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Cat. No.: HY-183999

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17β-HSD10-IN-5

17β-HSD10-IN-5 is a potent 17β-HSD10 inhibitor with an IC₅₀ of 0.31 μM. 17β-HSD10-IN-5 can be used for the research of alzheimer’s disease.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₆ClN₃O₃S₂
Molecular Weight:397.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

17β-HSD10-IN-5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

17β-HSD10-IN-5 is a potent 17β-HSD10 inhibitor with an IC₅₀ of 0.31 μM. 17β-HSD10-IN-5 can be used for the research of alzheimer’s disease^[1].

All 17β-HSD Isoforms :

17β-HSD5/AKR1C3

In Vitro

17β-HSD10-IN-5 (compound 9b) (10-25 μM; 48 h) has negligible cytotoxicity and minimal ATP reduction in HEK293_wt cells in glucose medium, but shows significant ATP reduction and high cytotoxicity in galactose medium^[1].
17β-HSD10-IN-5 (10-25 μM; 2 h) potently inhibits 17β-HSD10 activity in HEK293 cells overexpressing 17β-HSD10 with an IC₅₀ of 1.34 μM^[1].
17β-HSD10-IN-5 (4.02 μM; 72 h) significantly increases ATP levels and reduces cytotoxicity, mitigating pathology in HEK293 cells overexpressing 17β-HSD10^[1].
17β-HSD10-IN-5 (4.02 μM; 72 h) does not mitigate ATP reduction or cytotoxicity in HEK293 cells overexpressing 17β-HSD10 in an Aβ42-enriched environment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293_wt cells
Concentration:

10; 25 μM
Incubation Time:

48 h
Result:

Showed negligible cytotoxicity in HEK293_wt cells in glucose medium.
Showed high cytotoxicity in HEK293_wt cells in galactose medium.

Chemical Information

Molecular Weight 397.90
Formula C₁₆H₁₆ClN₃O₃S₂
SMILES

CS(=O)(NC1=CC=C2N=C(NCCC3=CC=C(O)C(Cl)=C3)SC2=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marketa Sedlacek Miskerikova, et al. Development of Novel 17β-HSD10 Inhibitors and Their Evaluation in an In Vitro Model of Alzheimer’s Disease. ACS Medicinal Chemistry Letters Article ASAP.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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17β-HSD10-IN-5

All 17β-HSD Isoforms