2. Apoptosis
  3. Caspase Apoptosis
  4. Ac-ATS010-KE

Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-ATS010-KE

Ac-ATS010-KE Chemical Structure

CAS No. : 2379342-67-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Ac-ATS010-KE Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes[1].

IC50 & Target[1]

Caspase-3

 

In Vitro

Ac-ATS010-KE potently inhibits purified recombinant caspase-3 and exhibits high selectivity over caspase-6, caspase-7, caspase-8, caspase-9, and caspase-10[1].
Ac-ATS010-KE protects Jurkat cells from MegaFasL-induced apoptosis, with non-methylated Ac-ATS010-KE showing superior performance compared to its per-methylated counterpart[1].
Ac-ATS010-KE (25 µM; 1 hour) reduces [18F]MICA-316 uptake in STS-treated caspase-3-positive HeLa cells, demonstrating competitive binding to caspase-3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-ATS010-KE Related Antibodies
In Vivo

Ac-ATS010-KE-derived radiotracer [18F]MICA-316 (~18.5 MBq; intravenous injection) binds to activated caspase-3 in tumor homogenates in vitro, and exhibits low and non-differential tumor uptake[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1-/- nude (female, 6-8 weeks old, 20-25 g, subcutaneous colorectal cancer xenograft model)[1]
Dosage: 18.5 MBq
Administration: i.v.
Result: Showed tumour uptake of 0.55 %ID/CC at 60 minutes post-injection in conatumumab-treated mice and 0.52 %ID/CC in IgG1 isotype control-treated mice.
Demonstrated no significant difference in high-intensity voxel (P95) intensity between treated and control groups.
Bound active caspase-3 (17 and 19 kDa subunits) in homogenates of conatumumab (HY-P99260)-treated COLO205 tumours.
Animal Model: CD1-/- nude (female, 6-8 weeks old, 20-25 g)[1]
Dosage: 18.5 MBq
Administration: i.v.
Result: Exhibited rapid blood clearance, mixed renal-hepatobiliary excretion, negligible bone uptake, and low non-specific background uptake.
Showed low in vivo serum stability, with < 30% intact tracer remaining for [18F]MICA-314 to -318 at 30 minutes post-injection; [18F]MICA-320 had 58.8% intact tracer remaining at 30 minutes.
Molecular Weight

960.88

Formula

C43H41F5N6O12S
CAS No.
Sequence

Ac-Pal-Asp-{Phe(F5)}-Phe-Asp-KE
Sequence Shortening

Ac-{Pal}-D-{Phe(F5)}-FD-KE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Ac-ATS010-KE Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-ATS010-KE2379342-67-1CaspaseApoptosisJurkat cellscaspase-9caspase-6colorectal cancercaspase-10caspase-3caspase-8caspase-7HeLa cellsapoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ac-ATS010-KE
Cat. No.:
HY-P11865
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.