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Results for "

Beta-Carboline

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (3) Apoptosis (3) Autophagy (2) CDK (4) Cholinesterase (ChE) (1) Cytochrome P450 (1) Endogenous Metabolite (2) ERK (1) GABA Receptor (1) GSK-3 (2) HSV (2) Imidazoline Receptor (3) Isotope-Labeled Compounds (1) JNK (1) Microtubule/Tubulin (1) Monoamine Oxidase (6) Parasite (4) Proton Pump (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (9) Infection (8) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (9)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Amyloid-β TGF-β Receptor Beta-secretase TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Beta-lactamase Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1633

1-Methoxycarbonyl-β-carboline

Others Others

1-Methoxycarbonyl-β-carboline is a natural alkaloid .

1-Methoxycarbonyl-β-carboline	Others	Others
1-Methoxycarbonyl-β-carboline is a natural alkaloid .

HY-150511

3-(3-Phenoxybenzyl)amino-β-carboline	Microtubule/Tubulin Apoptosis	Cancer
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity .

HY-N2926

β-Carboline-1-propionic acid	Parasite	Infection
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .

HY-N1905

4-Methoxy-β-carboline-1-carboxylic acid methylester

4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .
HY-N11016

1-Methoxymethyl-β-carboline

Others Others

1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .

*4-Methoxy-β-carboline-1-carboxylic acid methylester*
4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline .

1-Methoxymethyl-β-carboline	Others	Others
1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .

HY-N7173

*7-Methoxy-β-carboline-1-propionic acid*	Parasite	Infection
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-20696

Tetrahydro-β-carboline Tryptoline	5-HT Receptor	Metabolic Disease
Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an K_i value of 6.1 µM .

HY-N9009

1-Hydroxymethyl-β-carboline glucoside

Others Others

1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides .

*1-Hydroxymethyl-β-carboline* glucoside**	Others	Others
1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides .

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-Carboline	Reactive Oxygen Species	Inflammation/Immunology
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-33169

1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid

1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid is a chemical used on the study of neurodegenerative diseases .
HY-W060074

1-Acetyl-β-carboline

1-(9H-pyrido[3,4-b]indol-1-yl)ethanone
Others Infection

1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica .

*1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid*
1,2,3,4-Tetrahydro-β-carboline-1-carboxylic acid is a chemical used on the study of neurodegenerative diseases .

1-Acetyl-β-carboline 1-(9H-pyrido[3,4-b]indol-1-yl)ethanone	Others	Infection
1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica .

HY-W008566

Norharmane Norharman; β-Carboline	Monoamine Oxidase Endogenous Metabolite	Infection Neurological Disease Cancer
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	GSK-3 CDK Parasite Proton Pump HSV Autophagy	Infection Neurological Disease Cancer
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically *GSK-3β* and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 .

HY-117025

Manzamine A Keramamine A	GSK-3 CDK Parasite Proton Pump HSV Autophagy	Infection Neurological Disease Cancer
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically *GSK-3β* and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 .

HY-107811A

Harmol hydrochloride

Monoamine Oxidase Others

Harmol hydrochloride categorized as a β-carboline alkaloid. Harmol hydrochloride is a potent MAO inhibitor .
HY-N10960

Stellarine C

Others Others

Stellarine C is a β-carboline alkaloid that can be isolated from Stellaria dichotoma var. lanceolata .
HY-107811

Harmol

Monoamine Oxidase Neurological Disease

Harmol categorized as a β-carboline alkaloid. Harmol is a potent MAO inhibitor used as an analytical reference standard .
HY-N10386

Dichotomine B

Others Inflammation/Immunology

Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .

Harmol hydrochloride	Monoamine Oxidase	Others
Harmol hydrochloride categorized as a β-carboline alkaloid. Harmol hydrochloride is a potent MAO inhibitor .

Stellarine C	Others	Others
Stellarine C is a β-carboline alkaloid that can be isolated from Stellaria dichotoma var. lanceolata .

Harmol	Monoamine Oxidase	Neurological Disease
Harmol categorized as a β-carboline alkaloid. Harmol is a potent MAO inhibitor used as an analytical reference standard .

Dichotomine B	Others	Inflammation/Immunology
Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .

HY-N3711

Dehydrocrenatine	JNK ERK Apoptosis	Neurological Disease
Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects .

HY-N2625A

Harmalol hydrochloride	Cytochrome P450	Others
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .

HY-154993

Gamma-Glutamyl Transferase-IN-1	Others	Infection
Gamma-Glutamyl Transferase-IN-1 (compound 4de) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-1 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation .

