Aldehyde Oxidase Antibody (YA6473)
(Synonyms: Aldehyde oxidase 1 antibody; AO antibody; AOH1 antibody; AOX 1 antibody; azaheterocycle hydroxylase antibody; EC 1.2.3.1 antibody; )
Based on 1 Customer Validation
Aldehyde Oxidase Antibody (YA6473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aldehyde Oxidase.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:500 | 1:200-1:1000 | 1:500-1:1000 |
Product Details
Aldehyde Oxidase Antibody (YA6473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aldehyde Oxidase.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 148 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 148 kDa
Synthetic peptide within human AOX1 aa 1301-1338 / 1338.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Aldehyde Oxidase is an Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level)
Induction: In liver, is down-regulated by adiponectin and by the PPARA agonist, fenofibric acid -
Isoforms & Post-Translational Modification
Q06278: 1338 amino acids, molecular weight 147918 Da.
Phosphorylated at Ser-533 following infection of macrophages with S -
Subunit
Homodimer
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SwissProt ID
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Synonyms
Aldehyde oxidase 1 antibody; AO antibody; AOH1 antibody; AOX 1 antibody; azaheterocycle hydroxylase antibody; EC 1.2.3.1 antibody;
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