210580-75-9
210580-75-9
Chemical Structure
AL-34662
- CAS No.: 210580-75-9
- Formula:C10H13N3O
- Molecular Weight:191.23
IUPAC Name: (S)-1-(2-aminopropyl)-1H-indazol-6-ol
InChIKey: WBYHTZYHAFNBKW-ZETCQYMHSA-N
SMILES: OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C
Biological Activity: AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AL-34662 | 99.20% | AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent. | ||||||||||||||||||||
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References
- [1]. Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13. [Content Brief]
- [2]. Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174(19):3370-3381. [Content Brief]
Keywords
