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  3. Drug Derivative
  4. 5-PT

5-PT (5-Propargyltryptamide) is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT can be used for the research of bronchopulmonary dysplasia.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (5-PT formic) that retains the same biological activity.

For research use only. We do not sell to patients.

5-PT

5-PT Chemical Structure

CAS No. : 92085-05-7

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5-PT Related Antibodies

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Description

5-PT (5-Propargyltryptamide) is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT can be used for the research of bronchopulmonary dysplasia[1].

In Vitro

5-PT (100 μM; 24 h) treatment of MLE-12 alveolar epithelial cells labels 121 unique serotonylated proteins, many of which are associated with cellular processes and cell behavior regulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-PT Related Antibodies
Molecular Weight

214.26

Formula

C13H14N2O
CAS No.
SMILES

NCCC1=CNC2=C1C=C(OCC#C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5-PT Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-PT92085-05-75-PropargyltryptamideDrug DerivativeDrug derivativealveolar epithelial cellsbronchopulmonary dysplasiaMLE-12serotonylation5-HTInhibitorinhibitorinhibit

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