HY-154996

Gamma-Glutamyl Transferase-IN-2	Others	Infection
Gamma-Glutamyl Transferase-IN-2 (compound 4dq) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-2 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation .

HY-115909

ZDLD20	CDK	Cancer
ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC₅₀ value of 6.51 μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity .

HY-115908

ZDLD13	CDK Apoptosis	Cancer
ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC₅₀ value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD13 shows significant tumor growth inhibition in HCT116 tumor xenograft model .

HY-101392

Harmane 1 Publications Verification
Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .

HY-101392S

Harmane-d1	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S1

Harmane-d2	Isotope-Labeled Compounds Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-P5189A

*His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA*	Endogenous Metabolite Cholinesterase (ChE)	Others
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels .

HY-101392R

Harmane (Standard)	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .

HY-105115

Abecarnil ZK 112119	GABA Receptor	Neurological Disease
Abecarnil (ZK 112119) is a ligand or a partial agonist for benzodiazepine (BZ) receptor. Abecarnil possesses anxiolytic and anticonvulsant properties. Abecarnil can act as a positive allosteric modulator of GABA_A receptor. Abecarnil inhibits the binding of the BZ [3H]lormetazepam to rat cerebral cortex membranes, with an IC₅₀ of 0.82 nM. Abecarnil can be used for epilepsy research .

β-Aspartylalanine	Peptides	Others
β-Aspartylalanine is a substrate for β-aspartyl peptidase and used to measure β-aspartyl peptidase activity in fecal supernatants .

*His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA*	Endogenous Metabolite Cholinesterase (ChE)	Others
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1633

1-Methoxycarbonyl-β-carboline	Alkaloids Simaroubaceae Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Plants Disease Research Fields Indole Alkaloids	Others
1-Methoxycarbonyl-β-carboline is a natural alkaloid .

HY-N2926

β-Carboline-1-propionic acid	Structural Classification Alkaloids Simaroubaceae Ailanthus altissima (Mill.) Swingle Pyrrole Alkaloids Source classification Plants	Parasite
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .

HY-N11016

1-Methoxymethyl-β-carboline	Structural Classification Alkaloids Simaroubaceae Source classification Pyridine Alkaloids Plants	Others
1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .

HY-N7173

*7-Methoxy-β-carboline-1-propionic acid*	Alkaloids Structural Classification other families Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants	Parasite
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N9009

*1-Hydroxymethyl-β-carboline* glucoside**	Alkaloids Classification of Application Fields Animals Source classification Other Diseases Pyridine Alkaloids Disease Research Fields Indole Alkaloids	Others
1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides .

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-Carboline	Alkaloids Simaroubaceae Source classification Plants Picrasma quassioides(D．Don)Benn． Indole Alkaloids	Reactive Oxygen Species
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-W060074

1-Acetyl-β-carboline 1-(9H-pyrido[3,4-b]indol-1-yl)ethanone	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Pyridine Alkaloids Disease Research Fields Indole Alkaloids	Others
1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica .

HY-W008566

Norharmane Norharman; β-Carboline	Structural Classification Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Biological Pesticide Research Indole Alkaloids Agricultural Research Infection Alkaloids Microorganisms Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Source classification Marine natural products Pyridine Alkaloids Indole Alkaloids Infection Alkaloids Piperidine Alkaloids Animals Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically *GSK-3β* and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically *GSK-3β* and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 .

HY-N10960

Stellarine C	Structural Classification Alkaloids Pyrrole Alkaloids Stellaria dichotoma var. lanceolata Bge. Source classification Pyridine Alkaloids Plants Caryophyllaceae	Others
Stellarine C is a β-carboline alkaloid that can be isolated from Stellaria dichotoma var. lanceolata .

HY-107811

Harmol	Neurological Disease Classification of Application Fields Source classification Peganum harmala Linn. Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids Alkaloids Monophenols Zygophyllaceae Phenols Disease Research Fields	Monoamine Oxidase
Harmol categorized as a β-carboline alkaloid. Harmol is a potent MAO inhibitor used as an analytical reference standard .

HY-N3711

Dehydrocrenatine	Simaroubaceae Source classification Plants Indole Alkaloids Picrasma chinensis P. Y. Chen	JNK ERK Apoptosis
Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects .

HY-N2625A

Harmalol hydrochloride	Alkaloids Structural Classification Monophenols Classification of Application Fields Zygophyllaceae Source classification Peganum harmala Linn. Other Diseases Phenols Pyridine Alkaloids Plants Disease Research Fields	Cytochrome P450
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .

HY-101392R

Harmane (Standard)	Structural Classification Alkaloids other families Source classification Plants	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .

Cat. No.	Product Name	Chemical Structure

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

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