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B1473

" in MedChemExpress (MCE) Product Catalog:

27

Inhibitors & Agonists

5

Natural
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6

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1473A
    Serotonin
    30+ Cited Publications

    5-Hydroxytryptamine; 5-HT

    		 5-HT Receptor COMT Endogenous Metabolite Neurological Disease
    Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
    Serotonin
  • HY-B1473
    Serotonin hydrochloride
    30+ Cited Publications

    5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride

    		 5-HT Receptor COMT Endogenous Metabolite Neurological Disease
    Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist, with blood-brain barrier permeability. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
    Serotonin hydrochloride
  • HY-B1473AS
    Serotonin-d4

    5-Hydroxytryptamine-d4; 5-HT-d4

    		 Isotope-Labeled Compounds 5-HT Receptor COMT Endogenous Metabolite Neurological Disease
    Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
    Serotonin-d4
  • HY-B1473S
    Serotonin-d4 hydrochloride

    5-Hydroxytryptamine-d4 hydrochloride; 5-HT-d4 hydrochloride

    		 Isotope-Labeled Compounds 5-HT Receptor Endogenous Metabolite COMT Others
    Serotonin-d4 (5-Hydroxytryptamine-d4) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
    Serotonin-d4 hydrochloride
  • HY-B1473R
    Serotonin hydrochloride (Standard)

    5-Hydroxytryptamine hydrochloride (Standard); 5-HT hydrochloride (Standard)

    		 5-HT Receptor Reference Standards COMT Endogenous Metabolite Neurological Disease
    Serotonin (5-Hydroxytryptamine) (Standard) hydrochloride is the analytical standard of Serotonin hydrochloride (HY-B1473). This product is intended for research and analytical applications. Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
    Serotonin hydrochloride (Standard)
  • HY-B1473S2
    Serotonin-13C,D4

    5-Hydroxytryptamine-13C,D4; 5-HT-13C,D4

    		 Isotope-Labeled Compounds 5-HT Receptor COMT Endogenous Metabolite Neurological Disease
    Serotonin- 13C,D4 (5-Hydroxytryptamine-13C,D4) is a 13C- and deuterated labeled Serotonin (HY-B1473A). Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
    Serotonin-13C,D4
  • HY-B0168A
    Milnacipran hydrochloride
    2 Publications Verification

    		 Serotonin Transporter PERK Neurological Disease
    Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
    Milnacipran hydrochloride
  • HY-B1107
    Naftidrofuryl oxalate

    Nafronyl oxalate salt

    		 5-HT Receptor Cardiovascular Disease
    Naftidrofuryl oxalate (Nafronyl oxalate salt) is an orally active 5-HT2 receptor antagonist. Naftidrofuryl oxalate selectively blocks vascular and platelet 5-HT2 receptors, inhibiting Serotonin (HY-B1473A)-induced vasoconstriction, platelet aggregation, and vascular smooth muscle cell proliferation. Naftidrofuryl oxalate can be used for the research of intermittent claudication, peripheral occlusive arterial disease, and critical limb ischaemia .
    Naftidrofuryl oxalate
  • HY-156562A
    5-PT formic
    1 Publications Verification

    5-Propargyltryptamide formic

    		 Drug Derivative Inflammation/Immunology
    5-PT (5-Propargyltryptamide) formic is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT formic conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT formic labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT formic can be used for the research of bronchopulmonary dysplasia .
    5-PT formic
  • HY-101172
    RS 23597-190

    EP-A-501322

    		 5-HT Receptor Cardiovascular Disease
    RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits Serotonin (HY-B1473A)-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose .
    RS 23597-190
  • HY-W017158
    Melilotic acid

    		Endogenous Metabolite Endocrinology
    Melilotic acid (3-(2-hydroxyphenyl)-propanoic acid) is an orally active compound. Melilotic acid can be isolated from the bark of Chinese cinnamon. Melilotic acid has a significant inhibitory effect on gastric ulcers induced by serotonin (HY-B1473A), phenylbutazone (HY-B0230), ethanoyl, and water immersion stress .
    Melilotic acid
  • HY-156562
    5-PT

    5-Propargyltryptamide

    		 Drug Derivative Inflammation/Immunology
    5-PT (5-Propargyltryptamide) is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT can be used for the research of bronchopulmonary dysplasia .
    5-PT
  • HY-14794
    Dextromilnacipran

    (1R,2S)-Milnacipran; F2696

    		 Serotonin Transporter Adrenergic Receptor Neurological Disease Metabolic Disease
    Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia .
    Dextromilnacipran
  • HY-B0168
    Milnacipran
    2 Publications Verification

