1. Neuronal Signaling
  2. Amyloid-β
  3. β-Amyloid (10-35), amide

β-Amyloid (10-35), amide 

Cat. No.: HY-P1567
Handling Instructions

β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Amyloid (10-35), amide Chemical Structure

β-Amyloid (10-35), amide Chemical Structure

CAS No. : 181427-66-7

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Description

β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

In Vitro

β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

2902.33

Formula

C₁₃₃H₂₀₅N₃₅O₃₆S

CAS No.

181427-66-7

Sequence

Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2

Sequence Shortening

YEVHHQKLVFFAEDVGSNKGAIIGLM-NH2

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
β-Amyloid (10-35), amide
Cat. No.:
HY-P1567
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β-Amyloid (10-35), amide

Cat. No.: HY-P1567