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Aldehyde Oxidase

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標的別:	Aldehyde Oxidase (AO) (3) Monoamine Oxidase (2) Adenosine Receptor (1) Apoptosis (8) Biochemical Assay Reagents (6) c-Met/HGFR (7) DNA Stain (2) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (2) GABA Receptor (2) Histone Demethylase (2) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (1) Molecular Glues (2) NEKs (2) Parasite (3) Phosphodiesterase (PDE) (2) Reactive Oxygen Species (ROS) (2) Reference Standards (5) Sodium Channel (2)
研究分野別:	Cancer (15) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (4) Metabolic Disease (14) Neurological Disease (8)

標的別:

Aldehyde Oxidase (AO) (3)

Monoamine Oxidase (2)

Adenosine Receptor (1)

Apoptosis (8)

Biochemical Assay Reagents (6)

c-Met/HGFR (7)

DNA Stain (2)

Drug Derivative (1)

Drug Intermediate (2)

Endogenous Metabolite (2)

GABA Receptor (2)

Histone Demethylase (2)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

JAK (1)

Molecular Glues (2)

NEKs (2)

Parasite (3)

Phosphodiesterase (PDE) (2)

Reactive Oxygen Species (ROS) (2)

Reference Standards (5)

Sodium Channel (2)

研究分野別:

Cancer (15)

Cardiovascular Disease (2)

Infection (4)

Inflammation/Immunology (4)

Metabolic Disease (14)

Neurological Disease (8)

阻害剤およびアゴニスト

天然物

同位体標識化合物

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Targets Recommended: Aldehyde Oxidase (AO) Aldehyde Dehydrogenase (ALDH) Amino Acid Oxidase Lysyl Oxidase Glycolate Oxidase Xanthine Oxidase NADPH Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

製品番号	製品名	Target	研究分野	構造式

HY-13404

Capmatinib Maximum Cited Publications 24 Publications Verification INC280; INCB28060	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-13735

Quinacrine 5+ Cited Publications Acriquine	Parasite Sodium Channel DNA Stain Apoptosis Aldehyde Oxidase (AO)	Infection Neurological Disease Cancer
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human **aldehyde oxidase (IC₅₀**: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) .

HY-B1018A

Phenelzine sulfate 5+ Cited Publications	Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active *monoamine oxidase* (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO)*, and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1* (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-13404C

Capmatinib dihydrochloride hydrate Maximum Cited Publications 24 Publications Verification INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-I0637

Isovanillin 1 Publications Verification 3-Hydroxy-4-methoxybenzAldehyde	Others	Neurological Disease Metabolic Disease
Isovanillin is an **aldehyde oxidase** inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-B0051

Carbazeran	Phosphodiesterase (PDE)	Metabolic Disease
Carbazeran, a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran can be used for the research of metabolic disease .

HY-P2910

Galactose Oxidase, Dactylium dendroides 2 Publications Verification GOase	Endogenous Metabolite	Others
Galactose Oxidase, Dactylium dendroides (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide .

HY-W002016

Phthalazine	Reactive Oxygen Species (ROS)	Cancer
Phthalazine is a substrate for *human aldehyde* oxidase 1, which can lead to the production of ROS** and subsequent enzyme inactivation. Phthalazine is a nitrogen-containing organic heterocyclic compound. Phthalazine exhibits antitumor activity in blood cancer, breast cancer, colon cancer, lung cancer and renal cancer .

HY-13404A

Capmatinib dihydrochloride Maximum Cited Publications 24 Publications Verification INC280 dihydrochloride; INCB28060 dihydrochloride	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-13404B

Capmatinib hydrochloride Maximum Cited Publications 24 Publications Verification INC280 hydrochloride; INCB-28060 hydrochloride	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-P2743

Choline oxidase	Biochemical Assay Reagents	Others
Choline oxidase (EC 1.1.3.17) catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production .

HY-W599279

ABS-752	Molecular Glues NEKs	Cancer
ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma .

HY-I0637S

Isovanillin-d3 3-Hydroxy-4-methoxybenzAldehyde-d₃	Isotope-Labeled Compounds	Metabolic Disease
Isovanillin-d₃ is the deuterium labeled Isovanillin . Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-W103317

1,2-Benzisoxazole Indoxazene	Drug Intermediate	Neurological Disease
1,2-Benzisoxazole (Indoxazene) is a potential substrate of rabbit liver aldehyde oxidase. 1,2-Benzisoxazole was used in the discovery and development of zonisamide (HY-B0124) for the study of epilepsy and Parkinson's disease .