    		 Serotonin Transporter PERK Neurological Disease
    Milnacipran is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran inhibits pERK1/2 activation. Milnacipran has antidepressant, anxiolytic and analgesic properties. Milnacipran inhibits biting behavior in mice. Milnacipran can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
    Milnacipran
  • HY-15386
    Cimoxatone

    MD 780515

    		 Monoamine Oxidase Metabolic Disease
    Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A) .
    Cimoxatone
  • HY-W017158R
    Melilotic acid (Standard)

    		Reference Standards Endogenous Metabolite Endocrinology
    Melilotic acid (Standard) is an analytical standard for Melilotic acid (HY-W017158). This product is intended for research and analytical applications. Melilotic acid (3-(2-hydroxyphenyl)-propanoic acid) is an orally active compound. Melilotic acid can be isolated from the bark of Chinese cinnamon. Melilotic acid has a significant inhibitory effect on gastric ulcers induced by serotonin (HY-B1473A), phenylbutazone (HY-B0230), ethanoyl, and water immersion stress .
    Melilotic acid (Standard)
  • HY-14794S
    Dextromilnacipran-d6

    (1R,2S)-Milnacipran-d6; F2696-d6

    		 Isotope-Labeled Compounds Serotonin Transporter Adrenergic Receptor Metabolic Disease
    Dextromilnacipran-d6 is the deuterium labeled Dextromilnacipran (HY-14794). Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia .
    Dextromilnacipran-d6
  • HY-B0168S
    Milnacipran-d10 hydrochloride

    		Isotope-Labeled Compounds Serotonin Transporter PERK Neurological Disease
    Milnacipran-d10 (hydrochloride) is the deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
    Milnacipran-d10 hydrochloride
  • HY-123199
    Serotonin azidobenzamidine

    SABA

    		 Serotonin Transporter Neurological Disease
    Serotonin azidobenzamidine is an arylazido derivative of 5-hydroxytryptamine (HY-B1473A). Serotonin azidobenzamide competitively inhibits [3H]5-hydroxytryptamine uptake by rat cortical synaptosomes in the dark with a Ki of 130 nM .
    Serotonin azidobenzamidine
  • HY-164009
    Teniloxazine

    		Adrenergic Receptor Dopamine Receptor 5-HT Receptor Neurological Disease
    Teniloxazine is an inhibitor for norepinephrine neuronal reuptake and an weak inhibitor for reuptake of Serotonin (HY-B1473A) and Dopamine (HY-B0451). Teniloxazine exhibits antidepressant, antihypoxic and anti-amnestic properties without anticholinergic, sedative, and cardiovascular adverse effects .
    Teniloxazine
  • HY-121208
    Ketanserinol

    R 46742

    		 5-HT Receptor Drug Metabolite Neurological Disease
    Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562). Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The KB values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries .
    Ketanserinol
  • HY-117223
    GEA 857

    		Potassium Channel Neurological Disease
    GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases .
    GEA 857
  • HY-105449A
    KB R6933

    KB 6806 maleate

    		 5-HT Receptor Cardiovascular Disease
    KB R6933 (KB 6806 maleate) is a potent, selective and orally active 5-HT3 receptor antagonist. KB R6933 can inhibit the diarrhea induced by 5-HT (HY-B1473A), but not that by Castor Oil (HY-107799) or prostaglandin E2 (PGE2) (HY-101952). KB R6933 can inhibit 5-HT-induced bradycardia .
    KB R6933
  • HY-B0168AS
    Milnacipran-d5 hydrochloride

    		Isotope-Labeled Compounds Serotonin Transporter PERK Neurological Disease
    Milnacipran-d5 hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
    Milnacipran-d5 hydrochloride
  • HY-B0168AR
    Milnacipran hydrochloride (Standard)

    		Reference Standards Serotonin Transporter PERK Neurological Disease
    Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran hydrochloride (HY-B0168A). This product is intended for research and analytical applications. Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
    Milnacipran hydrochloride (Standard)
  • HY-14794B
    Dextromilnacipran hydrochloride

    (1R,2S)-Milnacipran hydrochloride; F2696 hydrochloride

    		 Serotonin Transporter Adrenergic Receptor Neurological Disease
    Dextromilnacipran ((1R,2S)-Milnacipran; F2696) hydrochloride is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran hydrochloride inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran hydrochloride can be used for the research of depression, fibromyalgia .
    Dextromilnacipran hydrochloride
  • HY-101172R
    RS 23597-190 (Standard)

    EP-A-501322 (Standard)

    		 5-HT Receptor Reference Standards Cardiovascular Disease
    RS 23597-190 (Standard) is the analytical standard of RS 23597-190 (HY-101172). This product is intended for research and analytical applications. RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits Serotonin (HY-B1473A)-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose .
    RS 23597-190 (Standard)

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