1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. RS 23597-190

RS 23597-190  (Synonyms: EP-A-501322)

Cat. No.: HY-101172
Handling Instructions

RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose.

For research use only. We do not sell to patients.

RS 23597-190 Chemical Structure

RS 23597-190 Chemical Structure

CAS No. : 149719-06-2

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Description

RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].

IC50 & Target[1]

5-HT4 Receptor

 

In Vitro

RS 23597-190 (10 µM; 4 days) significantly inhibits superoxide production in high glucose (30 mM) in 661W cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RS 23597-190 (6.0 mg/kg; i.v.) inhibits 5-HT-induced tachycardia in micropig[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bilaterally vagotomized micropig[1]
Dosage: 6.0 mg/kg
Administration: I.v.
Result: Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min.
Molecular Weight

363.28

Formula

C16H24Cl2N2O3

CAS No.
SMILES

O=C(OCCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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RS 23597-190 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RS 23597-190
Cat. No.:
HY-101172
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