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Cat. No.: HY-P11865

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Ac-ATS010-KE

Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2379342-67-1
Formule: C₄₃H₄₁F₅N₆O₁₂S
Masse moléculaire:960.88

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Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

Ac-ATS010-KE Chemical Structure

CAS No.: 2379342-67-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

Caspase-3

Voir tous les produits spécifiques à Isoform Caspase :

In Vitro

Ac-ATS010-KE potently inhibits purified recombinant caspase-3 and exhibits high selectivity over caspase-6, caspase-7, caspase-8, caspase-9, and caspase-10^[1].
Ac-ATS010-KE protects Jurkat cells from MegaFasL-induced apoptosis, with non-methylated Ac-ATS010-KE showing superior performance compared to its per-methylated counterpart^[1].
Ac-ATS010-KE (25 µM; 1 hour) reduces [¹⁸F]MICA-316 uptake in STS-treated caspase-3-positive HeLa cells, demonstrating competitive binding to caspase-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ac-ATS010-KE-derived radiotracer [¹⁸F]MICA-316 (~18.5 MBq; intravenous injection) binds to activated caspase-3 in tumor homogenates in vitro, and exhibits low and non-differential tumor uptake^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2379342-67-1
Masse moléculaire 960.88
Formule C₄₃H₄₁F₅N₆O₁₂S
Sequence

Ac-Pal-Asp-{Phe(F5)}-Phe-Asp-KE
Sequence Shortening

Ac-{Pal}-D-{Phe(F5)}-FD-KE
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lauwerys L, et al. Development of caspase-3-selective activity-based probes for PET imaging of apoptosis. EJNMMI Radiopharm Chem. 2024 Aug;9:58.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Ac-ATS010-KE

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Ac-ATS010-KE Related Classifications

HY-P11865 Related Classifications