Ac-ATS010-KE 

Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes^[1].

Ac-ATS010-KE potently inhibits purified recombinant caspase-3 and exhibits high selectivity over caspase-6, caspase-7, caspase-8, caspase-9, and caspase-10^[1].
Ac-ATS010-KE protects Jurkat cells from MegaFasL-induced apoptosis, with non-methylated Ac-ATS010-KE showing superior performance compared to its per-methylated counterpart^[1].
Ac-ATS010-KE (25 µM; 1 hour) reduces [¹⁸F]MICA-316 uptake in STS-treated caspase-3-positive HeLa cells, demonstrating competitive binding to caspase-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-ATS010-KE-derived radiotracer [¹⁸F]MICA-316 (~18.5 MBq; intravenous injection) binds to activated caspase-3 in tumor homogenates in vitro, and exhibits low and non-differential tumor uptake^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

960.88

C₄₃H₄₁F₅N₆O₁₂S

2379342-67-1

Ac-Pal-Asp-{Phe(F5)}-Phe-Asp-KE

Ac-{Pal}-D-{Phe(F5)}-FD-KE

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lauwerys L, et al. Development of caspase-3-selective activity-based probes for PET imaging of apoptosis. EJNMMI Radiopharm Chem. 2024 Aug;9:58.