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Cat. No.: HY-156562

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5-PT

(Synonyms: 5-Propargyltryptamide)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

5-PT (5-Propargyltryptamide) is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT can be used for the research of bronchopulmonary dysplasia.

For research use only. We do not sell to patients.

CAS No.: 92085-05-7
Formula: C₁₃H₁₄N₂O
Molecular Weight:214.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

5-PT Chemical Structure

CAS No.: 92085-05-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

5-PT (100 μM; 24 h) treatment of MLE-12 alveolar epithelial cells labels 121 unique serotonylated proteins, many of which are associated with cellular processes and cell behavior regulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 92085-05-7
Molecular Weight 214.26
Formula C₁₃H₁₄N₂O
SMILES

NCCC1=CNC2=C1C=C(OCC#C)C=C2
Synonyms

5-Propargyltryptamide
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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iScience

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. [Abstract]

2025 Nov 19;28(12):114120. PMID: 41438086

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cai P, et al. 5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. iScience. 2025;28(12):114120. Published 2025 Nov 19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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