydrochloride is a highly selective alpha-1A adrenergic receptor antagonist used in the treatment of benign prostatic hypertrophy, demonstrating effective biological activity in alleviating associated symptoms. Tamsolusin hydrochloride can also be quantified using a validated spectrofluorimetric method, showcasing its potential for routine quality control analysis in pharmaceutical formulations.

HY-A0077S2

Perphenazine-d6 fumarate	Isotope-Labeled Compounds Histamine Receptor Autophagy Adrenergic Receptor Apoptosis Dopamine Receptor 5-HT Receptor	Cancer
Perphenazine-d6 (fumarate) is a deuterated labeled Perphenazine . Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to **Alpha-1A adrenergic receptor**. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .

HY-183177

Zolertine	Adrenergic Receptor	Cardiovascular Disease
Zolertine is an α-adrenergic receptor antagonist, with a pK_i of 6.35 for rabbit α₁A-adrenergic receptor and a pK_i of 6.81 for rat α₁B-adrenergic receptor. Zolertine competitively blocks α₁D-adrenergic receptor-mediated vasoconstriction and α₁A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension .

HY-A0077R

Perphenazine (Standard)	Reference Standards Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Perphenazine (Standard) is the analytical standard of Perphenazine. This product is intended for research and analytical applications. Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to **Alpha-1A adrenergic receptor**. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .

HY-101300R

Cirazoline hydrochloride (Standard) LD 3098 hydrochloride (Standard)	Reference Standards Adenosine Receptor	Neurological Disease
Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) .

HY-10122A

(Rac)-Silodosin (Rac)-KAD 3213; (Rac)-KMD 3213	Adrenergic Receptor	Endocrinology
(Rac)-Silodosin ((Rac)-KAD 3213) is the racemate of Silodosin (HY-10122). Silodosin is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker .

HY-B1435R

Moxisylyte hydrochloride (Standard) Thymoxamine hydrochloride (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease Neurological Disease Metabolic Disease
Moxisylyte (Thymoxamine) hydrochloride Standard is the analytical standard of Moxisylyte hydrochloride (HY-B1435). This product is intended for research and analytical applications. Moxisylyte (Thymoxamine) hydrochloride is a selective **α₁A-adrenergic receptor** antagonist. Moxisylyte hydrochloride competitively antagonizes the activation mediated by norepinephrine. Moxisylyte hydrochloride relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte hydrochloride is applicable to research related to erectile dysfunction and multiple system atrophy.

HY-101755R

Tedatioxetine hydrobromide (Standard) Lu AA24530 hydrobromide (Standard)	Reference Standards 5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Tedatioxetine hydrobromide (Standard) (Lu AA24530 hydrobromide (Standard)) is the analytical standard of Tedatioxetine hydrobromide (HY-101755). This product is intended for research and analytical applications. Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist . ,

HY-101385R

L-765314 (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease Endocrinology
L-765314 (Standard) is the analytical standard of L-765314 (HY-101385). This product is intended for research and analytical applications. L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.

HY-120473A

TAK-259 hydrochloride	Adrenergic Receptor	Metabolic Disease
TAK-259 hydrochloride is an orally active α1D-adrenergic *receptor* antagonist with a K_i value of 1.1 nM for human α1D-adrenergic receptors. TAK-259 hydrochloride can inhibit the contraction of isolated bladder strips in rats with bladder outlet obstruction, reduce non-voiding bladder contractions, and improve urinary frequency symptoms. TAK-259 hydrochloride can be used in research related to overactive bladder .

HY-W783844

(R)-Nantenine	Drug Isomer	Neurological Disease
(R)-Nantenine ((R)-(-)-nantenine) is the levorotatory isomer of Nantenine (HY-N9141). (R)-Nantenine has high affinity and selectivity for the **α1A adrenergic receptor**. (R)-Nantenine can block the behavioral suppression induced by MDMA. (R)-Nantenine is mainly used for the research related to diseases caused by MDMA abuse .

HY-N1255A

Scoulerine hydrochloride (-)-Scoulerine hydrochloride; Discretamine hydrochloride	Apoptosis PI3K Akt mTOR Adrenergic Receptor GABA Receptor Beta-secretase Bcl-2 Family	Cancer
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine hydrochloride mainly targets the PI3K/Akt/mTOR signaling axis and *α1D-*adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine hydrochloride effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine hydrochloride also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine hydrochloride is applicable to research related to leukemia, ovarian cancer, and colorectal cancer .

HY-106954R

Upidosin (Standard) Rec 15/2739 (Standard); Recordati 15/2739 (Standard); SB 216469 (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology
Upidosin (Standard) (Rec 15/2739 (Standard)) is the analytical standard of Upidosin (HY-106954). This product is intended for research and analytical applications. Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

Cat. No.	상품명	Target	Research Area

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human **α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor** and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel **α₁-Adrenergic Receptor** subtype-selective drugs .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Alkaloids Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Bcl-2 Family Apoptosis mTOR GABA Receptor PI3K Adrenergic Receptor Beta-secretase Akt
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and *α1D-*adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine is applicable to research related to leukemia, ovarian cancer, and colorectal cancer .

HY-N1255A

Scoulerine hydrochloride (-)-Scoulerine hydrochloride; Discretamine hydrochloride	Structural Classification Alkaloids Phenols Polyphenols Umbelliferae Plants Isoquinoline Alkaloids Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Apoptosis PI3K Akt mTOR Adrenergic Receptor GABA Receptor Beta-secretase Bcl-2 Family
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine hydrochloride mainly targets the PI3K/Akt/mTOR signaling axis and *α1D-*adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine hydrochloride effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine hydrochloride also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine hydrochloride is applicable to research related to leukemia, ovarian cancer, and colorectal cancer .

Cat. No.	상품명	Chemical Structure

HY-A0077S1

Perphenazine-d4
Perphenazine-d₄ is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-10122S

Silodosin-d4

Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH .

HY-A0077S2

Perphenazine-d6 fumarate

Perphenazine-d6 (fumarate) is a deuterated labeled Perphenazine . Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (3) WB (3) FC (2)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P82314

	alpha 1a Adrenergic Receptor Antibody (YA2059) ADRA1A; ADRA1C; Alpha-1A Adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C Adrenergic receptor; Alpha-Adrenergic receptor 1c	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	alpha 1a Adrenergic Receptor Antibody (YA2059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1a Adrenergic Receptor.

HY-P82314A

	alpha 1a Adrenergic Receptor Antibody (YA2059)(PBS only) ADRA1A; ADRA1C; Alpha-1A Adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C Adrenergic receptor; Alpha-Adrenergic receptor 1c	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	alpha 1a Adrenergic Receptor Antibody (YA2059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1a Adrenergic Receptor.

HY-P811140

	Alpha-1D Adrenergic Receptor Antibody Adra1a, Gpcr8, Adra1d, Alpha-1D Adrenergic receptor, Alpha-1A Adrenergic receptor, Alpha-1D adrenoreceptor, Alpha-1D adrenoceptor	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Alpha-1D Adrenergic Receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Alpha-1D Adrenergic Receptor.

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