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Results for "

Aβ-IN-10

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

2

Peptides

4

Natural
Products

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15507
    VGX-1027
    1 Publications Verification

    GIT 27

    		 Interleukin Related TNF Receptor Metabolic Disease Inflammation/Immunology
    VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .
    VGX-1027
  • HY-155534
    17β-HSD10-IN-1

    		17β-HSD Others
    17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .
    17β-HSD10-IN-1
  • HY-158036
    PROTAC STING Degrader-2

    		PROTACs STING IKK IFNAR CXCR Inflammation/Immunology
    PROTAC STING Degrader-2 is a STING PROTAC degrader with a DC50 of 0.53 μM. PROTAC STING Degrader-2 reduces the phosphorylation levels of TBK1 and IRF3. PROTAC STING Degrader-2 decreases the mRNA expression levels of IFN-β, CXCL10 and TNF-α, and blocks luciferase secretion. PROTAC STING Degrader-2 can be used in the research of autoimmune diseases .
    PROTAC STING Degrader-2
  • HY-N12110
    SMU-CX1

    		Toll-like Receptor (TLR) SARS-CoV Infection
    SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .
    SMU-CX1
  • HY-169268
    Aβ-IN-10

    		Amyloid-β Neurological Disease
    Aβ-IN-10 (Compound Alz -5) is a bifunctional copper chelator and an inhibitor for beta-amyloid (Aβ), that interacts with Aβ aggregates and reduces the neurotoxicity. Aβ-IN-10 exhibits antioxidant efficacy, reveals moderate cytotoxicity with the presence of CuCl2 in SH-SY5Y and HepG2 with IC50 of 65.5, 31.2 μM. Aβ-IN-10 reduces the increase of cell stiffness caused by Aβ .
    Aβ-IN-10
  • HY-147134
    GSK-3β inhibitor 10

    		GSK-3 Neurological Disease
    GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease .
    GSK-3β inhibitor 10
  • HY-N15681
    β-Apo-10'-carotenal

    10'-Apo-β-carotenal

    		 Drug Metabolite Others
    β-Apo-10'-carotenal is a degradation product of β,β-carotene. β-Apo-10'-carotenal can be used in flavor research .
    β-Apo-10'-carotenal
  • HY-175676
    THR-β agonist 10

    		Thyroid Hormone Receptor Metabolic Disease Inflammation/Immunology
    THR-β agonist 10 is an orally active and selective THR-β agonist, with an EC50 of 11 nM. THR-β agonist 10 significantly reduces ALT (Alanine Aminotransferase), TC (Total Cholesterol), and LDL-C (Low-Density Lipoprotein Cholesterol) levels, and improves steatosis, ballooning, inflammation and fibrosis in the metabolic dysfunction-associated steatohepatitis (MASH) mouse model. THR-β agonist 10 can be used for the study of MASH .
    THR-β agonist 10
  • HY-P1053
    β-Amyloid (10-20)

    		Amyloid-β Neurological Disease
    β-Amyloid (10-20) is a fragment of Amyloid-β peptide and maybe used in the research of neurological disease .
    β-Amyloid (10-20)
  • HY-157935
    17β-HSD10-IN-3

    		17β-HSD Neurological Disease
    17β-HSD10-IN-3 (compound 23) is a 17β-HSD10 inhibitor with the IC50 of 5.59 μM. 17β-HSD10-IN-3 shows no cell cytotoxicity toward the HEK-293 cell line up to 20 μM .
    17β-HSD10-IN-3
  • HY-155535
    17β-HSD10-IN-2

    		17β-HSD Neurological Disease
    17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor，targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10)，a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer .
    17β-HSD10-IN-2
  • HY-P1567
    β-Amyloid (10-35), amide

    		Amyloid-β Neurological Disease
    β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
    β-Amyloid (10-35), amide
  • HY-117461
    Y 25510

    		Drug Derivative Interleukin Related Inflammation/Immunology
    Y 25510 is a 1H-pyrazolo[3,4-b]pyridine-1-acetic acid derivative. Y 25510 stimulates production of cytokines (IL-1α, IL-1β, IL-10 and IL-6) .
    Y 25510
  • HY-176270
    ESC1002755

    		17β-HSD Neurological Disease Cancer
    ESC1002755 is a 17β-HSD10 inhibitor with an IC50 of 19 nM. ESC1002755 has significant enzyme specificity with non-/uncompetitive inhibition against the cofactor NADH. ESC1002755 shows minimal cytotoxicity towards the HEK293 at 50 μM. ESC1002755 is promising for Alzheimer’s disease and hormone-dependent cancers (such as prostate, bone and colorectal cancer) research .
    ESC1002755
  • HY-174657
    Human IFNLR1 mRNA

    		mRNA Inflammation/Immunology
    Human IFNLR1 mRNA encodes the human interferon lambda receptor 1 (IFNLR1) protein, a member of the class II cytokine receptor family. IFNLR1, interleukine 10 receptor and beta (IL10RB) form a receptor complex which has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29).
    Human IFNLR1 mRNA
  • HY-117921
    DA-E 5090