HY-B1018AS

Phenelzine-d5 sulfate	Isotope-Labeled Compounds Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active *monoamine oxidase* (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO)*, and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1* (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-Z4483

6-Deoxypenciclovir	Drug Intermediate	Others
6-Deoxypenciclovir is an inactive metabolite of the antiviral prodrug Famciclovir. 6-Deoxypenciclovir is a good substrate for rabbit hepatic aldehyde oxidase and can be used to synthesize the prodrug form of penciclovir .

HY-13735R

Quinacrine (Standard) Acriquine (Standard)	Parasite Sodium Channel DNA Stain Apoptosis Reference Standards	Infection Neurological Disease Cancer
Quinacrine (Standard) is the analytical standard of Quinacrine. This product is intended for research and analytical applications. Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) .

HY-157794

6-Nitroquinazoline	Parasite	Infection
6-Nitroquinazoline is an antimalarial agent. 6-Nitroquinazoline is also a substrate for human liver aldehyde oxidase .

HY-19844

ANA-975	Drug Derivative Aldehyde Oxidase (AO)	Infection
ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine (HY-13655A). ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by **aldehyde oxidase**. ANA975 can be used in the research of hepatitis C virus infection .

HY-13404R

Capmatinib (Standard) INC280 (Standard); INCB28060 (Standard)	Reference Standards c-Met/HGFR Apoptosis	Cancer
Capmatinib (Standard) is the analytical standard of Capmatinib. This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-108680

Carbazeran citrate	Phosphodiesterase (PDE)	Metabolic Disease
Carbazeran (citrate), a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran (citrate) can be used for the research of metabolic disease .

HY-144075

JAK-IN-19	JAK	Inflammation/Immunology
JAK-IN-19 is a potent JAK inhibitor (PBMC IFNγ pIC₅₀=7.2 and HLF Eotaxin pIC₅₀=7.7). JAK-IN-19 has good retentive properties in the lung via mitigating being metabolized by Aldehyde Oxidase (AO), with diminished VEGFR2 selectivity (VEGFR2 pIC₅₀=7.0, Aurora B pIC₅₀=5.8) .

HY-I0637R

Isovanillin (Standard) 3-Hydroxy-4-methoxybenzAldehyde (Standard)	Reference Standards Others	Neurological Disease Metabolic Disease
Isovanillin (Standard) is the analytical standard of Isovanillin. This product is intended for research and analytical applications. Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-50683S

JNJ-38877605-d1	c-Met/HGFR	Cancer
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

HY-W002016R

Phthalazine (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Cancer
Phthalazine (Standard) is the analytical standard of Phthalazine. This product is intended for research and analytical applications. Phthalazine is a substrate for *human aldehyde* oxidase 1, which can lead to the production of ROS** and subsequent enzyme inactivation. Phthalazine is a nitrogen-containing organic heterocyclic compound. Phthalazine exhibits antitumor activity in blood cancer, breast cancer, colon cancer, lung cancer and renal cancer .

HY-13404CR

Capmatinib dihydrochloride hydrate (Standard) INC280 dihydrochloride hydrate (Standard); INCB-28060 dihydrochloride hydrate (Standard)	c-Met/HGFR Apoptosis Reference Standards	Cancer
Capmatinib (dihydrochloride hydrate) (Standard) is the analytical standard of Capmatinib (dihydrochloride hydrate). This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-W142745

Phenanthridine	Aldehyde Oxidase (AO)	Metabolic Disease
Phenanthridine is an aldehyde oxidase 1 (AOX1) substrate, with oxidation by hAOX1 yielding phenanthridone when molecular oxygen, ferricyanide, or dichlorophenolindophenol serves as electron acceptor .

HY-E70385A

Oxalate oxidase, B. subtilis	Endogenous Metabolite	Metabolic Disease
Oxalate oxidase, B. subtilis (EC 1.2.3.4) is a redox enzyme that acts on the donor aldehyde or carbonyl group, using oxygen as the acceptor. Oxalate oxidase, B is involved in the metabolism of glyoxylate and dicarboxylic acids. Oxalate oxidase, B has two cofactors: FAD and manganese. Oxalate oxidase, B has three substrates: oxalic acid, O₂, and H ⁺, and two products: CO₂ and H₂O₂.

