Interferon & Receptors

Interferons (IFNs) are a family of antiviral cytokines that are secreted by host cells in response to viral and microbial infections. The functions of IFNs are represented by three major biological activities: antiviral activity, antitumor activity and immunoregulatory activity. Based on their receptor specificity and sequence homology, the mammalian interferons are divided into three types based on amino acid sequence homology and the receptors they use: type I IFN (IFN-α, β, ε, κ, ω, δ, τ, ζ), type II IFN (IFN-γ), and type III IFN (IFN-λ1, λ2, λ3, λ4). IFN signaling is initiated by binding to distinct heterodimeric receptor complexes on the cell membrane.

Interferon & Receptors (12):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-174667

Human IFNA4 mRNA
Human IFNA4 mRNA encodes the human interferon alpha 4 (IFNA4) protein, which may have antiviral activities.

HY-174666

Human IFNAR1 mRNA
Human IFNAR1 mRNA encodes the human interferon alpha and beta receptor subunit 1 (IFNAR1) protein, a protein that belongs to the type II cytokine receptor family and functions as an antiviral factor.

HY-174665

Human IFNAR2 mRNA
Human IFNAR2 mRNA encodes the human interferon alpha and beta receptor subunit 2 (IFNAR2) protein, a protein that belongs to the type II cytokine receptor family. IFNAR2 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2.

HY-174664

Human IFNB1 mRNA
Human IFNB1 mRNA encodes the human interferon beta 1 (IFNB1) protein, a cytokine that belongs to the interferon family. IFNB1 belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses.

HY-174663

Human IFNE mRNA
Human IFNE mRNA encodes the human interferon epsilon (IFNE) protein, a cytokine that belongs to the type I class of interferons. IFNE is required for maintaining basal levels of IFN-regulated genes, including 2''-5''-oligoadenylate synthetase, IRF7 and ISG15.

HY-174662

Human IFNG mRNA
Human IFNG mRNA encodes the human interferon gamma (IFNG) protein, a member of the type II interferon class. IFNG is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections.

HY-174661

Human IFNK mRNA
Human IFNK mRNA encodes the human interferon kappa (IFNK) protein, a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections.

HY-174660

Human IFNL1 mRNA
Human IFNL1 mRNA encodes the human interferon lambda 1 (IFNL1) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL1 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.

HY-174659

Human IFNL2 mRNA
Human IFNL2 mRNA encodes the human interferon lambda 2 (IFNL2) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL2 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.

HY-174658

Human IFNL3 mRNA
Human IFNL3 mRNA encodes the human interferon lambda 3 (IFNL3) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL3 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.

HY-174657

Human IFNLR1 mRNA
Human IFNLR1 mRNA encodes the human interferon lambda receptor 1 (IFNLR1) protein, a member of the class II cytokine receptor family. IFNLR1, interleukine 10 receptor and beta (IL10RB) form a receptor complex which has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29).

HY-174656

Human IFNW1 mRNA
Human IFNW1 mRNA encodes the human interferon omega 1 (IFNW1) protein, an interferon that possesses antiviral activity.

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