210580-75-9
210580-75-9
Chemical Structure
AL-34662
- CAS No.: 210580-75-9
- Formula:C10H13N3O
- Molecular Weight:191.23
IUPAC Name: (S)-1-(2-aminopropyl)-1H-indazol-6-ol
InChIKey: WBYHTZYHAFNBKW-ZETCQYMHSA-N
SMILES: OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C
Biological Activity: AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
AL-34662 | 99.20% | AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.75
HY-145463α-Methylserotonin -
Similarity Score 0.75
HY-123838Ro60-0175 -
Similarity Score 0.75
HY-690241-Methyl-1H-indazol-5-amine -
Similarity Score 0.73
HY-107354Gepefrine -
Similarity Score 0.73
HY-W3288823-(2-Aminopropyl)phenol -
Similarity Score 0.72
HY-590595-(2-Aminopropyl)indole -
Similarity Score 0.72
HY-1720286-(2-Aminopropyl)indole -
Similarity Score 0.72
HY-W0011196-Hydroxyindazole -
Similarity Score 0.72
HY-691661H-Indazol-5-ol -
Explore the MedChemAI to find more analogs
References
- [1]. Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13. [Content Brief]
- [2]. Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174(19):3370-3381. [Content Brief]