HY-P2743B

Choline oxidase, Arthrobacter globiformis	Biochemical Assay Reagents	Metabolic Disease
Choline oxidase, Arthrobacter globiformis (EC 1.1.3.17) is an oxidoreductase that acts on the CH-OH group in a donor molecule and uses oxygen as an acceptor. The two substrates of Choline oxidase, Arthrobacter globiformis (EC 1.1.3.17) are choline and O2, and the two products are betaine aldehyde and H2O2.

HY-P2743A

Choline Oxidase, Alcaligenes sp.	Biochemical Assay Reagents	Metabolic Disease
Choline oxidase, Alcaligenes sp. (EC 1.1.3.17) is an oxidoreductase that acts on the CH-OH group in a donor molecule and uses oxygen as an acceptor. The two substrates of Choline oxidase, Alcaligenes sp. (EC 1.1.3.17) are choline and O2, and the two products are betaine aldehyde and H2O2.

HY-P2756B

Alcohol Oxidase, Pichia pastoris	Biochemical Assay Reagents	Metabolic Disease
Alcohol Oxidase, Pichia pastoris (EC 1.1.3.13) is a redox enzyme that acts on the CH-OH group in donor molecules and uses oxygen as an acceptor. The two substrates of Alcohol Oxidase, Pichia pastoris (EC 1.1.3.13) are primary alcohols and O2, while its two products are aldehydes and H2O2.

HY-P2756A

Alcohol Oxidase, Hansenula sp.	Biochemical Assay Reagents	Metabolic Disease
Alcohol oxidase, Hansenula sp. (EC 1.1.3.13) is a redox enzyme that acts on the CH-OH group in donor molecules and uses oxygen as an acceptor. The two substrates of Alcohol Oxidase, Hansenula sp. (EC 1.1.3.13) are primary alcohols and O2, while its two products are aldehydes and H2O2.

HY-E70519B

Tyramine Oxidase, Arthrobacter sp.	Biochemical Assay Reagents	Metabolic Disease
Tyramine oxidase, Arthrobacter sp. (EC 1.4.3.6) is a class of enzymes that catalyze the oxidation of various biogenic amines, including many neurotransmitters, histamine, and exogenous amines. Tyramine oxidase, Arthrobacter sp. (EC 1.4.3.6) catalyzes the oxidation of primary amines to aldehydes, releasing ammonia and hydrogen peroxide. Each subunit of this reaction requires a copper ion, with topiramate as a cofactor.

HY-404647

FK3453	Interleukin Related Adenosine Receptor	Neurological Disease Inflammation/Immunology
FK3453 is a dual adenosine A1/A2 inhibitor and a TSLP inhibitor. FK3453 is also a substrate of aldehyde oxidase (AO). FK3453 can inhibit the production of TSLP and IL-33. FK3453 is useful for research on Parkinson’s disease and allergic disorders .

HY-W998347

ABS-752 hydrochloride	Molecular Glues NEKs	Cancer
ABS-752 is an orally active prodrug of CRBN-modulating molecular glue targeting. ABS-752 can effectively degrade GSPT1. ABS-752 can degrade NEK7. ABS-752 does not form ternary complexes with CRBN and the neosubstrates. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002. ABS-752 can be used for the study of hepatocellular carcinoma (HCC) .

Isovanillin 1 Publications Verification 3-Hydroxy-4-methoxybenzAldehyde	Monophenols Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Source Classification	Others
Isovanillin is an **aldehyde oxidase** inhibitor . Antispasmodic activities . Antidiarrheal activities .

Isovanillin (Standard) 3-Hydroxy-4-methoxybenzAldehyde (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Source Classification	Reference Standards Others
Isovanillin (Standard) is the analytical standard of Isovanillin. This product is intended for research and analytical applications. Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

製品番号	製品名	構造式

HY-I0637S

Isovanillin-d3
Isovanillin-d₃ is the deuterium labeled Isovanillin . Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-B1018AS

Phenelzine-d5 sulfate
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active *monoamine oxidase* (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO)*, and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1* (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

Phenelzine-d5 sulfate

Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P86780

	Aldehyde Oxidase Antibody (YA6473) Aldehyde Oxidase 1 antibody; AO antibody; AOH1 antibody; AOX 1 antibody; azaheterocycle hydroxylase antibody; EC 1.2.3.1 antibody;	WB, IHC-P, FC	Human, Mouse, Rat
	Aldehyde Oxidase Antibody (YA6473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aldehyde Oxidase.

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