Caspase-6

Isoforms Recommended:	Caspase 6

By Targets:	Caspase (16) Akt (2) Apoptosis (5) Autophagy (2) Bcl-2 Family (1) DNA/RNA Synthesis (1) Ferroptosis (2) Fluorescent Dye (2) FOXO (1) Fungal (2) GSK-3 (1) IRE1 (2) JNK (2) KMO (1) Microtubule/Tubulin (1) mTOR (2) Reactive Oxygen Species (ROS) (2) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (1) YAP (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Neurological Disease (6)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1007

Z-VEID-FMK Z-VE(OMe)ID(OMe)-FMK	Caspase Apoptosis	Cancer
Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible *caspase-6* peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .

HY-137038

N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride TLCK hydrochloride	Caspase Ser/Thr Protease FOXO	Cardiovascular Disease Cancer
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC₅₀ of 12.0 μM against *Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1*. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of *caspase-6* and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-108312A

Ac-VEID-CHO TFA	Caspase	Neurological Disease
Ac-VEID-CHO (TFA) is a peptide-derived *caspase* inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. Ac-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .

HY-P5983

Ac-VEID-AFC 1 Publications Verification	Caspase	Cancer
Ac-VEID-AFC is a *caspase-6* fluorogenic substrate, and can be used in the caspase 6 activity assay .

HY-N3000

6-Methoxydihydrosanguinarine	JNK IRE1 Akt mTOR YAP Reactive Oxygen Species (ROS) Autophagy Apoptosis Ferroptosis Fungal	Infection Inflammation/Immunology Cancer
6-Methoxydihydrosanguinarine is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and *caspases*. 6-Methoxydihydrosanguinarine induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine disruptes the biofilm formation of Candida albicans (C. albicans). 6-Methoxydihydrosanguinarine can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer ^[6] .

HY-125194

NWL-117	Caspase	Neurological Disease
NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC₅₀ value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease .

HY-108312

Ac-VEID-CHO	Caspase	Neurological Disease
Ac-VEID-CHO is a peptide-derived *caspase* inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. Ac-VEID-CHO also inhibits VEIDase activity an IC₅₀ value of 0.49 µM. Ac-VEID-CHO can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .

HY-P10822

ED11	Caspase	Neurological Disease
ED11 is a potent and selective *caspase-6* inhibitor with an IC₅₀ of 12.12 nM. ED11 competes with Htt for the caspase-6 active site, and thus reduce Htt cleavage. ED11 can cross the blood-brain barrier (BBB). ED11 has the potential for the study of Huntington's disease (HD) .

HY-W635511

Caspase-6-IN-1	Caspase	Neurological Disease
Caspase-6-IN-1 is a *Caspase-6* inhibitor with an IC₅₀ of 5.6 μM. Caspase-6-IN-1 can inhibit Caspase-6 activity and reduce lamin A hydrolysis. Caspase-6-IN-1 can be used for the research of neurodegenerative diseases such as Huntington's disease and Alzheimer's disease .

HY-P4401A

Z-VEID-AFC TFA	Fluorescent Dye Caspase	Others
Z-VEID-AFC TFA is the trifluoroacetate salt of Z-VEID-AFC (HY-P4401). Z-VEID-AFC TFA is a fluorescent substrate for caspase-6. When Z-VEID-AFC TFA is cleaved by caspase-6, 7-amino-4-trifluoromethylcoumarin (AFC) is released, and its fluorescence can be used to quantify caspase-6 activity (Ex/Em: 400/505 nm) .

HY-P4401

Z-VEID-AFC	Caspase	Others
Z-VEID-AFC is a fluorescent substrate for caspase-6 .

HY-RS01959

CASP6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Caspase	Others
CASP6 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CASP6 Human Pre-designed siRNA Set A CASP6 Human Pre-designed siRNA Set A

HY-181988

DTB-acid	Caspase KMO GSK-3	Neurological Disease
DTB-acid is a multi-target inhibitor that binds stably to *Caspase-6, KMO* and GSK-3β. DTB-acid is applicable to the research of Huntington's disease .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for *caspase 6*, that cleaves the lamin A at the cleavage site of VEID .

HY-136893

SP-6-27	Microtubule/Tubulin Apoptosis Caspase Bcl-2 Family	Cancer
SP-6-27 is a tubulin depolymerizing agent that binds to the colchicine site of β-tubulin. SP-6-27 induces G₂/M cell cycle arrest in ovarian cancer cells. SP-6-27 enhances intrinsic apoptosis in ovarian cancer cells through upregulation of Bax, Apaf-1, *caspase-6, caspase-9, and caspase-3*. SP-6-27 reduces ovarian cancer cell migration. SP-6-27 inhibits capillary tube formation by human umbilical vein endothelial cells. SP-6-27 shows minimum cytotoxicity to normal ovarian epithelia. SP-6-27 shows enhanced cytotoxicity in chemo-sensitive/resistant ovarian cancer cells when combined with Cisplatin (HY-17394). SP-6-27 can be used for the research of ovarian cancer .

HY-P11865

Ac-ATS010-KE	Caspase Apoptosis	Cancer
Ac-ATS010-KE is a selective polypeptide inhibitor of *caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase*-3-targeted molecular probes .

HY-N3000A

6-Methoxydihydrosanguinarine hydrochloride	JNK IRE1 Akt mTOR YAP Reactive Oxygen Species (ROS) Autophagy Apoptosis Ferroptosis Fungal Caspase DNA/RNA Synthesis	Infection Inflammation/Immunology Cancer
6-Methoxydihydrosanguinarine hydrochloride is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine hydrochloride activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and *caspases*. 6-Methoxydihydrosanguinarine hydrochloride induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine hydrochloride disruptes the biofilm formation of Candida albicans (C. albicans). 6-Methoxydihydrosanguinarine hydrochloride can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer ^[6] .