    		Interleukin Related Inflammation/Immunology
    DA-E 5090 is an orally effective inhibitor of IL-1 production that can be converted into a pharmacologically active deacetylated form (DA-E5090) in vivo. In this study, the effects of DA-E5090 on IL-1 production in vitro were examined by LPS-stimulated human monocytes. The results showed that DA-E5090 could dose-dependently inhibit the production of IL-1α and IL-1β (1-10 μM) by LPS-stimulated human monocytes, as determined by LAF assay and ELISA. Northern blotting analysis showed that DA-E5090 inhibited the transcription of IL-1α and IL-1β mRNA.
    DA-E 5090
  • HY-155232
    PI3Kδ-IN-16

    		PI3K Apoptosis Cancer
    PI3Kδ-IN-16 is a potent and selective PI3Kδ inhibitor with an IC50 value of 0.9 nM. PI3Kδ-IN-16 has a strong anti-proliferative effect on SU-DHL-6 cells, causing cell cycle arrest and inducing apoptosis. PI3Kδ-IN-16 tightly bins to PI3Kδ protein with a planar-shaped conformation. The kinase activity of PI3Kδ-IN-16 which is ~378-fold over PI3Kα, 412-fold over PI3Kβ, and 10-fold over PI3Kγ. PI3Kδ-IN-16 can be used for the study of hematologic malignancies .
    PI3Kδ-IN-16
  • HY-183999
    17β-HSD10-IN-5

    		17β-HSD Neurological Disease
    17β-HSD10-IN-5 is a potent 17β-HSD10 inhibitor with an IC50 of 0.31 μM. 17β-HSD10-IN-5 can be used for the research of alzheimer’s disease .
    17β-HSD10-IN-5
  • HY-182028
    17β-HSD10-IN-4

    		17β-HSD Reactive Oxygen Species (ROS) Tau Protein Amyloid-β CDK Mitochondrial Metabolism Neurological Disease
    17β-HSD10-IN-4 is a selective brain-penetrant 17β-HSD10 inhibitor with an IC50 of 6.33 μM. 17β-HSD10-IN-4 forms key interactions with the 17β-HSD10 catalytic triad to functionally inhibit the enzyme, without altering its protein levels. 17β-HSD10-IN-4 restores mitochondrial function, reduces ROS levels, increases ATP production, and suppresses cytochrome c release. 17β-HSD10-IN-4 attenuates CDK5/p25 activation, reduces Tau hyperphosphorylation, Aβ plaque load and restores brain-derived neurotrophic factor levels. 17β-HSD10-IN-4 improves cognitive function.17β-HSD10-IN-4 can be used for the research of Alzheimer's disease .
    17β-HSD10-IN-4
  • HY-183280
    17β-HSD10/CDK5-IN-1

    		17β-HSD CDK Amyloid-β Tau Protein Reactive Oxygen Species (ROS) Neurological Disease
    17β-HSD10/CDK5-IN-1 is a poent dual 17β-HSD10 and CDK5 inhibitor with IC50s of 2.44 and 0.26 μM for 17β-HSD10 and CDK5, respectively. 17β-HSD10/CDK5-IN-1 reduces ROS accumulation, attenuates pathological Tau phosphorylation, reduces Aβ plaque deposition, and ameliorates cognitive deficits in Alzheimer's mice. 17β-HSD10/CDK5-IN-1 can be used for the research of Alzheimer's disease .
    17β-HSD10/CDK5-IN-1
  • HY-E71292
    β-Eudesmol synthase

    		Biochemical Assay Reagents Others
    β-Eudesmol synthase (EC 4.2.3.68) gives β-Eudesmol, 10-epi-γ-eudesmol, α-eudesmol, and aristolene.
    β-Eudesmol synthase
  • HY-E71226
    α-Eudesmol synthase

    		Biochemical Assay Reagents Others
    α-Eudesmol synthase (EC 4.2.3.85) from ginger (Zingiber zerumbet) gives β-eudesmol, 10-epi-γ-Eudesmol, α-Eudesmol, and aristolene.
    α-Eudesmol synthase
  • HY-E71176
    10-epi-γ-Eudesmol synthase

    		Biochemical Assay Reagents Others
    10-epi-γ-Eudesmol synthase (EC 4.2.3.84) from ginger (Zingiber zerumbet) gives β-eudesmol, 10-epi-γ-Eudesmol, α-Eudesmol, and aristolene.
    10-epi-γ-Eudesmol synthase
  • HY-181484
    STING agonist-50

    		STING IKK IFNAR Interleukin Related CXCR Cancer
    STING agonist-50 is an orally active STING agonist with an IC50 of 3.457 μM. STING agonist-50 activates the STING signaling pathway and promotes the phosphorylation of downstream TBK1 and IRF3. STING agonist-50 induces the expression of IFN-β, CXCL10 and IL-6. STING agonist-50 inhibits tumor growth in syngeneic mouse models. STING agonist-50 can be used for the research of colorectal cancer .
    STING agonist-50

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