26 Results for "

Caspase-6

" in MedChemExpress (MCE) Product Catalog:
Products (26)

26 Results for "Caspase-6" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P5983
CAS No.: 210345-01-0
Target:  

Caspase

Research Areas:  

Cancer

Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
loading...
    loading...
Cat. No.: HY-P1007
CAS No.: 210344-96-0
Synonyms: Z-VE(OMe)ID(OMe)-FMK
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .
loading...
    loading...
Cat. No.: HY-137038
CAS No.: 4238-41-9
Synonyms: TLCK hydrochloride
Research Areas:  

Cardiovascular Disease Cancer

N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC50 of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases .
loading...
    loading...
Cat. No.: HY-P2065
CAS No.: 219137-97-0
Target:  

Fluorescent Dye

Research Areas:  

Others

Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
loading...
    loading...
Cat. No.: HY-108312A
Purity:  98.7%
Target:  

Caspase

Research Areas:  

Neurological Disease

Ac-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. Ac-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .
loading...
    loading...
Cat. No.: HY-N3000
CAS No.: 72401-54-8
6-Methoxydihydrosanguinarine is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and caspases. 6-Methoxydihydrosanguinarine induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine disruptes the biofilm formation of Candida albicans (C. albicans). 6-Methoxydihydrosanguinarine can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer [6] .
loading...
    loading...
Cat. No.: HY-125194
CAS No.: 2267318-43-2
Target:  

Caspase

Research Areas:  

Neurological Disease

NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC50 value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease .
loading...
    loading...
Cat. No.: HY-108312
CAS No.: 319494-39-8
Target:  

Caspase

Research Areas:  

Neurological Disease

Ac-VEID-CHO is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. Ac-VEID-CHO also inhibits VEIDase activity an IC50 value of 0.49 µM. Ac-VEID-CHO can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .
loading...
    loading...
Cat. No.: HY-P10822
CAS No.: 1593480-56-8
Target:  

Caspase

Research Areas:  

Neurological Disease

ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. ED11 competes with Htt for the caspase-6 active site, and thus reduce Htt cleavage. ED11 can cross the blood-brain barrier (BBB). ED11 has the potential for the study of Huntington's disease (HD) .
loading...
    loading...
Cat. No.: HY-W635511
CAS No.: 1438463-77-4
Target:  

Caspase

Research Areas:  

Neurological Disease

Caspase-6-IN-1 is a Caspase-6 inhibitor with an IC50 of 5.6 μM. Caspase-6-IN-1 can inhibit Caspase-6 activity and reduce lamin A hydrolysis. Caspase-6-IN-1 can be used for the research of neurodegenerative diseases such as Huntington's disease and Alzheimer's disease .
loading...
    loading...
Cat. No.: HY-P4401A
Target:  

Fluorescent Dye Caspase

Research Areas:  

Others

Z-VEID-AFC TFA is the trifluoroacetate salt of Z-VEID-AFC (HY-P4401). Z-VEID-AFC TFA is a fluorescent substrate for caspase-6. When Z-VEID-AFC TFA is cleaved by caspase-6, 7-amino-4-trifluoromethylcoumarin (AFC) is released, and its fluorescence can be used to quantify caspase-6 activity (Ex/Em: 400/505 nm) .
loading...
    loading...
Cat. No.: HY-P4401
CAS No.: 219138-06-4
Target:  

Caspase

Research Areas:  

Others

Z-VEID-AFC is a fluorescent substrate for caspase-6 .
loading...
    loading...
Cat. No.: HY-P81812
Synonyms: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Rat

loading...
    loading...
Cat. No.: HY-P86135
Synonyms: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P81812A
Synonyms: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Rat

loading...
    loading...
Cat. No.: HY-P80048

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P84403
Synonyms: MCH2

Host:  

Mouse

Application:  

ICC/IF, FC, ELISA

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P84403A
Synonyms: MCH2

Host:  

Mouse

Application:  

ICC/IF, FC, ELISA

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P80047
Synonyms: MCH2, CASP6, Caspase-6, CASP-6, CSP-6, Apoptotic protease Mch-2

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, IP

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-RS01959
Research Areas:  

Others

CASP6 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...