AL-34662
Based on 1 Customer Validation
AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 210580-75-9
- Formula: C10H13N3O
- Molecular Weight:191.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT2A Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1460 nM
Compound: 9
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Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production
Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production
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[PMID: 16392816] |
| HT-29 | EC50 |
2600 nM
Compound: 9
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Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay
Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assay
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[PMID: 16392816] |
| HT-29 | EC50 |
>10000 nM
Compound: 9
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Activity at adrenergic alpha-2A receptor expressed in human clonic adenocarcinoma HT29 cell by adenylyl cyclase assay
Activity at adrenergic alpha-2A receptor expressed in human clonic adenocarcinoma HT29 cell by adenylyl cyclase assay
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[PMID: 16392816] |
Chemical Information
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CAS No. 210580-75-9
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Appearance Solid
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Molecular Weight 191.23
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Formula C10H13N3O
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Color White to off-white
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SMILES
OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (326.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13. [Content Brief]
[2]. Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174(19):3370-3381. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2293 mL | 26.1465 mL | 52.2931 mL | 130.7326 mL |
| 5 mM | 1.0459 mL | 5.2293 mL | 10.4586 mL | 26.1465 mL | |
| 10 mM | 0.5229 mL | 2.6147 mL | 5.2293 mL | 13.0733 mL | |
| 15 mM | 0.3486 mL | 1.7431 mL | 3.4862 mL | 8.7155 mL | |
| 20 mM | 0.2615 mL | 1.3073 mL | 2.6147 mL | 6.5366 mL | |
| 25 mM | 0.2092 mL | 1.0459 mL | 2.0917 mL | 5.2293 mL | |
| 30 mM | 0.1743 mL | 0.8716 mL | 1.7431 mL | 4.3578 mL | |
| 40 mM | 0.1307 mL | 0.6537 mL | 1.3073 mL | 3.2683 mL | |
| 50 mM | 0.1046 mL | 0.5229 mL | 1.0459 mL | 2.6147 mL | |
| 60 mM | 0.0872 mL | 0.4358 mL | 0.8716 mL | 2.1789 mL | |
| 80 mM | 0.0654 mL | 0.3268 mL | 0.6537 mL | 1.6342 mL | |
| 100 mM | 0.0523 mL | 0.2615 mL | 0.5229 mL | 1.3073 mL |
AL-34662 Related Classifications
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