Aldehyde Oxidase Antibody (YA6473)

Cat. No.: HY-P86780: Data Sheet User Guide for Antibodies
FAQs
Technical Support

Aldehyde Oxidase Antibody (YA6473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aldehyde Oxidase.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Aldehyde Oxidase Antibody (YA6473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aldehyde Oxidase.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 148 kDa;

Observed band size: 148 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q06278

Gene ID

316 [NCBI]

Immunogen

Synthetic peptide within human AOX1 aa 1,301-1,338 / 1,338.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:500-1:1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis

Subcellular Localization：Cytoplasm

Expression：
Tissue_Specificity: Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level)
Induction: In liver, is down-regulated by adiponectin and by the PPARA agonist, fenofibric acid

Isoforms & Post-Translational Modification：Q06278: 1338 amino acids, molecular weight 147918 Da.
Phosphorylated at Ser-533 following infection of macrophages with S

Subunit：Homodimer

Synonyms

Aldehyde oxidase 1 antibody; AO antibody; AOH1 antibody; AOX 1 antibody; azaheterocycle hydroxylase antibody; EC 1.2.3.1 antibody;

Documentation

User Guide for Antibodies (1077 KB)