Cat. No.	Product Name	Type

HY-P2065

Ac-VEID-AMC	Fluorescent Dyes
Ac-VEID-AMC is a fluorescent substrate for the determination of *caspase-6* and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P1007

Z-VEID-FMK Z-VE(OMe)ID(OMe)-FMK	Caspase Apoptosis	Cancer
Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible *caspase-6* peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of *caspase-6* and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-108312A

Ac-VEID-CHO TFA	Caspase	Neurological Disease
Ac-VEID-CHO (TFA) is a peptide-derived *caspase* inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. Ac-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .

HY-P5983

Ac-VEID-AFC 1 Publications Verification	Caspase	Cancer
Ac-VEID-AFC is a *caspase-6* fluorogenic substrate, and can be used in the caspase 6 activity assay .

HY-P10822

ED11	Caspase	Neurological Disease
ED11 is a potent and selective *caspase-6* inhibitor with an IC₅₀ of 12.12 nM. ED11 competes with Htt for the caspase-6 active site, and thus reduce Htt cleavage. ED11 can cross the blood-brain barrier (BBB). ED11 has the potential for the study of Huntington's disease (HD) .

HY-P4401A

Z-VEID-AFC TFA	Fluorescent Dye Caspase	Others
Z-VEID-AFC TFA is the trifluoroacetate salt of Z-VEID-AFC (HY-P4401). Z-VEID-AFC TFA is a fluorescent substrate for caspase-6. When Z-VEID-AFC TFA is cleaved by caspase-6, 7-amino-4-trifluoromethylcoumarin (AFC) is released, and its fluorescence can be used to quantify caspase-6 activity (Ex/Em: 400/505 nm) .

HY-P4401

Z-VEID-AFC	Caspase	Others
Z-VEID-AFC is a fluorescent substrate for caspase-6 .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for *caspase 6*, that cleaves the lamin A at the cleavage site of VEID .

HY-P11865

Ac-ATS010-KE	Caspase Apoptosis	Cancer
Ac-ATS010-KE is a selective polypeptide inhibitor of *caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase*-3-targeted molecular probes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3000

6-Methoxydihydrosanguinarine	Alkaloids Structural Classification Classification of Application Fields Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Source Classification Cancer	JNK IRE1 Akt mTOR YAP Reactive Oxygen Species (ROS) Autophagy Apoptosis Ferroptosis Fungal
6-Methoxydihydrosanguinarine is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and *caspases*. 6-Methoxydihydrosanguinarine induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine disruptes the biofilm formation of Candida albicans (C. albicans). 6-Methoxydihydrosanguinarine can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer ^[6] .

HY-N3000A

6-Methoxydihydrosanguinarine hydrochloride	Structural Classification Alkaloids Meconopsis simplicifolia (D. Don) Walp. Quinoline Alkaloids Plants Papaveraceae Source Classification	JNK IRE1 Akt mTOR YAP Reactive Oxygen Species (ROS) Autophagy Apoptosis Ferroptosis Fungal Caspase DNA/RNA Synthesis
6-Methoxydihydrosanguinarine hydrochloride is an alkaloid with activity across multiple cancer cell types. 6-Methoxydihydrosanguinarine hydrochloride activates IRE1/JNK signaling, blocks Akt/mTOR and PI3K/AKT/mTOR pathways, reduces expression of Cdc25C, CyclinB1, Cdc2, YAP/TAZ, Survivin, GPX4, and EGFR, upregulates IRE1 and DR5, and activates JNK and *caspases*. 6-Methoxydihydrosanguinarine hydrochloride induces apoptosis, G2/M phase arrest, DNA damage, ROS generation, lipid peroxidation, ferroptosis, autophagy, and suppresses cancer cell growth. 6-Methoxydihydrosanguinarine hydrochloride disruptes the biofilm formation of Candida albicans (C. albicans). 6-Methoxydihydrosanguinarine hydrochloride can be used for the research of non-small cell lung cancer, hepatocellular carcinoma, melanoma, colon carcinoma, ovarian cancer and breast cancer ^[6] .

Host:	Mouse (2) Rabbit (5)
Reactivity:	Human (7) Mouse (2) Rat (4)
Application:	IHC-P (2) ICC/IF (4) IP (2) WB (5) FC (2) ELISA (3)
Isotype:	IgG (5) IgG2a (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (5) Recombinant (3)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81812

	Caspase-6 Antibody (YA1557) CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2	WB	Human, Rat
	Caspase-6 Antibody (YA1557) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-6.

HY-P86135

	Caspase-6 Antibody (YA5827) CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Caspase-6 Antibody (YA5827) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-6.

HY-P81812A

	Caspase-6 Antibody (YA1557)(PBS only) CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2	WB	Human, Rat
	Caspase-6 Antibody (YA1557) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-6.

HY-P80047

	Caspase-6 Antibody (YA556)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	Caspase-6 Antibody (YA556) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-6.

HY-P80048

	Caspase-6 p18 Antibody (YA555)	WB	Human
	Caspase-6 p18 Antibody (YA555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-6 p18.

HY-P84403

	Caspase-6 Antibody (YA4100) MCH2	ICC/IF, FC, ELISA	Human
	Caspase-6 Antibody (YA4100) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Caspase-6.

HY-P84403A

	Caspase-6 Antibody (YA4100)(PBS only) MCH2	ICC/IF, FC, ELISA	Human
	Caspase-6 Antibody (YA4100) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Caspase-6.

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Cat. No.	Product Name		Classification

HY-RS01959

CASP6 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CASP6 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Caspase-6

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