2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. AL-34662

AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent.

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AL-34662 Chemical Structure

AL-34662 Chemical Structure

CAS No. : 210580-75-9

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5 mg USD 122 In-stock
10 mg USD 195 In-stock
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Based on 1 publication(s) in Google Scholar

AL-34662 Related Antibodies

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Description

AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2].

IC50 & Target

0.77 nM and 1.5 nM for rat and human 5-HT2 receptor[1]
Molecular Weight

191.23

Formula

C10H13N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (326.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2293 mL 26.1465 mL 52.2930 mL
5 mM 1.0459 mL 5.2293 mL 10.4586 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2293 mL 26.1465 mL 52.2931 mL 130.7326 mL
5 mM 1.0459 mL 5.2293 mL 10.4586 mL 26.1465 mL
10 mM 0.5229 mL 2.6147 mL 5.2293 mL 13.0733 mL
15 mM 0.3486 mL 1.7431 mL 3.4862 mL 8.7155 mL
20 mM 0.2615 mL 1.3073 mL 2.6147 mL 6.5366 mL
25 mM 0.2092 mL 1.0459 mL 2.0917 mL 5.2293 mL
30 mM 0.1743 mL 0.8716 mL 1.7431 mL 4.3578 mL
40 mM 0.1307 mL 0.6537 mL 1.3073 mL 3.2683 mL
50 mM 0.1046 mL 0.5229 mL 1.0459 mL 2.6147 mL
60 mM 0.0872 mL 0.4358 mL 0.8716 mL 2.1789 mL
80 mM 0.0654 mL 0.3268 mL 0.6537 mL 1.6342 mL
100 mM 0.0523 mL 0.2615 mL 0.5229 mL 1.3073 mL
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AL-34662 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-34662210580-75-9AL34662AL 34662Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorocular hypotensiveIOP5-HT2 Receptor AgonistInhibitorinhibitorinhibit

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