1. Neuronal Signaling
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  3. Milnacipran hydrochloride

Milnacipran hydrochloride 

Cat. No.: HY-B0168A Purity: 99.40%
Handling Instructions

Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.

For research use only. We do not sell to patients.

Milnacipran hydrochloride Chemical Structure

Milnacipran hydrochloride Chemical Structure

CAS No. : 101152-94-7

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10 mM * 1 mL in DMSO USD 75 In-stock
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10 mg USD 68 In-stock
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50 mg USD 227 In-stock
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100 mg USD 341 In-stock
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Description

Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Target: SNRI Milnacipran (Ixel, Savella, Dalcipran, Toledomin) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA, but it is in other countries. Milnacipran inhibits the reuptake of serotonin and norepinephrine in an approximately 1:3 ratio, respectively; in practical use this means a relatively balanced action upon bothneurotransmitters. Increasing both neurotransmitters concentration simultaneously works synergistically to treat both depression and fibromyalgia. Milnacipran exerts no significant actions onH1, α1, D1, D2, and mACh receptors, as well as on benzodiazepine and opioid binding sites. Milnacipran is well absorbed after oral dosing and has a bioavailability of 85%. Meals do not have an influence on the rapidity and extent of absorption. Peak plasma concentrations are reached 2 hours after oral dosing. The elimination half-life of 8 hours is not increased by liver impairment and old age, but by significant renal disease. Milnacipran is conjugated to the inactive glucuronide and excreted in the urine as unchanged drug and conjugate. Only traces of active metabolites are found.

Molecular Weight

282.81

Formula

C₁₅H₂₃ClN₂O

CAS No.

101152-94-7

SMILES

O=C([[email protected]@]1(C2=CC=CC=C2)[[email protected]@H](CN)C1)N(CC)CC.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 48 mg/mL (169.73 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5359 mL 17.6797 mL 35.3594 mL
5 mM 0.7072 mL 3.5359 mL 7.0719 mL
10 mM 0.3536 mL 1.7680 mL 3.5359 mL
*Please refer to the solubility information to select the appropriate solvent.
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Milnacipran hydrochloride
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