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Results for "

Chymase

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

7

Peptides

2

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109059
    Fulacimstat
    2 Publications Verification

    BAY1142524

    		 Proteasome Cardiovascular Disease
    Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively.
    Fulacimstat
  • HY-P4159
    Endothelin-1 (1-31) (Human)
    1 Publications Verification

    		 ERK Cardiovascular Disease
    Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .
    Endothelin-1 (1-31) (Human)
  • HY-P4159A
    Endothelin-1 (1-31) (Human) TFA
    1 Publications Verification

    		 ERK Cardiovascular Disease
    Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .
    Endothelin-1 (1-31) (Human) TFA
  • HY-P4476
    Suc-AAPA-pNA
    1 Publications Verification

    		 Ser/Thr Protease Others
    Suc-AAPA-pNA is a substrate for chymotrypsin A and elastase. Suc-AAPA-pNA can be used for enzyme activity assay .
    Suc-AAPA-pNA
  • HY-12370
    TY-51469
    1 Publications Verification

    		 Proteasome Inflammation/Immunology
    TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
    TY-51469
  • HY-P2922
    Cathepsin C

    		Cathepsin Cancer
    Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .
    Cathepsin C
  • HY-122161
    JNJ-10311795

    RWJ-355871

    		 Cathepsin Inflammation/Immunology
    JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity .
    JNJ-10311795
  • HY-100269
    Chymase-IN-1

    		Proteasome Inflammation/Immunology
    Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
    Chymase-IN-1
  • HY-131162
    Chymase

    		Angiotensin Receptor Cardiovascular Disease
    Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies .
    Chymase
  • HY-P4159B
    Endothelin-1 (1-31) (Human) acetate

    		ERK Cardiovascular Disease
    Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .
    Endothelin-1 (1-31) (Human) acetate
  • HY-U00282
    Chymase-IN-2

    		Proteasome Inflammation/Immunology
    Chymase-IN-2 is a chymase modulator which is useful in the treatment of inflammatory and serine protease mediated disorders.
    Chymase-IN-2
  • HY-16707
    CH 5450

    Z-Ile-Glu-Pro-Phe-Ome

    		 Proteasome Inflammation/Immunology
    CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 µM .
    CH 5450
  • HY-P1347
    RETF-4NA

    		Biochemical Assay Reagents Metabolic Disease
    RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M .
    RETF-4NA
  • HY-168904
    BI-1942

    		Proteasome Others
    BI-1942, a chemical probe, is a chymase inhibitor and has an IC50 of 0.4 nM for human chymase. BI-1942 can be used in the research of ophthalmic diseases .
    BI-1942
  • HY-12514
    NK3201

    		Ser/Thr Protease
    NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein .
    NK3201
  • HY-RS02853
    CMA1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CMA1 Human Pre-designed siRNA Set A contains three designed siRNAs for CMA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CMA1 Human Pre-designed siRNA Set A
    CMA1 Human Pre-designed siRNA Set A
  • HY-126988
    SP-Chymostatin B

    α-MAPI

    		 Elastase Others
    SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .
    SP-Chymostatin B
  • HY-Y0370
    6-Chlorooxindole

    		Proteasome Cardiovascular Disease
    6-Chlorooxindole (compound 2) is a selective chymase inhibitor with an IC50 of 470 μM. 6-Chlorooxindole shows >100-fold selectivity for chymase over cathepsin G. 6-Chlorooxindole can be used for the study of cardiovascular disease .
    6-Chlorooxindole
  • HY-105360
    GI-129471

    		MMP Inflammation/Immunology Cancer
    GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I). GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes .
    GI-129471
  • HY-180131
    INVA8001

    ASB17061

    		 Proteasome Inflammation/Immunology
    INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects .
    INVA8001

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