1. Neuronal Signaling
    GPCR/G Protein
  2. Imidazoline Receptor
    Monoamine Oxidase
    Adrenergic Receptor
  3. Harmane-d1

Harmane-d1 

Cat. No.: HY-101392S Purity: 98.01%
COA Handling Instructions

Harmane-d1 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively).

For research use only. We do not sell to patients.

Harmane-d1 Chemical Structure

Harmane-d1 Chemical Structure

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5 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 3050 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Harmane-d1 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

183.23

Formula

C12H9DN2

SMILES

CC1=NC([2H])=CC2=C1NC3=C2C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (272.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4576 mL 27.2881 mL 54.5762 mL
5 mM 1.0915 mL 5.4576 mL 10.9152 mL
10 mM 0.5458 mL 2.7288 mL 5.4576 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.01%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Harmane-d1
Cat. No.:
HY-101392S
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